An Outbreak of Trichophyton quinckeanum Zoonotic Infections in the Czech Republic Transmitted from Cats and Dogs

a zoophilic dermatophyte mostly known as the causative agent of rodent favus, is relatively rarely reported to cause human infections. Indeed, no infections were detected in Czechia between 2012 and 2015 despite routine verification of species identification by ITS rDNA sequencing. By contrast, 25 h...

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Published in:	Journal of fungi (Basel) Vol. 7; no. 9; p. 684
Main Authors:	Lysková, Pavlína, Dobiáš, Radim, Čmoková, Adéla, Kolařík, Miroslav, Hamal, Petr, Šmatláková, Kateřina, Hušek, Jan, Mencl, Karel, Mallátová, Nad'a, Poláčková, Zora, Krnáčová, Anežka, Palkovičová, Kristýna, Jablonská, Daniela, Macháčová, Jitka, Drlík, Zdeněk, Bázsóová, Denisa, Jaworská, Pavla, Svobodová, Lucie, Hubka, Vit
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25-08-2021 MDPI
Subjects:	Amorolfine antifungal susceptibility testing EUCAST Fluconazole Infections Ketoconazole Laboratories Mass spectrometry Morphology Outbreaks Pathogens Physiology Scientific imaging Soil pollution Terbinafine tinea capitis tinea corporis zoophilic dermatophytes Czech Republic United Kingdom > UK United States > US Germany EUCAST terbinafine tinea capitis zoonotic infections MALDI-TOF mass spectrometry zoophilic dermatophytes antifungal susceptibility testing tinea corporis
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Summary:	a zoophilic dermatophyte mostly known as the causative agent of rodent favus, is relatively rarely reported to cause human infections. Indeed, no infections were detected in Czechia between 2012 and 2015 despite routine verification of species identification by ITS rDNA sequencing. By contrast, 25 human and 11 animal cases of infection were documented from December 2016 to December 2020 and the rates tended to grow every following year. Interestingly, most of the cases were reported in the Olomouc region, suggesting a local outbreak. We bring the evidence that human infections are most commonly contracted from infected cats or, less frequently, dogs. Although rodents or contaminated soil and environment could be the source of infection to cats and dogs, the occurrence of infections in multiple animals in the same household suggests direct transmission among animals. Confirmation of the identification by molecular methods is highly recommended due to morphological similarity with . Antifungal susceptibility testing of isolates to eight antifungals was performed using EUCAST methodology (E.Def 11.0). Among the tested antifungals, terbinafine, amorolfine, ciclopirox and efinaconazole were most potent in vitro and elevated minimum inhibitory concentrations were obtained for fluconazole and ketoconazole.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 P.L. and R.D. contributed equally to this article.
ISSN:	2309-608X 2309-608X
DOI:	10.3390/jof7090684