Search Results - "Dronina, Maria"
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Glutamine Homeostasis and Its Role in the Adaptive Strategies of the Blind Mole Rat, Spalax
Published in Metabolites (31-10-2021)“…Oxidative metabolism is fine-tuned machinery that combines two tightly coupled fluxes of glucose and glutamine-derived carbons. Hypoxia interrupts the…”
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Comprehensive Analysis of 13C6 Glucose Fate in the Hypoxia-Tolerant Blind Mole Rat Skin Fibroblasts
Published in Metabolites (27-10-2021)“…The bioenergetics of the vast majority of terrestrial mammals evolved to consuming glucose (Glc) for energy production under regular atmosphere (about 21%…”
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Evolution of inhibitor-resistant natural mutant forms of HIV-1 protease probed by pre-steady state kinetic analysis
Published in Biochimie (01-11-2017)“…Pre-steady state kinetic analysis of mechanistic features of substrate binding and processing is crucial for insight into the evolution of inhibitor-resistant…”
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Heavy-light chain interrelations of MS-associated immunoglobulins probed by deep sequencing and rational variation
Published in Molecular immunology (01-12-2014)“…The mechanisms triggering most of autoimmune diseases are still obscure. Autoreactive B cells play a crucial role in the development of such pathologies and,…”
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Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax
Published in Aging cell (01-01-2020)“…The blind mole rat (Spalax) is a wild, long‐lived rodent that has evolved mechanisms to tolerate hypoxia and resist cancer. Previously, we demonstrated high…”
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Novel antibacterial proteins from entomocidal crystals of Bacillus thuringiensis ssp. israelensis
Published in Canadian journal of microbiology (01-02-2005)“…Proteins with molecular masses of 36 and 34 kDa (Bti36 and Bti34) were isolated from entomocidal crystals formed by Bacillus thuringiensis ssp. israelensis…”
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Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs
Published in Biotechnology letters (01-07-2016)“…Objective Myelin oligodendrocyte glycoprotein (MOG) is one of the major autoantigens in multiple sclerosis (MS), therefore selective depletion of autoreactive…”
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