Search Results - "Dryden, Gerald W"

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway by Singh, Rajbir, Chandrashekharappa, Sandeep, Bodduluri, Sobha R., Baby, Becca V., Hegde, Bindu, Kotla, Niranjan G., Hiwale, Ankita A., Saiyed, Taslimarif, Patel, Paresh, Vijay-Kumar, Matam, Langille, Morgan G. I., Douglas, Gavin M., Cheng, Xi, Rouchka, Eric C., Waigel, Sabine J., Dryden, Gerald W., Alatassi, Houda, Zhang, Huang-Ge, Haribabu, Bodduluri, Vemula, Praveen K., Jala, Venkatakrishna R.

“…The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of…”
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High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance by Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Dryden, Gerald W., Sriwastva, Mukesh K., Lei, Chao, Zhang, Lifeng, Qiu, Xiaolan, Xu, Fangyi, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L., Bohler, Henry C. L., Wang, Baomei, Zhang, Shuangqin, Qin, Chao, Xu, Ziying, Han, Xianlin, McClain, Craig J., Teng, Yun, Zhang, Huang-Ge

“…High-fat diet (HFD) decreases insulin sensitivity. How high-fat diet causes insulin resistance is largely unknown. Here, we show that lean mice become insulin…”
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Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease by Somineni, Hari K., Nagpal, Sini, Venkateswaran, Suresh, Cutler, David J., Okou, David T., Haritunians, Talin, Simpson, Claire L., Begum, Ferdouse, Datta, Lisa W., Quiros, Antonio J., Seminerio, Jenifer, Mengesha, Emebet, Alexander, Jonathan S., Baldassano, Robert N., Dudley-Brown, Sharon, Cross, Raymond K., Dassopoulos, Themistocles, Denson, Lee A., Dhere, Tanvi A., Iskandar, Heba, Dryden, Gerald W., Hou, Jason K., Hussain, Sunny Z., Hyams, Jeffrey S., Isaacs, Kim L., Kader, Howard, Kappelman, Michael D., Katz, Jeffry, Kellermayer, Richard, Kuemmerle, John F., Lazarev, Mark, Li, Ellen, Mannon, Peter, Moulton, Dedrick E., Newberry, Rodney D., Patel, Ashish S., Pekow, Joel, Saeed, Shehzad A., Valentine, John F., Wang, Ming-Hsi, McCauley, Jacob L., Abreu, Maria T., Jester, Traci, Molle-Rios, Zarela, Palle, Sirish, Scherl, Ellen J., Kwon, John, Rioux, John D., Duerr, Richard H., Silverberg, Mark S., Zwick, Michael E., Stevens, Christine, Daly, Mark J., Cho, Judy H., Gibson, Greg, McGovern, Dermot P.B., Brant, Steven R., Kugathasan, Subra

“…Whether or not populations diverge with respect to the genetic contribution to risk of specific complex diseases is relevant to understanding the evolution of…”
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Development and validation of a product acceptability questionnaire for intranasal Q-Griffithsin COVID-19 prophylaxis (SPRAY PAL) by Cash, Elizabeth, Deitz, Kailyn, Potts, Kevin L, Nabeta, Henry W, Zahin, Maryam, Rai, Shesh N, Dryden, Gerald W, Palmer, Kenneth E

“…Objectives Patient experiences are critical when determining the acceptability of novel interventional pharmaceuticals. Here, we report the development and…”
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An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth by Sriwastva, Mukesh K., Teng, Yun, Mu, Jingyao, Xu, Fangyi, Kumar, Anil, Sundaram, Kumaran, Malhotra, Rajiv Kumar, Xu, Qingbo, Hood, Joshua L., Zhang, Lifeng, Yan, Jun, Merchant, Michael L., Park, Juw Won, Dryden, Gerald W., Egilmez, Nejat K., Zhang, Huang‐Ge

“…Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or…”
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Relationship between gut microbiota and development of T cell associated disease by Kosiewicz, Michele M., Dryden, Gerald W., Chhabra, Anita, Alard, Pascale

“…The interplay between the immune response and the gut microbiota is complex. Although it is well-established that the gut microbiota is essential for the…”
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Clinical implications of oxidative stress and antioxidant therapy by Dryden, Jr, Gerald W, Deaciuc, Ion, Arteel, Gavin, McClain, Craig J

“…Oxidative stress occurs when there is an imbalance between generation of reactive oxygen species and inadequate antioxidant defense systems. Oxidative stress…”
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Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway by Sriwastva, Mukesh K, Deng, Zhong‐Bin, Wang, Bomei, Teng, Yun, Kumar, Anil, Sundaram, Kumaran, Mu, Jingyao, Lei, Chao, Dryden, Gerald W, Xu, Fangyi, Zhang, Lifeng, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Egilmez, Nejat K, Zhang, Huang‐Ge

“…Bark protects the tree against environmental insults. Here, we analyzed whether this defensive strategy could be utilized to broadly enhance protection against…”
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Overview of biologic therapy for Crohn's disease by Dryden, Jr, Gerald W

“…Therapy for Crohn's disease (CD) is evolving at breakneck speed. Biologic therapies are assuming ever more important roles in treating this unrelenting,…”
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Gut Immunology and the Differential Response to Feeding and Starvation by Jabbar, Abdul, Chang, Wei-Kuo, Dryden, Gerald W., McClave, Stephen A.

