Search Results - "Drugs (New York, N.Y.)"

Nirmatrelvir Plus Ritonavir: First Approval by Lamb, Yvette N.

“…Nirmatrelvir plus ritonavir (Paxlovid™; Pfizer) is a co-packaged combination of nirmatrelvir and ritonavir tablets, intended for co-administration and…”
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Patisiran: First Global Approval by Hoy, Sheridan M.

“…Patisiran (ONPATTRO™) is a double-stranded small interfering RNA encapsulated in a lipid nanoparticle for delivery to hepatocytes. By specifically binding to a…”
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Givosiran: First Approval by Scott, Lesley J.

“…Givosiran (Givlaari™) is an aminolevulinate synthase 1 (ALAS1)-directed small interfering RNA (siRNA) covalently linked to a ligand to enable specific delivery…”
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Lumasiran: First Approval by Scott, Lesley J., Keam, Susan J.

“…Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene ( HAO1 ; encodes glycolate…”
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Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli by Zhanel, George G., Golden, Alyssa R., Zelenitsky, Sheryl, Wiebe, Karyn, Lawrence, Courtney K., Adam, Heather J., Idowu, Temilolu, Domalaon, Ronald, Schweizer, Frank, Zhanel, Michael A., Lagacé-Wiens, Philippe R. S., Walkty, Andrew J., Noreddin, Ayman, Lynch III, Joseph P., Karlowsky, James A.

“…Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. As with other β-lactam antibiotics, the…”
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Aducanumab: First Approval by Dhillon, Sohita

“…Aducanumab (aducanumab-avwa; Aduhelm™) is a human, immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of…”
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Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection by Khanna, Sahil, Assi, Maha, Lee, Christine, Yoho, David, Louie, Thomas, Knapple, Whitfield, Aguilar, Humberto, Garcia-Diaz, Julia, Wang, Gary P., Berry, Scott M., Marion, Joe, Su, Xin, Braun, Tricia, Bancke, Lindy, Feuerstadt, Paul

“…Background Recurrent Clostridioides difficile infection, associated with dysbiosis of gut microbiota, has substantial disease burden in the USA. RBX2660 is a…”
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Tazemetostat: First Approval by Hoy, Sheridan M.

“…Tazemetostat (Tazverik™), a first-in-class, small molecule enhancer of zeste homolog 2 (EZH2) inhibitor, received accelerated approval in January 2020 in the…”
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Casimersen: First Approval by Shirley, Matt

“…Casimersen (Amondys 45™) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass developed by Sarepta Therapeutics for the…”
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Imipenem–Relebactam and Meropenem–Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations by Zhanel, George G., Lawrence, Courtney K., Adam, Heather, Schweizer, Frank, Zelenitsky, Sheryl, Zhanel, Michael, Lagacé-Wiens, Philippe R. S., Walkty, Andrew, Denisuik, Andrew, Golden, Alyssa, Gin, Alfred S., Hoban, Daryl J., Lynch, Joseph P., Karlowsky, James A.

“…Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase inhibitor that is structurally related to avibactam,…”
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Onasemnogene Abeparvovec: First Global Approval by Hoy, Sheridan M.

“…Onasemnogene abeparvovec (onasemnogene abeparvovec-xioi; formerly AVXS-101; ZOLGENSMA ® ) is an adeno-associated viral vector-based gene therapy designed to…”
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Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Update on Molecular Epidemiology and Treatment Options by Peirano, Gisele, Pitout, Johann D. D.

“…Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are a major global public health concern. Presently, Escherichia coli with CTX-Ms are the…”
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Sacituzumab Govitecan: First Approval by Syed, Yahiya Y.

“…Sacituzumab govitecan (sacituzumab govitecan-hziy; Trodelvy™) is a Trop-2-directed antibody conjugated to a topoisomerase I inhibitor (SN-38) that is being…”
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Management of Hypertension in Chronic Kidney Disease by Pugh, Dan, Gallacher, Peter J., Dhaun, Neeraj

“…Chronic kidney disease (CKD) is an increasingly prevalent condition globally and is strongly associated with incident cardiovascular disease (CVD)…”
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Golodirsen: First Approval by Heo, Young-A

“…Golodirsen (Vyondys 53 ™ ), an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO) subclass designed to induce exon 53 skipping, has…”
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Camrelizumab: First Global Approval by Markham, Anthony, Keam, Susan J.

“…Camrelizumab (AiRuiKa™), a programmed cell death 1 (PD-1) inhibitor being developed by Jiangsu Hengrui Medicine Co. Ltd, recently received conditional approval…”
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Alpelisib: First Global Approval by Markham, Anthony

“…Alpelisib (Piqray™)—an orally available phosphatidylinositol 3-kinase (PI3K) inhibitor with specific activity against PI3K alpha (PI3Kα)—is being developed by…”
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Lenvatinib: A Review in Hepatocellular Carcinoma by Al-Salama, Zaina T., Syed, Yahiya Y., Scott, Lesley J.

“…Lenvatinib (Lenvima ® ) is an oral small molecule inhibitor of multiple receptor tyrosine kinases, and is approved for the first-line treatment of patients…”
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Pemigatinib: First Approval by Hoy, Sheridan M.

“…Pemigatinib (PEMAZYRE™), a small molecule inhibitor of fibroblast growth factor receptor (FGFR) 1, FGFR2 and FGFR3, received accelerated approval in April 2020…”
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Prevention and Treatment of Monkeypox by Rizk, John G., Lippi, Giuseppe, Henry, Brandon M., Forthal, Donald N., Rizk, Youssef

“…Human monkeypox is a zoonotic orthopoxvirus with presentation similar to smallpox. Monkeypox is transmitted incidentally to humans when they encounter infected…”
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