Search Results - "Drier, Yotam"

Pathway-based personalized analysis of cancer by Drier, Yotam, Sheffer, Michal, Domany, Eytan

“…We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined,…”
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SARS-CoV-2 infection perturbs enhancer mediated transcriptional regulation of key pathways by Yedidya, Yahel, Davis, Daniel, Drier, Yotam

“…Despite extensive studies on the effects of SARS-CoV-2 infection, there is still a lack of understanding of the downstream epigenetic and regulatory…”
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Insulator dysfunction and oncogene activation in IDH mutant gliomas by Flavahan, William A., Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Venteicher, Andrew S., Stemmer-Rachamimov, Anat O., Suvà, Mario L., Bernstein, Bradley E.

“…An epigenetic mechanism in which gain-of-function IDH mutations promote gliomagenesis by disrupting chromosomal topology is presented, with IDH mutations…”
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Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer by Shah, Neel, Wang, Ping, Wongvipat, John, Karthaus, Wouter R, Abida, Wassim, Armenia, Joshua, Rockowitz, Shira, Drier, Yotam, Bernstein, Bradley E, Long, Henry W, Freedman, Matthew L, Arora, Vivek K, Zheng, Deyou, Sawyers, Charles L

“…In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid…”
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Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs by Flavahan, William A., Drier, Yotam, Johnstone, Sarah E., Hemming, Matthew L., Tarjan, Daniel R., Hegazi, Esmat, Shareef, Sarah J., Javed, Nauman M., Raut, Chandrajit P., Eschle, Benjamin K., Gokhale, Prafulla C., Hornick, Jason L., Sicinska, Ewa T., Demetri, George D., Bernstein, Bradley E.

“…Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood 1 – 3 . A subset of gastrointestinal…”
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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer by Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

“…Evolved resistance to tyrosine kinase inhibitor (TKI)-targeted therapies remains a major clinical challenge. In epidermal growth factor receptor ( EGFR )…”
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SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation by Wang, Xiaofeng, Lee, Ryan S, Alver, Burak H, Haswell, Jeffrey R, Wang, Su, Mieczkowski, Jakub, Drier, Yotam, Gillespie, Shawn M, Archer, Tenley C, Wu, Jennifer N, Tzvetkov, Evgeni P, Troisi, Emma C, Pomeroy, Scott L, Biegel, Jaclyn A, Tolstorukov, Michael Y, Bernstein, Bradley E, Park, Peter J, Roberts, Charles W M

“…Charles Roberts, Peter Park, Bradley Bernstein and colleagues examine the consequences of SMARCB1 loss on enhancer landscapes in human rhabdoid tumors. They…”
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An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma by Drier, Yotam, Cotton, Matthew J, Williamson, Kaylyn E, Gillespie, Shawn M, Ryan, Russell J H, Kluk, Michael J, Carey, Christopher D, Rodig, Scott J, Sholl, Lynette M, Afrogheh, Amir H, Faquin, William C, Queimado, Lurdes, Qi, Jun, Wick, Michael J, El-Naggar, Adel K, Bradner, James E, Moskaluk, Christopher A, Aster, Jon C, Knoechel, Birgit, Bernstein, Bradley E

“…Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of MYB in adenoid cystic carcinoma (ACC)…”
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Genetic interrogation of circulating multiple myeloma cells at single-cell resolution by Lohr, Jens G, Kim, Sora, Gould, Joshua, Knoechel, Birgit, Drier, Yotam, Cotton, Matthew J, Gray, Daniel, Birrer, Nicole, Wong, Bang, Ha, Gavin, Zhang, Cheng-Zhong, Guo, Guangwu, Meyerson, Matthew, Yee, Andrew J, Boehm, Jesse S, Raje, Noopur, Golub, Todd R

“…Multiple myeloma (MM) remains an incurable disease, with a treatment-refractory state eventually developing in all patients. Constant clonal evolution and…”
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Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes? by Drier, Yotam, Domany, Eytan

“…The fact that there is very little if any overlap between the genes of different prognostic signatures for early-discovery breast cancer is well documented…”
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Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma by Ryan, Russell J H, Drier, Yotam, Whitton, Holly, Cotton, M Joel, Kaur, Jasleen, Issner, Robbyn, Gillespie, Shawn, Epstein, Charles B, Nardi, Valentina, Sohani, Aliyah R, Hochberg, Ephraim P, Bernstein, Bradley E

