Search Results - "Drost, Rinske"

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors by Jaspers, Janneke E, Kersbergen, Ariena, Boon, Ute, Sol, Wendy, van Deemter, Liesbeth, Zander, Serge A, Drost, Rinske, Wientjens, Ellen, Ji, Jiuping, Aly, Amal, Doroshow, James H, Cranston, Aaron, Martin, Niall M B, Lau, Alan, O'Connor, Mark J, Ganesan, Shridar, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

“…Inhibition of PARP is a promising therapeutic strategy for homologous recombination-deficient tumors, such as BRCA1-associated cancers. We previously reported…”
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BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance by Drost, Rinske, Bouwman, Peter, Rottenberg, Sven, Boon, Ute, Schut, Eva, Klarenbeek, Sjoerd, Klijn, Christiaan, van der Heijden, Ingrid, van der Gulden, Hanneke, Wientjens, Ellen, Pieterse, Mark, Catteau, Aurelie, Green, Pete, Solomon, Ellen, Morris, Joanna R., Jonkers, Jos

“…Hereditary breast cancers are frequently caused by germline BRCA1 mutations. The BRCA1 C61G mutation in the BRCA1 RING domain is a common pathogenic missense…”
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Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin by Evers, Bastiaan, Drost, Rinske, Schut, Eva, de Bruin, Michiel, van der Burg, Eline, Derksen, Patrick W B, Holstege, Henne, Liu, Xiaoling, van Drunen, Ellen, Beverloo, H Berna, Smith, Graeme C M, Martin, Niall M B, Lau, Alan, O'Connor, Mark J, Jonkers, Jos

“…Purpose: To assess efficacy of the novel, selective poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor AZD2281 against newly established BRCA2-deficient mouse…”
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Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice by Pajic, Marina, Blatter, Sohvi, Guyader, Charlotte, Gonggrijp, Maaike, Kersbergen, Ariena, Küçükosmanoğlu, Aslι, Sol, Wendy, Drost, Rinske, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

“…Abstract Purpose: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse…”
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Challenging Future Generations: A Qualitative Study of Students' Attitudes toward the Transition to Animal-Free Innovations in Education and Research by Andreoli, Lara, Vlasblom, Ronald, Drost, Rinske, Meijboom, Franck L B, Salvatori, Daniela

“…In 2016, the Dutch government declared its commitment to phasing out animal experiments by 2025. Although a high number of animal experiments are still…”
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Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer by Bowman-Colin, Christian, Xia, Bing, Bunting, Samuel, Klijn, Christiaan, Drost, Rinske, Bouwman, Peter, Fineman, Laura, Chen, Xixi, Culhane, Aedin C., Cai, Hong, Rodig, Scott J., Bronson, Roderick T., Jonkers, Jos, Nussenzweig, Andre, Kanellopoulou, Chryssa, Livingston, David M.

“…Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor…”
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BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K., van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H.W., Demmers, Jeroen A.A., van Gent, Dik C., Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

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BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K, van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H W, Demmers, Jeroen A A, van Gent, Dik C, Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

“…Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break…”
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Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model by Vlasblom, Ronald, van Thiel, Jory, Bittenbinder, Matyas A., van Rhijn, Jon-Ruben, Drost, Rinske, Muis, Lotte, Slagboom, Julien, Salvatori, Daniela, Kool, Jeroen, Veldman, Robert Jan

“…Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox)…”
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Selected Alkylating Agents Can Overcome Drug Tolerance of G 0 -like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice by Pajic, Marina, Blatter, Sohvi, Guyader, Charlotte, Gonggrijp, Maaike, Kersbergen, Ariena, Küçükosmanoğlu, Aslι, Sol, Wendy, Drost, Rinske, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

“…We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse. We studied responses to…”
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A high-throughput functional complementation assay for classification of BRCA1 missense variants by Bouwman, Peter, van der Gulden, Hanneke, van der Heijden, Ingrid, Drost, Rinske, Klijn, Christiaan N, Prasetyanti, Pramudita, Pieterse, Mark, Wientjens, Ellen, Seibler, Jost, Hogervorst, Frans B L, Jonkers, Jos

“…Mutations in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian cancers, and therefore sequence analysis of both genes is routinely…”
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BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A by Puppe, Julian, Drost, Rinske, Liu, Xiaoling, Joosse, Simon A, Evers, Bastiaan, Cornelissen-Steijger, Paulien, Nederlof, Petra, Yu, Qiang, Jonkers, Jos, van Lohuizen, Maarten, Pietersen, Alexandra M

“…Treatment of breast cancer is becoming more individualized with the recognition of tumor subgroups that respond differently to available therapies. Breast…”
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Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression by Bouwman, Peter, Drost, Rinske, Klijn, Christiaan, Pieterse, Mark, Gulden, Hanneke van der, Song, Ji-Ying, Szuhai, Karoly, Jonkers, Jos

“…PALB2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a…”
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BRCA1^sup 185delAG^ tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K, van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H W, Demmers, Jeroen A A, van Gent, Dik C, Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

“…Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break…”
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tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K, van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H.W, Demmers, Jeroen A.A, van Gent, Dik C, Agami, Reuven, Balmana, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

“…Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break…”
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BRCA1 super( 185delAG) tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K, van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H W, Demmers, Jeroen A A, van Gent, Dik C, Agami, Reuven, Balmana, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

“…Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break…”
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Each of the four intracellular cysteines of CD36 is essential for insulin- or AMP-activated protein kinase-induced CD36 translocation by van Oort, Masja M., Drost, Rinske, Janβen, Linda, Van Doorn, Jan M., Kerver, Jana, Van der Horst, Dick J., Luiken, Joost J. F. P., Rodenburg, Kees (C.) W.

“…Abstract Stimulation of cellular fatty acid uptake by induction of insulin signalling or AMP-kinase (AMPK) activation is due to translocation of the fatty…”
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Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth byAZD2281 and Cisplatin by EVERS, Bastiaan, DROST, Rinske, SMITH, Graeme C. M, MARTIN, Niall M. B, LAU, Alan, O'CONNOR, Mark J, JONKERS, Jos, SCHUT, Eva, DE BRUIN, Michiel, VAN DER BURG, Eline, DERKSEN, Patrick W. B, HOLSTEGE, Henne, XIAOLING LIU, VAN DRUNEN, Ellen, BERNA BEVERLOO, H

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