Search Results - "Druillennec, Sabine"

Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma by Cerezo, Michaël, Guemiri, Ramdane, Druillennec, Sabine, Girault, Isabelle, Malka-Mahieu, Hélène, Shen, Shensi, Allard, Delphine, Martineau, Sylvain, Welsch, Caroline, Agoussi, Sandrine, Estrada, Charlène, Adam, Julien, Libenciuc, Cristina, Routier, Emilie, Roy, Séverine, Désaubry, Laurent, Eggermont, Alexander M., Sonenberg, Nahum, Scoazec, Jean Yves, Eychène, Alain, Vagner, Stéphan, Robert, Caroline

“…Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and…”
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RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma by Dorard, Coralie, Estrada, Charlène, Barbotin, Céline, Larcher, Magalie, Garancher, Alexandra, Leloup, Jessy, Beermann, Friedrich, Baccarini, Manuela, Pouponnot, Celio, Larue, Lionel, Eychène, Alain, Druillennec, Sabine

“…NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers,…”
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Interplay Between Diabetes and Pancreatic Ductal Adenocarcinoma and Insulinoma: The Role of Aging, Genetic Factors, and Obesity by Duvillié, Bertrand, Kourdoughli, Rayane, Druillennec, Sabine, Eychène, Alain, Pouponnot, Celio

“…Epidemiologic analyses have shed light on an association between type 2 diabetes (T2D) and pancreatic ductal adenocarcinoma (PDAC). Recent data also suggest a…”
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Epigenetic upregulation of Schlafen11 renders 
WNT- and SHH-activated medulloblastomas sensitive to cisplatin by Nakata, Satoshi, Murai, Junko, Okada, Masayasu, Takahashi, Haruhiko, Findlay, Tyler H, Malebranche, Kristen, Parthasarathy, Akhila, Miyashita, Satoshi, Gabdulkhaev, Ramil, Benkimoun, Ilan, Druillennec, Sabine, Chabi, Sara, Hawkins, Eleanor, Miyahara, Hiroaki, Tateishi, Kensuke, Yamashita, Shinji, Yamada, Shiori, Saito, Taiki, On, Jotaro, Watanabe, Jun, Tsukamoto, Yoshihiro, Yoshimura, Junichi, Oishi, Makoto, Nakano, Toshimichi, Imamura, Masaru, Imai, Chihaya, Yamamoto, Tetsuya, Takeshima, Hideo, Sasaki, Atsuo T, Rodriguez, Fausto J, Nobusawa, Sumihito, Varlet, Pascale, Pouponnot, Celio, Osuka, Satoru, Pommier, Yves, Kakita, Akiyoshi, Fujii, Yukihiko, Raabe, Eric H, Eberhart, Charles G, Natsumeda, Manabu

“…Abstract Background Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However,…”
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Skin Tumors Induced by Sorafenib; Paradoxic RAS―RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1 by ARNAULT, Jean Philippe, MATEUS, Christine, ANDRE, Jocelyne, KAMSU-KOM, Nyam, BOUSSEMART, Lise, LACROIX, Ludovic, SPATZ, Alain, EGGERMONT, Alexander M, DRUILLENNEC, Sabine, VAGNER, Stephan, EYCHENE, Alain, DUMAZ, Nicolas, ESCUDIER, Bernard, ROBERT, Caroline, TOMASIC, Gorana, WECHSLER, Janine, HOLLVILLE, Emilie, SORIA, Jean-Charles, MALKA, David, SARASIN, Alain, LARCHER, Magalie

“…The emergence of skin tumors in patients treated with sorafenib or with more recent BRAF inhibitors is an intriguing and potentially serious event. We carried…”
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Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation by Coste, Isabelle, Le Corf, Katy, Kfoury, Alain, Hmitou, Isabelle, Druillennec, Sabine, Hainaut, Pierre, Eychene, Alain, Lebecque, Serge, Renno, Toufic

“…Accumulating evidence points to inflammation as a promoter of carcinogenesis. MyD88 is an adaptor molecule in TLR and IL-1R signaling that was recently…”
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MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells by Estrada, Charlène, Mirabal-Ortega, Liliana, Méry, Laurence, Dingli, Florent, Besse, Laetitia, Messaoudi, Cedric, Loew, Damarys, Pouponnot, Celio, Bertolotto, Corine, Eychène, Alain, Druillennec, Sabine

“…The MITF transcription factor and the RAS/RAF/MEK/ERK pathway are two interconnected main players in melanoma. Understanding how MITF activity is regulated…”
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An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma by Morabito, Morgane, Larcher, Magalie, Cavalli, Florence MG, Foray, Chloé, Forget, Antoine, Mirabal‐Ortega, Liliana, Andrianteranagna, Mamy, Druillennec, Sabine, Garancher, Alexandra, Masliah‐Planchon, Julien, Leboucher, Sophie, Debalkew, Abel, Raso, Alessandro, Delattre, Olivier, Puget, Stéphanie, Doz, François, Taylor, Michael D, Ayrault, Olivier, Bourdeaut, Franck, Eychène, Alain, Pouponnot, Celio

