Search Results - "Driscoll, K E"

Intratracheal Instillation as an Exposure Technique for the Evaluation of Respiratory Tract Toxicity: Uses and Limitations by Driscoll, Kevin E., Costa, Daniel L., Hatch, Gary, Henderson, Rogene, Oberdorster, Gunter, Salem, Harry, Schlesinger, Richard B.

“…The evaluation of respiratory tract toxicity from airborne materials frequently involves exposure of animals via inhalation. This provides a natural route of…”
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Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica by JOHNSTON, C. J, DRISCOLL, K. E, FINKELSTEIN, J. N, BAGGS, R, O'REILLY, M. A, CARTER, J, GELEIN, R, OBERDÖRSTER, G

“…Chronic inhalation of crystalline silica can produce lung tumors in rats whereas this has not been shown for amorphous silica. At present the mechanisms…”
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Cytokines and Particle-Induced Inflammatory Cell Recruitment by Driscoll, Kevin E., Carter, Janet M., Hassenbein, Diana G., Howard, Brian

“…The inflammatory response is a key component of host defense. However, excessive or persistent inflammation can contribute to the pathogenesis of disease…”
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Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells by DRISCOLL, K. E, DEYO, L. C, CARTER, J. M, HOWARD, B. W, HASSENBEIN, D. G, BERTRAM, T. A

“…To investigate mechanisms underlying development of lung adenomas and carcinomas in rats exposed to poorly soluble particles the relationships between particle…”
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Macrophage inflammatory proteins: biology and role in pulmonary inflammation by Driscoll, K E

“…Macrophage inflammatory proteins 1 alpha and beta (MIP-1 alpha and beta) and macrophage inflammatory protein 2 (MIP-2) are approximately 6-8 kd, heparin…”
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Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation by Xing, Z, Jordana, M, Kirpalani, H, Driscoll, K E, Schall, T J, Gauldie, J

“…Using a rat model of acute lung inflammation induced by intratracheal instillation of lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression…”
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Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells by Janssen, YM, Driscoll, KE, Howard, B, Quinlan, TR, Treadwell, M, Barchowsky, A, Mossman, BT

“…The mechanisms of cell signaling and altered gene expression by asbestos, a potent inflammatory, fibrogenic, and carcinogenic agent, are unclear. Activation of…”
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Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen by Driscoll, K E, Hassenbein, D G, Howard, B W, Isfort, R J, Cody, D, Tindal, M H, Suchanek, M, Carter, J M

“…Macrophage inflammatory protein-2 (MIP-2) is a member of a family of cytokines that play roles in inflammatory, immune, and wound healing responses. To clone…”
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Pulmonary Inflammatory, Chemokine, and Mutagenic Responses in Rats after Subchronic Inhalation of Carbon Black by Driscoll, Kevin E., Carter, Janet M., Howard, Brian W., Hassenbein, Diana G., Pepelko, William, Baggs, Raymond B., Oberdörster, Günter

“…Chronic inhalation of carbon black can produce carcinomas in rat lungs. At present the mechanisms underlying the rat lung tumor response to carbon black are…”
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Asbestos Induces Nuclear Factor κB (NF-κB) DNA-Binding Activity and NF-κB-Dependent Gene Expression in Tracheal Epithelial Cells by Yvonne M. W. Janssen, Barchowsky, Aaron, Treadwell, Melinda, Driscoll, Kevin E., Mossman, Brooke T.

“…Nuclear factor κB (NF-κB) is a transcription factor regulating expression of genes intrinsic to inflammation and cell proliferation-features of…”
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Alpha-quartz-induced chemokine expression by rat lung epithelial cells: effects of in vivo and in vitro particle exposure by Driscoll, KE, Howard, BW, Carter, JM, Asquith, T, Johnston, C, Detilleux, P, Kunkel, SL, Isfort, RJ

“…Chemokines are chemotactic cytokines that can play a key role in leukocyte recruitment to sites of tissue injury or infection. Previous studies have…”
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The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison by Carter, J M, Driscoll, K E

“…To gain a better understanding of the complex mechanisms at work in silica-induced lung disease, we conducted studies comparing the rat and hamster response to…”
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TNFα and increased chemokine expression in rat lung after particle exposure by Driscoll, Kevin E., Hassenbein, Diana G., Carter, Janet M., Kunkel, Steven L., Quinlan, Timothy R., Mossman, Brooke T.

“…Macrophage inflammatory protein 2 (MIP-2) and CINC (Cytokine-Induced-Neutrophil-Chemoattractant) are members of the chemokine family of inflammatory and…”
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Establishment of Immortalized Alveolar Type II Epithelial Cell Lines from Adult Rats by K. E. Driscoll, Carter, J. M., Iype, P. T., Kumari, H. L., L. L. Crosby, M. J. Aardema, R. J. Isfort, D. Cody, M. H. Chestnut, J. L. Burns, R. A. Le Boeuf

“…We developed methodology to isolate and culture rat alveolar Type II cells under conditions that preserved their proliferative capacity, and applied…”
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Pulmonary response to silica or titanium dioxide: inflammatory cells, alveolar macrophage-derived cytokines, and histopathology by Driscoll, K E, Lindenschmidt, R C, Maurer, J K, Higgins, J M, Ridder, G

“…We investigated the effects of silica (SiO2) and titanium dioxide (TiO2) on the pulmonary recruitment of inflammatory cells and the ability of alveolar…”
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Cytokine and growth factor release by alveolar macrophages: potential biomarkers of pulmonary toxicity by Driscoll, K E, Maurer, J K

“…Studies comparing pulmonary responses to crystalline silica (SiO2) and titanium dioxide (0.3 microns diameter, TiO2-F) demonstrated a positive correlation…”
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Refractory ceramic fibers activate alveolar macrophage eicosanoid and cytokine release by Leikauf, G D, Fink, S P, Miller, M L, Lockey, J E, Driscoll, K E

“…Refractory ceramic fiber has been developed for industrial processes requiring materials with high thermal and mechanical stability. To evaluate the biological…”
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Ozone inhalation stimulates expression of a neutrophil chemotactic protein, macrophage inflammatory protein 2 by Driscoll, K E, Simpson, L, Carter, J, Hassenbein, D, Leikauf, G D

“…Short-term exposure of humans and animals to ozone results in increased lung neutrophils; however, the mechanisms underlying this response are not completely…”
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Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis by Driscoll, K E, Maurer, J K, Poynter, J, Higgins, J, Asquith, T, Miller, N S

“…Rats were exposed to saline or cadmium chloride (CdCl2) at 25, 100, or 400 micrograms/kg body weight by intratracheal instillation. At 3, 7, 14, and 28 days…”
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Pulmonary response to inhaled silica or titanium dioxide by Driscoll, K E, Lindenschmidt, R C, Maurer, J K, Perkins, L, Perkins, M, Higgins, J

“…The pulmonary response to mineral dust inhalation was investigated by characterizing markers of lung injury and inflammation, macrophage activation, dust…”
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