“…Animal and human research has established the beneficial effects of enteral nutrition on the gut. Both the innate and acquired immune systems are bolstered by…”
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Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis by Sundaram, Kumaran, Mu, Jingyao, Kumar, Anil, Behera, Jyotirmaya, Lei, Chao, Sriwastva, Mukesh K, Xu, Fangyi, Dryden, Gerald W, Zhang, Lifeng, Chen, ShaoYu, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Tyagi, Neetu, Teng, Yun, Zhang, Huang-Ge

“…Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced…”
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A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis by Dryden, Gerald W, Lam, Allan, Beatty, Karen, Qazzaz, Hassan H, McClain, Craig J

“…Green tea and its main polyphenolic component, (-)-epigallocatechin-3-gallate (EGCG), exert powerful anti-inflammatory effects that are protective against both…”
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miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase ( tnaA ) gene by Kumar, Anil, Ren, Yi, Sundaram, Kumaran, Mu, Jingyao, Sriwastva, Mukesh K, Dryden, Gerald W, Lei, Chao, Zhang, Lifeng, Yan, Jun, Zhang, Xiang, Park, Juw Won, Merchant, Michael L, Teng, Yun, Zhang, Huang-Ge

“…Diet manipulation is the basis for prevention of obesity and diabetes. The molecular mechanisms that mediate the diet-based prevention of insulin resistance…”
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Outer Membrane Vesicles Released from Garlic Exosome‐like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut‐Brain Axis by Sundaram, Kumaran, Teng, Yun, Mu, Jingyao, Xu, Qingbo, Xu, Fangyi, Sriwastva, Mukesh K., Zhang, Lifeng, Park, Juw Won, Zhang, Xiang, Yan, Jun, Zhang, Shuang Qin, Merchant, Michael L., Chen, Shao‐yu, McClain, Craig J, Dryden, Gerald W, Zhang, Huang‐Ge

“…Gut microbiota function has numerous effects on humans and the diet humans consume has emerged as a pivotal determinant of gut microbiota function. Here, a new…”
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Comparison of Stromal Vascular Fraction with or Without a Novel Bioscaffold to Fibrin Glue in a Porcine Model of Mechanically Induced Anorectal Fistula by Dryden, Gerald W, Boland, Eugene, Yajnik, Vijay, Williams, Stuart

“…Anorectal fistulas (ARFs) are a common, devastating, event in the life of a patient with Crohn's disease. ARFs occur in up to 50% of patients with Crohn's…”
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Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease by Brant, Steven R, Okou, David T, Simpson, Claire L, Cutler, David J, Haritunians, Talin, Bradfield, Jonathan P, Chopra, Pankaj, Prince, Jarod, Begum, Ferdouse, Kumar, Archana, Huang, Chengrui, Venkateswaran, Suresh, Datta, Lisa W, Wei, Zhi, Thomas, Kelly, Herrinton, Lisa J, Klapproth, Jan-Micheal A, Quiros, Antonio J, Seminerio, Jenifer, Liu, Zhenqiu, Alexander, Jonathan S, Baldassano, Robert N, Dudley-Brown, Sharon, Cross, Raymond K, Dassopoulos, Themistocles, Denson, Lee A, Dhere, Tanvi A, Dryden, Gerald W, Hanson, John S, Hou, Jason K, Hussain, Sunny Z, Hyams, Jeffrey S, Isaacs, Kim L, Kader, Howard, Kappelman, Michael D, Katz, Jeffry, Kellermayer, Richard, Kirschner, Barbara S, Kuemmerle, John F, Kwon, John H, Lazarev, Mark, Li, Ellen, Mack, David, Mannon, Peter, Moulton, Dedrick E, Newberry, Rodney D, Osuntokun, Bankole O, Patel, Ashish S, Saeed, Shehzad A, Targan, Stephan R, Valentine, John F, Wang, Ming-Hsi, Zonca, Martin, Rioux, John D, Duerr, Richard H, Silverberg, Mark S, Cho, Judy H, Hakonarson, Hakon, Zwick, Michael E, McGovern, Dermot P.B, Kugathasan, Subra

“…Abstract Background & Aims The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD) cause significant morbidity and are…”
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Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis by Ghosh, Sweta, Singh, Rajbir, Goap, Tanu Jain, Sunnapu, Omprakash, Vanwinkle, Zachary M., Li, Hong, Nukavarapu, Syam P., Dryden, Gerald W., Haribabu, Bodduluri, Vemula, Praveen Kumar, Jala, Venkatakrishna Rao

“…Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies…”
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Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography by Bhutiani, Neal, Grizzle, William E, Galandiuk, Susan, Otali, Denis, Dryden, Gerald W, Egilmez, Nejat K, McNally, Lacey R

“…Currently, several noninvasive modalities, including MRI and PET, are being investigated to identify early intestinal inflammation, longitudinally monitor…”
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Fibroblast Growth Factor 21 Depletion Attenuates Acute Experimental Colitis In Mice Through Epithelial Stat3 Activation by Feng, Wenke, Dryden, Gerald W, McClain, Craig J

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Plasma microRNA Profile Differentiates Crohn's Colitis From Ulcerative Colitis by Netz, Uri, Carter, Jane, Eichenberger, M Robert, Feagins, Kayla, Galbraith, Norman J, Dryden, Gerald W, Pan, Jianmin, Rai, Shesh N, Galandiuk, Susan

“…Abstract Background Inflammatory bowel disease (IBD) is commonly divided into 2 entities: Crohn's disease (CD) and ulcerative colitis (UC). Differentiating…”
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