“…Medulloblastoma (MB) is a pediatric tumor of the cerebellum divided into four groups. Group 3 is of bad prognosis and remains poorly characterized. While the…”
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NRAS-driven melanoma: A RAF can hide another by Druillennec, Sabine, Pouponnot, Celio, Eychène, Alain

“…Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast,…”
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Alternative Splicing in Oncogenic Kinases: From Physiological Functions to Cancer by Druillennec, Sabine, Dorard, Coralie, Eychène, Alain

“…Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers. Like other eukaryotic genes, oncogenes…”
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B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance by Valluet, Agathe, Druillennec, Sabine, Barbotin, Céline, Dorard, Coralie, Monsoro-Burq, Anne H., Larcher, Magalie, Pouponnot, Celio, Baccarini, Manuela, Larue, Lionel, Eychène, Alain

“…B-Raf and C-Raf kinases have emerged as critical players in melanoma. However, little is known about their role during development and homeostasis of the…”
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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore by Jacotot, E, Ravagnan, L, Loeffler, M, Ferri, K F, Vieira, H L, Zamzami, N, Costantini, P, Druillennec, S, Hoebeke, J, Briand, J P, Irinopoulou, T, Daugas, E, Susin, S A, Cointe, D, Xie, Z H, Reed, J C, Roques, B P, Kroemer, G

“…Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar…”
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Differential Regulation of B-Raf Isoforms by Phosphorylation and Autoinhibitory Mechanisms by Hmitou, Isabelle, Druillennec, Sabine, Valluet, Agathe, Peyssonnaux, Carole, Eychène, Alain

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse by Valluet, Agathe, Hmitou, Isabelle, Davis, Sabrina, Druillennec, Sabine, Larcher, Magalie, Laroche, Serge, Eychène, Alain

“…The B-raf proto-oncogene exerts essential functions during development and adulthood. It is required for various processes, such as placental development,…”
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Evidence of Interactions between the Nucleocapsid Protein NCp7 and the Reverse Transcriptase of HIV-1 by Druillennec, S, Caneparo, A, de Rocquigny, H, Roques, B P

“…The human immunodeficiency virus (HIV-1) nucleocapsid protein NCp7 containing two C X 2 C X 4 H X 4 C-type zinc fingers was proposed to be involved in reverse…”
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Efficient DNA Transfection Mediated by the C-Terminal Domain of Human Immunodeficiency Virus Type 1 Viral Protein R by Kichler, A, Pages, J C, Leborgne, C, Druillennec, S, Lenoir, C, Coulaud, D, Delain, E, Le Cam, E, Roques, B P, Danos, O

“…Author's Correction ( vol. 74 , p. 12003 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Targeting the TNF/IAP pathway synergizes with anti-CD3 immunotherapy in T-cell acute lymphoblastic leukemia by Ávila Ávila, Andrea, Nuantang, Kanokporn, Oliveira, Mariana L., Druillennec, Sabine, Zaniboni, Benedetta, Lengliné, Etienne, Asnafi, Vahid, Ghysdael, Jacques, Tran Quang, Christine

“…•TNF via NF-κB pathway is induced in response to anti-CD3 immunotherapy in patient-derived T-ALL xenografts.•TNF neutralization and the SMAC mimetic birinapant…”
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NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma by Garancher, Alexandra, Lin, Charles Y., Morabito, Morgane, Richer, Wilfrid, Rocques, Nathalie, Larcher, Magalie, Bihannic, Laure, Smith, Kyle, Miquel, Catherine, Leboucher, Sophie, Herath, Nirmitha I., Dupuy, Fanny, Varlet, Pascale, Haberler, Christine, Walczak, Christine, El Tayara, Nadine, Volk, Andreas, Puget, Stéphanie, Doz, François, Delattre, Olivier, Druillennec, Sabine, Ayrault, Olivier, Wechsler-Reya, Robert J., Eychène, Alain, Bourdeaut, Franck, Northcott, Paul A., Pouponnot, Celio

“…Cancer cells often express differentiation programs unrelated to their tissue of origin, although the contribution of these aberrant phenotypes to malignancy…”
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Helical structure determined by NMR of the HIV‐1 (345–392)Gag sequence, surrounding p2: Implications for particle assembly and RNA packaging by Morellet, Nelly, Druillennec, Sabine, Lenoir, Christine, Bouaziz, Serge, Roques, Bernard P.

“…Gag protein oligomerization, an essential step during virus assembly, results in budding of spherical virus particles. This process is critically dependent on…”
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Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2 by Jacotot, Etienne, Ferri, Karine F., El Hamel, Chahrazed, Brenner, Catherine, Druillennec, Sabine, Hoebeke, Johan, Rustin, Pierre, Métivier, Didier, Lenoir, Christine, Geuskens, Maurice, Vieira, Helena L.A., Loeffler, Markus, Belzacq, Anne-Sophie, Briand, Jean-Paul, Zamzami, Naoufal, Edelman, Lena, Xie, Zhi Hua, Reed, John C., Roques, Bernard P., Kroemer, Guido

“…Viral protein R (Vpr), an apoptogenic accessory protein encoded by HIV-1, induces mitochondrial membrane permeabilization (MMP) via a specific interaction with…”
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