Search Results - "Drolet, D W"

Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys by DROLET, Daniel W, NELSON, Joyce, BENDELE, Raymond A, TUCKER, Christopher E, ZACK, Philip M, NIXON, Kerry, BOLIN, Richard, JUDKINS, Mark B, FARMER, James A, WOLF, Julie L, GILL, Stanley C

“…The objective of this study was to determine the pharmacokinetics and safety for NX1838 following injection into the vitreous humor of rhesus monkeys. Plasma…”
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Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma by FALK, S, ANTHONEY, A, AJANI, J, EATOCK, M, VAN CUTSEM, E, CHICK, J, GLEN, H, VALLE, J. W, DROLET, D. W, ALBERT, D, FERRY, D

“…A two-stage Simon design was used to evaluate the response rate of OSI-7904L, a liposome encapsulated thymidylate synthase inhibitor, in advanced gastric…”
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A high throughput platform for systematic evolution of ligands by exponential enrichment (SELEX) by Drolet, D W, Jenison, R D, Smith, D E, Pratt, D, Hicke, B J

“…The systematic evolution of ligands by exponential enrichment (SELEX) process is a combinatorial chemistry method for the isolation of nucleic acid ligands…”
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A phase I, first in man study of OSI-7836 in patients with advanced refractory solid tumors : IND.147, a study of the Investigational New Drug Program of the National Cancer Institute of Canada Clinical Trials Group by GOSS, G, SIU, L. L, DROLET, D. W, RUSK, J, SEYMOUR, L. K, GAUTHIER, I, CHEN, E. X, OZA, A. M, GOEL, R, MAROUN, J, POWERS, J, WALSH, W, MACLEAN, M

“…To determine the maximum tolerated dose (MTD), recommended phase II dose (RP2D), safety, tolerability, toxicity profile, dose-limiting toxicities (DLTs),…”
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TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins by DROLET, D. W, SCULLY, K. M, SIMMONS, D. M, WEGNER, M, KETING CHU, SWANSON, L. W, ROSENFELD, M. G

“…We have identified and characterized a new member of the leucine zipper (bZIP) gene family of transcription factors, thyrotroph embryonic factor (TEF)…”
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Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope by SHENG-CAI LIN, SEN LI, DROLET, D. W, ROSENFELD, M. G

“…The anterior pituitary provides a model to study the molecular mechanisms responsible for emergence of distinct cell types within an organ. Dwarf mice (Snell)…”
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Regulation of JC Virus by the POU-Domain Transcription Factor Tst-1: Implications for Progressive Multifocal Leukoencephalopathy by Wegner, Michael, Drolet, Daniel W., Rosenfeld, Michael G.

“…Progressive multifocal leukoencephalopathy results from an opportunistic infection of myelin-producing oligodendrocytes by the glia-specific human papovavirus…”
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Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice by Hitzler, Johann K., Soares, Holly D., Drolet, Daniel W., Inaba, Toshiya, O'Connel, Shawn, G. Rosenfeld, Michael, Morgan, James I., Look, A.Thomas

“…Hepatic leukemia factor (HLF) is a bZIP transcription factor related to the CES-2 protein, which controls apoptosis of the NSM serotoninergic neurons in…”
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An enzyme-linked oligonucleotide assay by Drolet, Daniel W, Moon-McDermott, Lotus, Romig, Timothy S

“…The recent development of in vitro methods to select high-affinity ligands by combinatorial chemistry methodologies promises unique and theoretically unlimited…”
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An enzyme-linked immunosorbent assay to study human relaxin in human pregnancy and in pregnant rhesus monkeys by Lucas, C, Bald, L N, Martin, M C, Jaffe, R B, Drolet, D W, Mora-Worms, M, Bennett, G, Chen, A B, Johnston, P D

“…A sensitive and specific double-antibody enzyme-linked immunoassay, using a synthetic analogue of human relaxin for standard and immunogen, was developed for…”
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Aptamer affinity chromatography:: combinatorial chemistry applied to protein purification by Romig, Timothy S, Bell, Carol, Drolet, Daniel W

“…The systematic evolution of ligands by exponential enrichment process is a combinatorial chemistry method that allows the identification of specific…”
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Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys by Tucker, Christopher E., Chen, Long-Shiuh, Judkins, Mark B., Farmer, James A., Gill, Stanley C., Drolet, Daniel W.

“…Aptamers are oligonucleotide ligands selected, in vitro, to bind a specified target protein. The first aptamer to reach human clinical testing is NX1838, a…”
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Safety Assessment of 4′-Thio-β-d-Arabinofuranosylcytosine in the Beagle Dog Suggests a Drug-Induced Centrally Mediated Effect on the Hypothalamic-Pituitary-Adrenal Axis by Colagiovanni, Dorothy B., Drolet, Daniel W., Dihel, Larry, Meyer, Dennis J., Hart, Karen, Wolf, Julie

“…4′-Thio-β-d-arabinofuranosylcytosine (OSI-7836) is a nucleoside analogue with structural similarity to gemcitabine and cytarabine (ara-C). Myelosuppression,…”
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Reduced Fertility in Mice Deficient for the POU Protein Sperm-1 by Pearse, Richard V., Drolet, Daniel W., Kalla, Kristin A., Hooshmand, Farideh, Bermingham, John R., Rosenfeld, Michael G.

“…Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ…”
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Increase in Cyclic AMP Levels by Relaxin in Newborn Rhesus Monkey Uterus Cell Culture by Susan Mukavitz Kramer, Ursula E. M. Gibson, Fendly, Brian M., Marjorie A. Mohler, Drolet, Daniel W., Johnston, Paul D.

“…A novel relaxin sensitive cell line of apparent smooth muscle origin has been established from a newborn rhesus monkey uterus (NRMU). NRMU cells respond to…”
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Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice by Lira, S A, Kalla, K A, Glass, C K, Drolet, D W, Rosenfeld, M G

“…The role of the pituitary-specific POU-domain protein, Pit-1, in GH gene activation has been established by in vitro analyses and by the observation that…”
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Purification of a highly modified RNA-aptamer: Effect of complete denaturation during chromatography on product recovery and specific activity by Bridonneau, Philippe, Bunch, Steve, Tengler, Robert, Hill, Ken, Carter, Jeff, Pieken, Wolfgang, Tinnermeier, David, Lehrman, Russ, Drolet, Daniel W.

“…To evaluate RNA-aptamers as potential drug candidates, efficient and scaleable purification protocols are needed. Because aptamers are highly structured and…”
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POU-domain proteins: structure and function of developmental regulators by Wegner, M, Drolet, D W, Rosenfeld, M G

“…POU-domain proteins are a group of developmental regulators found in organisms as distant as worm and man. The sequence conservation of the POU-domain has…”
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Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

“…Recent studies have suggested that vascular endothelial growth factor (VEGF) is an important stimulus for the growth of new blood vessels in the eye. Anti-VEGF…”
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The effect of changes in muscle function and bone growth on muscle migration by Grant, P G, Buschang, P H, Drolet, D W, Pickerell, C

“…The elastic sleeve model of the periosteum of a long bone presents the periosteum as a structure which, because it is attached to the epiphyses rather than the…”
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