Search Results - "Drug discoveries & therapeutics"

Discovering drugs to treat coronavirus disease 2019 (COVID-19) by Dong, Liying, Hu, Shasha, Gao, Jianjun

“…The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to…”
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Post COVID-19 sequelae: A prospective observational study from Northern India by Naik, Shivdas, Haldar, Soumendra Nath, Soneja, Manish, Mundadan, Netto George, Garg, Prerna, Mittal, Ankit, Desai, Devashish, Trilangi, Praveen Kumar, Chakraborty, Sayan, Begam, Nazneen Nahar, Bhattacharya, Bisakh, Maher, Ganesh, Mahishi, Niranjan, Rajanna, Chaithra, Kumar, Swasthi S, Arunan, Bharathi, Kirtana, J, Gupta, Ankesh, Patidar, Diksha, Kodan, Parul, Sethi, Prayas, Ray, Animesh, Jorwal, Pankaj, Kumar, Arvind, Nischal, Neeraj, Sinha, Sanjeev, Biswas, Ashutosh, Wig, Naveet

“…Post COVID-19 sequelae are a constellation of symptoms often reported after recovering from COVID-19. There is a need to better understand the clinical…”
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Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future by Tang, Qi, Li, Xueqin, Song, Peipei, Xu, Lingzhong

“…Diabetes mellitus (DM) appears to be increasing rapidly, threatening to reduce life expectancy for humans around the globe. The International Diabetes…”
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Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.) by Ru, Wenwen, Wang, Dongliang, Xu, Yunpeng, He, Xianxian, Sun, Yang-En, Qian, Liyan, Zhou, Xiangshan, Qin, Yufeng

“…Ginseng, Panax ginseng (C. A. Mey.), is a well-known Chinese traditional medicine in the Far East and has gained popularity in the West during the last decade…”
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Role of inulin as prebiotics on inflammatory bowel disease by Akram, Wasim, Garud, Navneet, Joshi, Ramakant

“…The present review is focused on the prebiotic impact of inulin on the management of the gastrointestinal disorder. Prebiotics can be described as…”
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Immunotherapy for hepatocellular carcinoma by Li, Shuzhan, Yang, Fan, Ren, Xiubao

“…Hepatocellular carcinoma (HCC) is the most common type of hepatic malignancies, with poor prognosis. Treatment for HCC are limited, especially for patients…”
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Aducanumab: The first targeted Alzheimer's therapy by Yang, Pan, Sun, Fusheng

“…Alzheimer's disease (AD) is an irreversible brain disorder associated with severe progressive dementia and is characterized by deposits of amyloid plaques in…”
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Treatment of SARS-CoV-2: How far have we reached? by Ahsan, Waquar, Javed, Shamama, Bratty, Mohammed Al, Alhazmi, Hassan A., Najmi, Asim

“…The virus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is currently affecting more than 200 countries and territories worldwide. It has been…”
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Rapid review for the anti-coronavirus effect of remdesivir by Li, Ziyi, Wang, Xiaojie, Cao, Donglin, Sun, Ruilin, Li, Cheng, Li, Guowei

“…The outbreak of SARS-CoV-2 rapidly spread across China and worldwide. Remdesivir had been proposed as a promising option for treating coronavirus disease 2019…”
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"4+7" city drug volume-based purchasing and using pilot program in China and its impact by Tang, Mi, He, Jiangjiang, Chen, Minxing, Cong, Lixuan, Xu, Yuan, Yang, Yan, Hou, Zhiying, Song, Peipei, Jin, Chunlin

“…In order to deepen the health system reform and improve the mechanism for the formation of drug prices, in January 2019, the General Office of the State…”
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Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far? by Zhang, Yuanyuan, Zhong, Yanyan, Pan, Lin, Dong, Jing

“…The world is in the midst of the coronavirus disease 2019 (COVID-19) pandemic. Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the…”
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Polysaccharides: Candidates of promising vaccine adjuvants by Li, Pingli, Wang, Fengshan

“…Aluminium-based adjuvants remain the only adjuvants approved for human use in the USA for over 80 years because of alum's simplicity, tolerability, safety and…”
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LncRNA SNHG1 upregulates FANCD2 and G6PD to suppress ferroptosis by sponging miR-199a-5p/3p in hepatocellular carcinoma by Zhou, Lin, Zhang, Qing, Cheng, Jiaxin, Shen, Xiandie, Li, Jing, Chen, Mingya, Zhou, Chang, JianZhou, Lin

“…Ferroptosis is a form of regulated cell death (RCD) triggered by iron-dependent lipid peroxidation and is closely associated with the occurrence and…”
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Valemetostat: First approval as a dual inhibitor of EZH1/2 to treat adult T-cell leukemia/lymphoma by Dou, Fangzhou, Tian, Zhenxue, Yang, Xu, Li, Jing, Wang, Ruquan, Gao, Jianjun

“…Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell lymphoma with a poor prognosis. Accumulating trimethylation of histone H3 lysine 27 (H3K27me3) caused…”
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Traditional Chinese medicine to treat COVID-19: the importance of evidence-based research by Wang, Jinjing, Qi, Fanghua

“…Coronavirus disease 2019 (COVID-19) broke out in 2019 and spread rapidly around the world, causing a global pandemic. Traditional Chinese medicine has a…”
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Clinical predictors of long COVID-19 and phenotypes of mild COVID-19 at a tertiary care centre in India by Chopra, Neha, Chowdhury, Mohit, Singh, Anupam K, MA, Khan, Kumar, Arvind, Ranjan, Piyush, Desai, Devashish, Wig, Naveet

“…A variable proportion of patients develop persistent/prolonged symptoms of Coronavirus Disease 2019 (COVID-19) infection (long COVID). We aimed to study the…”
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A stroke patient with persistently intermittent fever treated with gabapentin: A clinical case by Huang, Jingjie, Wu, Bangqi, Cheng, Yupei, Wang, Chaoran

“…Fever is one of the most common complications in stroke patients and can generally be classified as either infectious or non-infectious. Infectious fevers are…”
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Padding the seat of a wheelchair reduces ischial pressure and improves sitting comfort by Yoshikawa, Yoshiyuki, Sasaki, Kiyo, Nagayoshi, Kyoko, Nagai, Kenta, Aoyama, Yuki, Takita, Shuto, Wada, Teppei, Kitade, Yoshinori

“…In this study, we aimed to examine whether a wheelchair cushion placed directly atop a sling seat or deflection of the sling seat compensated by a pad along…”
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Novel and emerging therapeutics for antimicrobial resistance: A brief review by Kuchay, Raja Amir Hassan

“…A pandemic known as anti-microbial resistance (AMR) poses a challenge to contemporary medicine. To stop AMR's rise and quick worldwide spread, urgent…”
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Mitotic abnormalities and spindle assembly checkpoint inactivation in a cell model of Shwachman-Diamond syndrome with mutations in the Shwachman-Bodian-Diamond syndrome gene, 258+2T > C by Sera, Yukihiro, Imanaka, Tsuneo, Iguchi, Yusuke, Yamaguchi, Masafumi

“…Hematologic abnormalities are the most common symptoms of Shwachman-Diamond syndrome (SDS). The causative gene for SDS is the Shwachman-Bodian-Diamond syndrome…”
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