Search Results - "Drouyer, Matthieu"

LRRK2 Phosphorylation, More Than an Epiphenomenon by Marchand, Antoine, Drouyer, Matthieu, Sarchione, Alessia, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc

“…Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus…”
Get full text

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation by Drouyer, Matthieu, Bolliger, Marc F., Lobbestael, Evy, Van den Haute, Chris, Emanuele, Marco, Lefebvre, Réginald, Sibran, William, De Wit, Tina, Leghay, Coline, Mutez, Eugénie, Dzamko, Nicolas, Halliday, Glenda M., Murayama, Shigeo, Martoriati, Alain, Cailliau, Katia, Bodart, Jean-François, Chartier-Harlin, Marie-Christine, Baekelandt, Veerle, Nichols, R. Jeremy, Taymans, Jean-Marc

“…LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD)…”
Get full text

Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8 by Cabanes-Creus, Marti, Navarro, Renina Gale, Zhu, Erhua, Baltazar, Grober, Liao, Sophia H.Y., Drouyer, Matthieu, Amaya, Anais K., Scott, Suzanne, Nguyen, Loan Hanh, Westhaus, Adrian, Hebben, Matthias, Wilson, Laurence O.W., Thrasher, Adrian J., Alexander, Ian E., Lisowski, Leszek

“…Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical…”
Get full text

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation by Iannotta, Lucia, Emanuele, Marco, Favetta, Giulia, Tombesi, Giulia, Vandewynckel, Laurine, Lara Ordóñez, Antonio Jesús, Saliou, Jean-Michel, Drouyer, Matthieu, Sibran, William, Civiero, Laura, Nichols, R Jeremy, Athanasopoulos, Panagiotis S, Kortholt, Arjan, Chartier-Harlin, Marie-Christine, Greggio, Elisa, Taymans, Jean-Marc

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson's disease (PD) and previous work suggests that…”
Get full text

Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2 by Cabanes-Creus, Marti, Westhaus, Adrian, Navarro, Renina Gale, Baltazar, Grober, Zhu, Erhua, Amaya, Anais K., Liao, Sophia H.Y., Scott, Suzanne, Sallard, Erwan, Dilworth, Kimberley L., Rybicki, Arkadiusz, Drouyer, Matthieu, Hallwirth, Claus V., Bennett, Antonette, Santilli, Giorgia, Thrasher, Adrian J., Agbandje-McKenna, Mavis, Alexander, Ian E., Lisowski, Leszek

“…Use of the prototypical adeno-associated virus type 2 (AAV2) capsid delivered unexpectedly modest efficacy in an early liver-targeted gene therapy trial for…”
Get full text

Novel AAV variants with improved tropism for human Schwann cells by Drouyer, Matthieu, Chu, Tak-Ho, Labit, Elodie, Haase, Florencia, Navarro, Renina Gale, Nazareth, Deborah, Rosin, Nicole, Merjane, Jessica, Scott, Suzanne, Cabanes-Creus, Marti, Westhaus, Adrian, Zhu, Erhua, Midha, Rajiv, Alexander, Ian E., Biernaskie, Jeff, Ginn, Samantha L., Lisowski, Leszek

“…Gene therapies and associated technologies are transforming biomedical research and enabling novel therapeutic options for patients living with debilitating…”
Get full text

Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids by Cabanes-Creus, Marti, Navarro, Renina Gale, Liao, Sophia H.Y., Baltazar, Grober, Drouyer, Matthieu, Zhu, Erhua, Scott, Suzanne, Luong, Clement, Wilson, Laurence O.W., Alexander, Ian E., Lisowski, Leszek

“…Recent successes in clinical gene therapy applications have intensified the interest in using adeno-associated viruses (AAVs) as vectors for gene delivery into…”
Get full text

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively by Marchand, Antoine, Sarchione, Alessia, Athanasopoulos, Panagiotis S, Roy, Hélène Bauderlique-Le, Goveas, Liesel, Magnez, Romain, Drouyer, Matthieu, Emanuele, Marco, Ho, Franz Y, Liberelle, Maxime, Melnyk, Patricia, Lebègue, Nicolas, Thuru, Xavier, Nichols, R Jeremy, Greggio, Elisa, Kortholt, Arjan, Galli, Thierry, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc

“…The ( ) gene is a major genetic determinant of Parkinson's disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and…”
Get full text

Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice by Drouyer, Matthieu, Merjane, Jessica, Nazareth, Deborah, Knight, Maddison, Scott, Suzanne, Liao, Sophia H Y, Ginn, Samantha L, Zhu, Erhua, Alexander, Ian E, Lisowski, Leszek

“…Directed evolution of natural AAV9 using peptide display libraries have been widely used in the search for an optimal recombinant AAV (rAAV) for transgene…”
Get more information

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2 by Blanca Ramírez, Marian, Lara Ordóñez, Antonio Jesús, Fdez, Elena, Madero-Pérez, Jesús, Gonnelli, Adriano, Drouyer, Matthieu, Chartier-Harlin, Marie-Christine, Taymans, Jean-Marc, Bubacco, Luigi, Greggio, Elisa, Hilfiker, Sabine

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the most common cause of familial Parkinson's disease (PD), and sequence variants modify risk for…”
Get full text

LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker? by Taymans, Jean-Marc, Mutez, Eugénie, Drouyer, Matthieu, Sibran, William, Chartier-Harlin, Marie-Christine

“…Leucine-rich repeat kinase 2 (LRRK2) is a complex signalling protein that is a key therapeutic target, particularly in Parkinson's disease (PD). In addition,…”
Get more information

Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations by Drouyer, Matthieu, Merjane, Jessica, Nedelkoska, Teodora, Westhaus, Adrian, Scott, Suzanne, Lee, Scott, Burke, Peter G.R., McMullan, Simon, Lanciego, Jose L., Vicente, Ana F., Bugallo, Ricardo, Unzu, Carmen, González-Aseguinolaza, Gloria, Gonzalez-Cordero, Anai, Lisowski, Leszek

“…Viral vectors based on recombinant adeno-associated virus (rAAV) have become the most widely used system for therapeutic gene delivery in the central nervous…”
Get full text

Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy by Sargent, Dorian, Bétemps, Dominique, Drouyer, Matthieu, Verchere, Jérémy, Gaillard, Damien, Arsac, Jean-Noël, Lakhdar, Latifa, Salvetti, Anna, Baron, Thierry

“…Parkinson’s disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases characterized by inclusions mainly composed of α-synuclein (α-syn)…”
Get full text

Phosphatome-wide siRNA screen reveals phosphorylation regulators of the Parkinson’s disease protein LRRK2 by De Wit, Tina, Lobbestael, Evy, Böllliger, Marc, Drouyer, Matthieu, Chartier-Harlin, Marie-Christine, Nichols, R. Jeremy, Taymans, Jean-Marc, Baekelandt, Veerle

“…Abstract only…”
Get full text