Search Results - "Drienovská, Ivana"

Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid by Drienovská, Ivana, Alonso-Cotchico, Lur, Vidossich, Pietro, Lledós, Agustí, Maréchal, Jean-Didier, Roelfes, Gerard

“…The design of artificial metalloenzymes is a challenging, yet ultimately highly rewarding objective because of the potential for accessing new-to-nature…”
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Artificial Metalloproteins for Binding and Stabilization of a Semiquinone Radical by Ségaud, Nathalie, Drienovská, Ivana, Chen, Juan, Browne, Wesley R, Roelfes, Gerard

“…The interaction of a number of first-row transition-metal ions with a 2,2′-bipyridyl alanine (bpyA) unit incorporated into the lactococcal multidrug resistance…”
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Folding Assessment of Incorporation of Noncanonical Amino Acids Facilitates Expansion of Functional‐Group Diversity for Enzyme Engineering by Drienovská, Ivana, Gajdoš, Matúš, Kindler, Alexia, Takhtehchian, Mahsa, Darnhofer, Barbara, Birner‐Gruenberger, Ruth, Dörr, Mark, Bornscheuer, Uwe T., Kourist, Robert

“…Protein design is limited by the diversity of functional groups provided by the canonical protein „building blocks“. Incorporating noncanonical amino acids…”
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Integrated Computational Study of the Cu-Catalyzed Hydration of Alkenes in Water Solvent and into the Context of an Artificial Metallohydratase by Alonso-Cotchico, Lur, Sciortino, Giuseppe, Vidossich, Pietro, Rodríguez-Guerra Pedregal, Jaime, Drienovská, Ivana, Roelfes, Gerard, Lledós, Agusti, Maréchal, Jean-Didier

“…Despite the increasing efforts in the last few years, the identification of efficient catalysts able to perform the enantioselective addition of water to…”
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Artificial, biomimetic and hybrid enzymes: general discussion by Acevedo-Rocha, Carlos, Bakshi, Amulyasai, Bornscheuer, Uwe T, Campopiano, Dominic J, Čivić, Janko, Drienovská, Ivana, Ehinger, Friedrich Johannes, Gomm, Andrew, Góra, Artur, Green, Anthony P, Hanzevacki, Marko, Harvey, Jeremy N, Hilvert, Donald, Huang, Meilan, Jarvis, Amanda G, Kamerlin, Shina Caroline Lynn, Lichtenstein, Bruce R, Luk, Louis Y P, Lutz, Stefan, Marsh, E Neil G, McKenzie, Alexander, Moliner, Vicent, Mulholland, Adrian, Osuna, Sílvia, Pelletier, Joelle N, Raczyńska, Agata, Rao, Aditya Gopalakrishna, Rhys, Guto G, Roelfes, Gerard, Rulíšek, Lubomír, Stockinger, Peter, Szleper, Katarzyna, Thompson, Sean Adeoti, Turner, Nicholas, Van der Kamp, Marc, Xu, Guangcai, Zeymer, Cathleen

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A Structural View on the Stereospecificity of Plant Borneol‐Type Dehydrogenases by Chánique, Andrea M., Dimos, Nicole, Drienovská, Ivana, Calderini, Elia, Pantín, Mónica P., Helmer, Carl P. O., Hofer, Michael, Sieber, Volker, Parra, Loreto P., Loll, Bernhard, Kourist, Robert

“…The development of sustainable processes for the valorization of byproducts and other waste streams remains an ongoing challenge in the field of catalysis…”
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Expanding the enzyme universe with genetically encoded unnatural amino acids by Drienovská, Ivana, Roelfes, Gerard

“…The emergence of robust methods to expand the genetic code allows incorporation of non-canonical amino acids into the polypeptide chain of proteins, thus…”
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A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue by Drienovská, