Search Results - "Driscoll, David R."

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer by Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, T R Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J, Klimstra, David S, Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P

“…mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused…”
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activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis by Rajurkar, Mihir, De Jesus-Monge, Wilfredo E, Driscoll, David R, Appleman, Victoria A, Huang, He, Cotton, Jennifer L, Klimstra, David S, Zhu, Lihua J, Simin, Karl, Xu, Lan, McMahon, Andrew P, Lewis, Brian C, Mao, Junhao

“…Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignancies, is thought to be initiated by KRAS activation. Here we find that…”
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X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor by Rivera, Miguel N, Kim, Woo Jae, Wells, Julie, Driscoll, David R, Brannigan, Brian W, Han, Moonjoo, Kim, James C, Feinberg, Andrew P, Gerald, William L, Vargas, Sara O, Chin, Lynda, Iafrate, A. John, Bell, Daphne W, Haber, Daniel A

“…Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for…”
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Irreversible Inhibitors of the EGF Receptor May Circumvent Acquired Resistance to Gefitinib by Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.

“…Non-small cell lung cancers (NSCLCs) with activating mutations in the kinase domain of the epidermal growth factor receptor (EGFR) demonstrate dramatic, but…”
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Activated Wnt Signaling in Stroma Contributes to Development of Pancreatic Mucinous Cystic Neoplasms by Sano, Makoto, Driscoll, David R, De Jesus-Monge, Wilfredo E, Klimstra, David S, Lewis, Brian C

“…Background & Aims Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to…”
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Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas by KWAK, Eunice L, JANKOWSKI, Janusz, MUIR, Beth, SETTLEMAN, Jeff, FUCHS, Charles S, KULKE, Matthew H, RYAN, David P, CLARK, Jeff W, SGROI, Dennis C, HABER, Daniel A, BELL, Daphne W, THAYER, Sarah P, LAUWERS, Gregory Y, BRANNIGAN, Brian W, HARRIS, Patricia L, OKIMOTO, Ross A, HASERLAT, Sara M, DRISCOLL, David R, FERRY, David

“…Purpose: Specific activating mutations within the epidermal growth factor receptor ( EGFR ) identify a subset of non–small cell lung cancers with dramatic…”
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The p53R172H mutant does not enhance hepatocellular carcinoma development and progression by Ahronian, Leanne G, Driscoll, David R, Klimstra, David S, Lewis, Brian C

“…Hepatocellular carcinoma is a highly deadly malignancy, accounting for approximately 800,000 deaths worldwide every year. Mutation of the p53 tumor suppressor…”
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Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61 by Sano, Makoto, Driscoll, David R, DeJesus-Monge, Wilfredo E, Quattrochi, Brian, Appleman, Victoria A, Ou, Jianhong, Zhu, Lihua Julie, Yoshida, Nao, Yamazaki, Shintaro, Takayama, Tadatoshi, Sugitani, Masahiko, Nemoto, Norimichi, Klimstra, David S, Lewis, Brian C

“…Abstract Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation…”
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MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression by Quattrochi, Brian, Gulvady, Anushree, Driscoll, David R, Sano, Makoto, Klimstra, David S, Turner, Christopher E, Lewis, Brian C

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterized by resistance to currently employed chemotherapeutic approaches. Members of the…”
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Functionally defective germline variants of sialic acid acetylesterase in autoimmunity by Pillai, Shiv, Surolia, Ira, Pirnie, Stephan P, Chellappa, Vasant, Taylor, Kendra N, Cariappa, Annaiah, Moya, Jesse, Liu, Haoyuan, Bell, Daphne W, Driscoll, David R, Diederichs, Sven, Haider, Khaleda, Netravali, Ilka, Le, Sheila, Elia, Roberto, Dow, Ethan, Lee, Annette, Freudenberg, Jan, De Jager, Philip L, Chretien, Yves, Varki, Ajit, MacDonald, Marcy E, Gillis, Tammy, Behrens, Timothy W, Bloch, Donald, Collier, Deborah, Korzenik, Joshua, Podolsky, Daniel K, Hafler, David, Murali, Mandakolathur, Sands, Bruce, Stone, John H, Gregersen, Peter K

“…Sialic acid acetylesterase (SIAE) is an enzyme that negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of…”
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Abstract A08: Activation of Wnt/β-catenin in acinar cells accelerates Kras-induced PDAC, while activation of Wnt signaling pathways in stroma induces mucinous cystic neoplasm by Sano, Makoto, Driscoll, David R., DeJesus-Monge, Wilfredo E., Klimstra, David S., Lewis, Brian C.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) commonly develops following activating mutations in the KRAS oncogene. Activation of the Wnt signaling pathway…”
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The p53.sup.R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression by Ahronian, Leanne G, Driscoll, David R, Klimstra, David S, Lewis, Brian C

“…Hepatocellular carcinoma is a highly deadly malignancy, accounting for approximately 800,000 deaths worldwide every year. Mutation of the p53 tumor suppressor…”
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Abstract B25: Activation of Wnt/β-catenin signaling pathway enhances pancreatic cancer development and the malignant potential via up-regulation of Cyr61/CCN1 by Sano, Makoto, Driscoll, David R., DeJesus-Monge, Wilfredo E., Quattrochi, Brian, Appleman, Victoria A., Ou, Jianhong, Zhu, Lihua Julie, Yoshida, Nao, Yamazaki, Shintaro, Takayama, Tadatoshi, Sugitani, Masahiko, Nemoto, Norimichi, Klimstra, David S., Lewis, Brian C.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation…”
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Abstract 2742: Activation of Wnt/β-catenin signaling accelerates progression of Kras-induced pancreatic cancer by Sano, Makoto, Driscoll, David R., DeJesus-Monge, Wilfredo E., Klimstra, David S., Lewis, Brian C.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation…”
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Activation of WNT/[beta]-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61 by Sano, Makoto, Driscoll, David R, Dejesus-Monge, Wilfredo E, Quattrochi, Brian, Appleman, Victoria A, Ou, Jianhong, Zhu, Lihua Julie, Yoshida, Nao, Yamazaki, Shintaro, Takayama, Tadatoshi, Sugitani, Masahiko, Nemoto, Norimichi, Klimstra, David S, Lewis, Brian C

“…Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation of WNT…”
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The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis by Rajurkar, Mihir, De Jesus-Monge, Wilfredo E., Driscoll, David R., Appleman, Victoria A., Huang, He, Cotton, Jennifer L., Klimstra, David S., Zhu, Lihua J., Simin, Karl, Xu, Lan, McMahon, Andrew P., Lewis, Brian C., Mao, Junhao

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Extension of β-chloroenals to ethyl 5-chloro-2,4-pentadienoates using Wadsworth–Emmons reactions: subsequent conversions to 5-aryl-5-chloro-2,4-pentadienoic acids and 5-aryl-2-penten-4-ynoic acids by Clough, Stuart C., Gupton, John T., Driscoll, David R., Griffin, Katherine A., Hewitt, Alisa M., Hudson, Matthew S., Ligali, S. Adepeju, Mulcahy, Seann P., Roberts, Matthew N., Miller, Robert B., Belachew, Tsegahiwot T., Kamenova, Ivanka D., Kanters, René P.F., Norwood, Bradley K.

“…Convenient routes from ( Z)-3-aryl-3-chloroenals to (2 E,4 Z)-5-aryl-5-chloro-2,4-pentadienoates and (2 E)-5-aryl-2-penten-4-ynoates are described. The…”
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