“…B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel…”
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Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis by Kato, Shinichiro, Weng, Qing Yu, Insco, Megan L, Chen, Kevin Y, Muralidhar, Sathya, Pozniak, Joanna, Diaz, Joey Mark S, Drier, Yotam, Nguyen, Nhu, Lo, Jennifer A, van Rooijen, Ellen, Kemeny, Lajos V, Zhan, Yao, Feng, Yang, Silkworth, Whitney, Powell, C Thomas, Liau, Brian B, Xiong, Yan, Jin, Jian, Newton-Bishop, Julia, Zon, Leonard I, Bernstein, Bradley E, Fisher, David E

“…Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic…”
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Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus by Handal, Tayma, Juster, Sarah, Abu Diab, Manar, Yanovsky-Dagan, Shira, Zahdeh, Fouad, Aviel, Uria, Sarel-Gallily, Roni, Michael, Shir, Bnaya, Ester, Sebban, Shulamit, Buganim, Yosef, Drier, Yotam, Mouly, Vincent, Kubicek, Stefan, van den Broek, Walther J. A. A., Wansink, Derick G., Epsztejn-Litman, Silvina, Eiges, Rachel

“…Epigenetic defects caused by hereditary or de novo mutations are implicated in various human diseases. It remains uncertain whether correcting the underlying…”
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WWOX promotes osteosarcoma development via upregulation of Myc by Akkawi, Rania, Hidmi, Osama, Haj-Yahia, Ameen, Monin, Jonathon, Diment, Judith, Drier, Yotam, Stein, Gary S., Aqeilan, Rami I.

“…Osteosarcoma is an aggressive bone tumor that primarily affects children and adolescents. This malignancy is highly aggressive, associated with poor clinical…”
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Correction: WWOX promotes osteosarcoma development via upregulation of Myc by Akkawi, Rania, Hidmi, Osama, Haj-Yahia, Ameen, Monin, Jonathon, Diment, Judith, Drier, Yotam, Stein, Gary S., Aqeilan, Rami I.

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Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals by Zwang, Yaara, Sas-Chen, Aldema, Drier, Yotam, Shay, Tal, Avraham, Roi, Lauriola, Mattia, Shema, Efrat, Lidor-Nili, Efrat, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Lu, Yiling, Mills, Gordon B., Rechavi, Gideon, Oren, Moshe, Domany, Eytan, Yarden, Yosef

“…Normal cells require continuous exposure to growth factors in order to cross a restriction point and commit to cell-cycle progression. This can be replaced by…”
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Accurate estimation of pathway activity in single cells for clustering and differential analysis by Davis, Daniel, Wizel, Avishai, Drier, Yotam

“…Inferring which and how biological pathways and gene sets change is a key question in many studies that utilize single-cell RNA sequencing. Typically, these…”
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Accurate estimation of pathway activity in single cells for clustering and differential analysis by Davis, Daniel, Wizel, Avishai, Drier, Yotam

“…Inferring which and how biological pathways and gene sets change is a key question in many studies that utilize single-cell RNA sequencing. Typically, these…”
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Enhancer and superenhancer regulation and its disruption in cancer by Drier, Yotam

“…Enhancers are DNA elements that promote transcription of distal genes and have a key role in regulating gene expression in metazoans. Disruption of proper gene…”
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Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation by Gagliani, Nicola, Vesely, Maria Carolina Amezcua, Iseppon, Andrea, Brockmann, Leonie, Xu, Hao, Palm, Noah W., de Zoete, Marcel R., Licona-Limón, Paula, Paiva, Ricardo S., Ching, Travers, Weaver, Casey, Zi, Xiaoyuan, Pan, Xinghua, Fan, Rong, Garmire, Lana X., Cotton, Matthew J., Drier, Yotam, Bernstein, Bradley, Geginat, Jens, Stockinger, Brigitta, Esplugues, Enric, Huber, Samuel, Flavell, Richard A.

“…Inflammation is a beneficial host response to infection but can contribute to inflammatory disease if unregulated. The T h 17 lineage of T helper (T h ) cells…”
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