Search Results - "Druey, K."

Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection by Ma, M., Redes, J. L., Percopo, C. M., Druey, K. M., Rosenberg, H. F.

“…Summary Background Eosinophils in the nasal mucosa are an elemental feature of allergic rhinitis. Objective Our objective was to explore eosinophilic…”
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RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits by Watson, Ned, Linder, Maurine E, Druey, Kirk M, Kehrl, John H, Blumer, Kendall J

“…Signaling pathways using heterotrimeric guanine-nucleotide-binding-proteins (G proteins) trigger physiological responses elicited by hormones,…”
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Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family by Druey, Kirk M, Blumer, Kendall J, Kang, Veronica H, Kehrl, John H

“…A general property of signal transduction pathways is that prolonged stimulation decreases responsiveness, a phenomenon termed desensitization. Yeast cells…”
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Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization by NEILL, J. D, DUCK, L. W, SELLERS, J. C, MUSGROVE, L. C, SCHESCHONKA, A, DRUEY, K. M, KEHRL, J. H

“…The cellular and molecular mechanisms of gonadotrope desensitization are unknown but transduction of the GnRH signal is known to involve sequentially the GnRH…”
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Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center by TUSCANO, J. M, DRUEY, K. M, RIVA, A, PENA, J, THOMPSON, C. B, KEHRL, J. H

“…Both rapid B-cell proliferation and programmed cell death (PCD) occur during the differentiation and selection of B cells within the germinal center. To help…”
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Mast cells express multiple regulator of G protein signaling (RGS) proteins by Bansal, G., Rao, S., Nocka, K., Druey, K.

“…G-protein-coupled receptors (GPCRs) contribute to the initiation and propagation of allergic processes. Regulators of G Protein Signaling (RGS) proteins…”
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C33 NOVEL BIOMARKERS IN LUNG DISEASE: Aspergillus Fumigatus Alkaline Protease, Alp1 (asp F13) As A Biomarker For Severe Asthma by Basu, T, Druey, K M

“…Asthma, a common respiratory disorder affecting >250 million individuals worldwide, is defined by airway hyper-responsiveness, increased bronchial smooth…”
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RGS16 Function Is Regulated by Epidermal Growth Factor Receptor-mediated Tyrosine Phosphorylation by Derrien, Alexandrine, Druey, Kirk M.

“…Gαi-coupled receptor stimulation results in epidermal growth factor receptor (EGFR) phosphorylation and MAPK activation. Regulators of G protein signaling (RGS…”
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Heterotrimeric G protein signaling: Role in asthma and allergic inflammation by Johnson, Eric N., Druey, Kirk M.

“…Asthma and rhinitis are pathophysiologic conditions associated with a prototypical allergic response to inhaled allergens consisting of both neuromechanical…”
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Regulation of mast cell degranulation in allergic eye disease by IL-10 by Keane-Myers, A.M., Wetzel, B., Druey, K., Bundoc, V.

“…Initial studies showed a panel of commonly used mouse strains, including A/J and C57Bl/6, to have significant variability in the development of allergic eye…”
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Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation by Lippert, Eric, Yowe, David L, Gonzalo, Jose-Angel, Justice, J. Paul, Webster, Jeremy M, Fedyk, Eric R, Hodge, Martin, Miller, Cheryl, Gutierrez-Ramos, Jose-Carlos, Borrego, Francisco, Keane-Myers, Andrea, Druey, Kirk M

“…Chemokine-induced T lymphocyte recruitment to the lung is critical for allergic inflammation, but chemokine signaling pathways are incompletely understood…”
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A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues by HARRISON, K. A, DRUEY, K. M, DEGUCHI, Y, TUSCANO, J. M, KEHRL, J. H

“…A novel human homeobox gene, HB9, was isolated from a cDNA library prepared from in vitro stimulated human tonsil B lymphocytes and from a human genomic…”
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RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport by Sullivan, B M, Harrison-Lavoie, K J, Marshansky, V, Lin, H Y, Kehrl, J H, Ausiello, D A, Brown, D, Druey, K M

“…COPI, a protein complex consisting of coatomer and the small GTPase ARF1, is an integral component of some intracellular transport carriers. The association of…”
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RGS16 inhibits signalling through the G alpha 13-Rho axis by Johnson, Eric N, Seasholtz, Tammy M, Waheed, Abdul A, Kreutz, Barry, Suzuki, Nobuchika, Kozasa, Tohru, Jones, Teresa L Z, Brown, Joan Heller, Druey, Kirk M

“…G alpha 13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF. Activated Rho induces numerous cellular responses, including…”
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Regulation of Chemotactic and Proadhesive Responses to Chemoattractant Receptors by RGS (Regulator of G-protein Signaling) Family Members by Bowman, Edward P., Campbell, James J., Druey, Kirk M., Scheschonka, Astrid, Kehrl, John H., Butcher, Eugene C.

“…Serpentine Gαi-linked receptors support rapid adhesion and directed migration of leukocytes and other cell types. The intracellular mechanisms mediating and…”
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Regulators of G Protein Signaling Exhibit Distinct Patterns of Gene Expression and Target G Protein Specificity in Human Lymphocytes by Beadling, Carol, Druey, Kirk M, Richter, Gunther, Kehrl, John H, Smith, Kendall A

“…The newly recognized regulators of G protein signaling (RGS) attenuate heterotrimeric G protein signaling pathways. We have cloned an IL-2-induced gene from…”
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C35 ASTHMA AND ALLERGY CELLULAR INVESTIGATIONS: Rgs4 Attenuates Allergen-Induced Airway Hyper-Responsiveness In Mice by Wong, G, Madigan, L A, Gordon, E M, Levine, S J, Druey, K M

“…In both WT and TG mice after A.f. inoculation, there were equivalent numbers and composition of inflammatory cells in BALF as well as peribronchial leukocyte…”
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Idiopathic systemic capillary leak syndrome in children by Hsu, Peter, Xie, Zhihui, Frith, Katie, Wong, Melanie, Kakakios, Alyson, Stone, Kelly D, Druey, Kirk M

“…Adult subjects with systemic capillary leak syndrome (SCLS) present with acute and recurrent episodes of vascular leak manifesting as severe hypotension,…”
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Inhibition of Regulator of G Protein Signaling Function by Two Mutant RGS4 Proteins by Druey, Kirk M., Kehrl, John H.

“…Regulators of G protein signaling (RGS) proteins limit the lifetime of activated (GTP-bound) heterotrimeric G protein α subunits by acting as GTPase-activating…”
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Concerted stimulation and deactivation of pertussis toxin‐sensitive G proteins by chimeric G protein‐coupled receptor‐regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4 by Bahia, Daljit S., Sartania, Nana, Ward, Richard J., Cavalli, Antonella, Jones, Teresa L. Z., Druey, Kirk M., Milligan, Graeme

“…Agonists stimulated high‐affinity GTPase activity in membranes of HEK293 cells following coexpression of the α2A‐adrenoceptor and a pertussis toxin‐resistant…”
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