Search Results - "Drummond, Spencer"

An Unusual Trifluoromethyl Elimination Reaction from the 4,4-Bis(trifluoromethyl)-5-hydroxyimidazoline Ring System by Li, Hui-Yin, DeLucca, Indawati, Drummond, Spencer, Boswell, George A

“…A facile detrifluoromethylation was observed when 4,4-bis(trifluoromethyl)-5-hydroxyimidazoline 5 was treated with a variety of bases to afford the…”
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Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor by Pruitt, James R, Pinto, Donald J. P, Galemmo, Robert A, Alexander, Richard S, Rossi, Karen A, Wells, Brian L, Drummond, Spencer, Bostrom, Lori L, Burdick, Debra, Bruckner, Robert, Chen, Haiying, Smallwood, Angela, Wong, Pancras C, Wright, Matthew R, Bai, Steven, Luettgen, Joseph M, Knabb, Robert M, Lam, Patrick Y. S, Wexler, Ruth R

“…Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has…”
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Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues by Qiao, Jennifer X., Cheng, Xuhong, Smallheer, Joanne M., Galemmo, Robert A., Drummond, Spencer, Pinto, Donald J.P., Cheney, Daniel L., He, Kan, Wong, Pancras C., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.

“…The synthesis, SAR, pharmacokinetic profile, and modeling studies of both monocyclic and fused pyrazoles containing substituted N-arylpiperidinyl P4 moieties…”
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Steroidal nitrone inhibitors of 5α-reductase by Robinson, Andrea J, DeLucca, Indawati, Drummond, Spencer, Boswell, George A

“…This paper describes the rational design and synthesis of novel inhibitors of human steroid 5α-reductase. Steroidal nitrones were synthesised via an eight-step…”
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Singlet oxygen oxidation of pyrroles: Synthesis and chemical transformations of novel 4,4-bis(trifluoromethyl)imidazoline analogs by Li, Hui-Yin, Drummond, Spencer, DeLucca, Indawati, Boswell, George A.

“…Singlet oxygen or mCPBA oxidation of pyrrole 5b afforded a new series of 4,4-bis(trifluoromethyl)imidazolines with a para-substituted phenacyl side chain which…”
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Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1 by Pruitt, James R, Pinto, Donald J P, Galemmo, Jr, Robert A, Alexander, Richard S, Rossi, Karen A, Wells, Brian L, Drummond, Spencer, Bostrom, Lori L, Burdick, Debra, Bruckner, Robert, Chen, Haiying, Smallwood, Angela, Wong, Pancras C, Wright, Matthew R, Bai, Steven, Luettgen, Joseph M, Knabb, Robert M, Lam, Patrick Y S, Wexler, Ruth R

“…Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has…”
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Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl- N - [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1 H -pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor by Pruitt, James R., Pinto, Donald J. P., Galemmo, Robert A., Alexander, Richard S., Rossi, Karen A., Wells, Brian L., Drummond, Spencer, Bostrom, Lori L., Burdick, Debra, Bruckner, Robert, Chen, Haiying, Smallwood, Angela, Wong, Pancras C., Wright, Matthew R., Bai, Steven, Luettgen, Joseph M., Knabb, Robert M., Lam, Patrick Y. S., Wexler, Ruth R.

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Sequential Benzylic Oxidation of Naloxone 3-Methyl Ether by Cain, Gary A., Drummond, Spencer

“…Naloxone 3-methyl ether was selectively oxidized by treatment with cerium ammonium nitrate in aqueous acetonitrile at ambient temperature to provide the…”
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Novel piperidine .sigma. receptor ligands as potential antipsychotic drugs by Gilligan, Paul J, Cain, Gary A, Christos, Thomas E, Cook, Leonard, Drummond, Spencer, Johnson, Alexander L, Kergaye, Ahmed A, McElroy, John F, Rohrbach, Kenneth W

“…sigma receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel…”
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Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors by Li, Hui-Yin, DeLucca, Indawati, Drummond, Spencer, Boswell, George A.

“…An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and…”
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An Unusual Trifluoromethyl Elimination Reaction From the 4,4-Bis(trifluoromethyl)-5-hydroxyimidazoline Ring System by Li, Hui-Yin, DeLucca, Indawati, Drummond, Spencer, Broswell, George A

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Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents by Li, Hui-Yin, DeLucca, Indawati, Boswell, George A., Billheimer, Jeffrey T., Drummond, Spencer, Gillies, Peter J., Robinson, Candy

“…Novel 4,4-bis(trifluoromethyl)imidazolines have been found to be the potent acyl-CoA cholesterol acyltransferase (ACAT) inhibitors. ACAT is responsible for…”
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Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl coa: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents by Boswell, George A, Li, Hui-Yin, Delucca, Indawati, Billheimer, Jeffrey T., Drummond, Spencer, Gillies, Peter J., Robinson, Candy

“…A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Compound 6 and its…”
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South Africa by DRUMMOND, SPENCER

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Shelters And Car Parks by Spencer, Drummond

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Obedience To Orders by SPENCER-SMITH, DRUMMOND

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