Search Results - "Drost, E. M"

Oxidative stress and airway inflammation in severe exacerbations of COPD by Drost, E M, Skwarski, K M, Sauleda, J, Soler, N, Roca, J, Agusti, A, MacNee, W

“…Background: A study was undertaken to assess both oxidative stress and inflammation in the lungs of patients with chronic obstructive pulmonary disease (COPD)…”
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Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways by Mroz, R. M, Schins, R. P. F, Li, H, Jimenez, L. A, Drost, E. M, Holownia, A, MacNee, W, Donaldson, K

“…The epidemiological association between cancer and exposure to ambient air pollution particles (particles with a 50% cut-off aerodynamic diameter of 10 microm…”
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Activation of NF-κB by PM10 Occurs via an Iron-Mediated Mechanism in the Absence of IκB Degradation by Jiménez, L.A., Thompson, J., Brown, D.A., Rahman, I., Antonicelli, F., Duffin, R., Drost, E.M., Hay, R.T., Donaldson, K., MacNee, W.

“…Exposureto particulate air pollution (PM10) is associated with exacerbations of respiratory diseases and increased cardiopulmonary mortality. PM10 induces lung…”
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Increased rigidity and priming of polymorphonuclear leukocytes in sepsis by DROST, E. M, KASSABIAN, G, MEISELMAN, H. J, GELMONT, D, FISHER, T. C

“…It has been proposed that abnormal mechanical properties may contribute to capillary retention of polymorphonuclear leukocytes (PMN) in sepsis, leading to the…”
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Diminished peroxisome proliferator-activated receptor (PPAR) regulation as a potential mechanism for the persistent inflammation in chronic obstructive pulmonary disease by Drost, E. M, Poland, C. A, Donaldson, K, MacNee, W

“…ELEGI/Colt Research Laboratories, MRC/University of Edinburgh Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK…”
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Rheological response of neutrophils to different types of stimulation by Buttrum, S M, Drost, E M, MacNee, W, Goffin, E, Lockwood, C M, Hatton, R, Nash, G B

“…The potential for neutrophils to obstruct microvessels was evaluated by measuring transit of individual neutrophils through 8-microns pores in an automated…”
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Role of accelerated aging in limb muscle wasting of patients with COPD by Lakhdar, Ramzi, McGuinness, Dagmara, Drost, Ellen M, Shiels, Paul G, Bastos, Ricardo, MacNee, William, Rabinovich, Roberto A

“…Skeletal muscle wasting is an independent predictor of health-related quality of life and survival in patients with COPD, but the complexity of molecular…”
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Home monitoring of breathing rate in people with chronic obstructive pulmonary disease: observational study of feasibility, acceptability, and change after exacerbation by Rubio, Noah, Parker, Richard A, Drost, Ellen M, Pinnock, Hilary, Weir, Christopher J, Hanley, Janet, Mantoani, Leandro C, MacNee, William, McKinstry, Brian, Rabinovich, Roberto A

“…Telehealth programs to promote early identification and timely self-management of acute exacerbations of chronic obstructive pulmonary diseases (AECOPDs) have…”
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Potential role of IL‐8, platelet‐activating factor and TNF‐α in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis by Drost, Ellen M., MacNee, William

“…The microvasculature of the normal lung contains a pool of sequestered neutrophils, which is markedly enhanced in acute lung inflammation. Lung neutrophil…”
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Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles by Gilmour, Peter S, Ziesenis, Axel, Morrison, E.Rona, Vickers, Mark A, Drost, Ellen M, Ford, Isobel, Karg, Erwin, Mossa, Claudia, Schroeppel, Andreas, Ferron, George A, Heyder, Joachim, Greaves, Michael, MacNee, William, Donaldson, Kenneth

“…While environmental particles are associated with mortality and morbidity related to pulmonary and cardiovascular (CV) disease, the mechanisms involved in CV…”
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Changes in neutrophil deformability following in vitro smoke exposure: mechanism and protection by Drost, E M, Selby, C, Lannan, S, Lowe, G D, MacNee, W

“…We have previously demonstrated a reduction in the deformability of neutrophils, exposed to whole particulate cigarette smoke in vitro, by measuring their…”
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Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease by Mroz, R M, Holownia, A, Chyczewska, E, Drost, E M, Braszko, J J, Noparlik, J, Donaldson, K, Macnee, W

“…cAMP responsive element binding protein (CREB) plays an important role in transcriptional machinery. CREB signaling is altered in patients with asthma…”
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The effect of lipocortin 1 on neutrophil deformability by Drost, E M, Macnee, W, Smith, S F

“…LIPOCORTN 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to…”
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Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells by Lapperre, Thérèse S, Jimenez, Luis A, Antonicelli, Frank, Drost, Ellen M, Hiemstra, Pieter S, Stolk, Jan, MacNee, William, Rahman, Irfan

“…Apocynin (4-hydroxy-3-methoxy-acetophenone) is a potent intracellular inhibitor of superoxide anion production in neutrophils. In this study, we studied the…”
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Potential pro‐inflammatory effects of soluble E‐selectin upon neutrophil function by Ruchaud‐Sparagano, Marie‐Hélène, Drost, Ellen M., Donnelly, Seamas C., Bird, Michael I., Haslett, Christopher, Dransfield, Ian

“…Appropriate recruitment of neutrophils to sites of infection or tissue injury is a key event in the inflammatory response. A number of studies have shown the…”
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The Effect of Smoking on the Transcriptional Regulation of Lung Inflammation in Patients with Chronic Obstructive Pulmonary Disease by Szulakowski, Patryk, Crowther, Ann J. L, Jimenez, Luis A, Donaldson, Kenneth, Mayer, Ruth, Leonard, Thomas B, MacNee, William, Drost, Ellen M

“…Chronic obstructive pulmonary disease (COPD) is believed to result from an abnormal inflammatory response in the lungs to noxious particles and gases usually…”
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Decreased leukocyte deformability after acute cigarette smoking in humans by Drost, E M, Selby, C, Bridgeman, M M, MacNee, W

“…Acute cigarette smoking increases the sequestration of neutrophils in the lungs of humans. This may be due to the delayed transit of cells in the pulmonary…”
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Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line by Mroz, R M, Schins, R P F, Li, H, Drost, E M, Macnee, W, Donaldson, K

“…To assess whether nanoparticle (NP) driven DNA damage induces the expression of proinflammatory transcription factors such as NFB and AP-1 A549, lung…”
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Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn by Antonicelli, Frank, Brown, David, Parmentier, Maryline, Drost, Ellen M, Hirani, Nik, Rahman, Irfan, Donaldson, Ken, MacNee, William

“…Increased levels of proinflammatory cytokines are present in bronchoalveolar lavage fluid in various lung diseases. Redox-sensitive transcription factors such…”
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PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha by Jiménez, L A, Drost, E M, Gilmour, P S, Rahman, I, Antonicelli, F, Ritchie, H, MacNee, W, Donaldson, K

“…There is now considerable evidence for an association between the levels of particulate air pollution [particulate matter <10 microm in aerodynamic diameter…”
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