Factors associated with thrombosis in pediatric patients with systemic lupus erythematosus

Objective The risk of thrombosis is increased in patients with systemic lupus erythematosus (SLE). Few studies have assessed factors associated with thrombosis within the pediatric SLE (pSLE) population. We sought to better characterize these associated factors in pSLE patients using the Childhood A...

Full description

Saved in:

Bibliographic Details
Published in:	Lupus Vol. 25; no. 7; pp. 749 - 753
Main Authors:	Driest, K D, Sturm, M S, O’Brien, S H, Spencer, C H, Stanek, J R, Ardoin, S P
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-06-2016 Sage Publications Ltd
Subjects:	Adolescent Antibodies, Antiphospholipid - blood Antiphospholipid Syndrome - epidemiology Antiphospholipid Syndrome - immunology Arthritis Autoimmune diseases Avascular necrosis Child Child, Preschool Children Female Health risk assessment Humans Infant Logistic Models Lupus Lupus Erythematosus, Systemic - complications Male Multivariate Analysis Pediatrics Prospective Studies Registries Retrospective Studies Risk Factors Systemic lupus erythematosus Thrombosis Thrombosis - epidemiology Thrombosis - immunology United States Vasculitis Vasculitis - epidemiology Vasculitis - immunology Young Adult antiphospholipid syndrome Systemic lupus erythematosus thrombosis avascular necrosis vasculitis pediatric
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective The risk of thrombosis is increased in patients with systemic lupus erythematosus (SLE). Few studies have assessed factors associated with thrombosis within the pediatric SLE (pSLE) population. We sought to better characterize these associated factors in pSLE patients using the Childhood Arthritis & Rheumatology Research Alliance (CARRA) registry. Methods Within the CARRA registry, patients with a history of thrombosis were compared to those without. Univariate logistic regression was used to calculate odds ratios. A multivariable logistic regression model was conducted that included variables from the univariate analysis that had a p value < 0.10 and other variables identified as clinically significant from published literature. Results Among the 979 pSLE patients in the CARRA registry, 24 (2.5%) patients had a history of arterial thrombosis and 35 (3.6%) of venous thrombosis. In the univariate analysis, the odds ratio of having a thrombotic event were found to be significantly higher in patients with a history of vasculitis, avascular necrosis (AVN), or antiphospholipid antibody (aPL). Similar results were found for vasculitis, AVN, and aPL in the multivariable analysis. Conclusion Our study of pSLE patients suggests that vasculitis, positive APL, and AVN are associated with thrombotic events in this population.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203316638164