Search Results - "Drummond, Bridgette E."

Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish by Drummond, Bridgette E, Ercanbrack, Wesley S, Wingert, Rebecca A

“…Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to…”
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Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development by Poureetezadi, Shahram Jevin, Cheng, Christina N, Chambers, Joseph M, Drummond, Bridgette E, Wingert, Rebecca A

“…Kidney formation involves patterning events that induce renal progenitors to form nephrons with an intricate composition of multiple segments. Here, we…”
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Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development by Wesselman, Hannah M, Nguyen, Thanh Khoa, Chambers, Joseph M, Drummond, Bridgette E, Wingert, Rebecca A

“…Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an…”
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osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2 by Drummond, Bridgette E., Chambers, Brooke E., Wesselman, Hannah M., Gibson, Shannon, Arceri, Liana, Ulrich, Marisa N., Gerlach, Gary F., Kroeger, Paul T., Leshchiner, Ignaty, Goessling, Wolfram, Wingert, Rebecca A.

“…Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the…”
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Insights into kidney stem cell development and regeneration using zebrafish by Drummond, Bridgette E, Wingert, Rebecca A

“…Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research…”
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Evolving technology: creating kidney organoids from stem cells by Chambers, Joseph M., McKee, Robert A., Drummond, Bridgette E., Wingert, Rebecca A.

“…The kidney is a complex organ whose excretory and regulatory functions are vital for maintaining homeostasis. Previous techniques used to study the kidney,…”
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Prostaglandin signaling regulates renal multiciliated cell specification and maturation by Marra, Amanda N., Adeeb, Basma D., Chambers, Brooke E., Drummond, Bridgette E., Ulrich, Marisa, Addiego, Amanda, Springer, Meghan, Poureetezadi, Shahram J., Chambers, Joseph M., Ronshaugen, Matthew, Wingert, Rebecca A.

“…Multiciliated cells (MCCs) are specialized epithelia with apical bundles of motile cilia that direct fluid flow. MCC dysfunction is associated with human…”
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The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish by Drummond, Bridgette E., Li, Yue, Marra, Amanda N., Cheng, Christina N., Wingert, Rebecca A.

“…The simplified and genetically conserved zebrafish pronephros is an excellent model to examine the cryptic processes of cell fate decisions during the…”
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A pan-cancer organoid platform for precision medicine by Larsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing, Khullar, Gaurav, Krantz, Benjamin A., Mapes, Brandon, McKinnon, Kelly E., Metti, Jessica, Perera, Jason F., Rand, Tim A., Sanchez-Freire, Veronica, Shaxted, Jenna M., Stein, Michelle M., Streit, Michael A., Tan, Yi-Hung Carol, Zhang, Yilin, Zhao, Ende, Venkataraman, Jagadish, Stumpe, Martin C., Borgia, Jeffrey A., Masood, Ashiq, Catenacci, Daniel V.T., Mathews, Jeremy V., Gursel, Demirkan B., Wei, Jian-Jun, Welling, Theodore H., Simeone, Diane M., White, Kevin P., Khan, Aly A., Igartua, Catherine, Salahudeen, Ameen A.

“…Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However,…”
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Homeogene emx1 is required for nephron distal segment development in zebrafish by Morales, Elvin E., Handa, Nicole, Drummond, Bridgette E., Chambers, Joseph M., Marra, Amanda N., Addiego, Amanda, Wingert, Rebecca A.

“…Vertebrate kidneys contain nephron functional units where specialized epithelial cell types are organized into segments with discrete physiological roles. Many…”
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The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development by Kroeger, Paul T., Drummond, Bridgette E., Miceli, Rachel, McKernan, Michael, Gerlach, Gary F., Marra, Amanda N., Fox, Annemarie, McCampbell, Kristen K., Leshchiner, Ignaty, Rodriguez-Mari, Adriana, BreMiller, Ruth, Thummel, Ryan, Davidson, Alan J., Postlethwait, John, Goessling, Wolfram, Wingert, Rebecca A.

“…The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste…”
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Unique pattern of molt leads to low intraindividual variation in feather mercury concentrations in penguins by Brasso, Rebecka L., Drummond, Bridgette E., Borrett, Stuart R., Chiaradia, André, Polito, Michael J., Rey, Andrea Raya

“…The authors hypothesized that the catastrophic annual molt of penguins (Sphenisciformes) would lead to reduced intraindividual variation of mercury…”
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Visualizing gene expression during zebrafish pronephros development and regeneration by Marra, Amanda N, Chambers, Brooke E, Chambers, Joseph M, Drummond, Bridgette E, Adeeb, Basma D, Wesselman, Hannah M, Morales, Elvin E, Handa, Nicole, Pettini, Tom, Ronshaugen, Matthew, Wingert, Rebecca A

“…The vertebrate kidney is comprised of functional units known as nephrons. Defects in nephron development or activity are a common feature of kidney disease…”
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Scaling up to Study Kidney Development: Using the Zebrafish as a Highthroughput Model to Identify Novel Genetic Regulators by Drummond, Bridgette E

“…Chronic kidney disease (CKD), though not reported on much in the media, is a disease that kills more Americans every year than breast or prostate cancer…”
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Iosr1/I Maintains Renal Progenitors and Regulates Podocyte Development by Promoting Iwnt2ba/I via the Antagonism of Ihand2/I by Drummond, Bridgette E, Chambers, Brooke E, Wesselman, Hannah M, Gibson, Shannon, Arceri, Liana, Ulrich, Marisa N, Gerlach, Gary F, Kroeger, Paul T, Leshchiner, Ignaty, Goessling, Wolfram, Wingert, Rebecca A

“…Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the…”
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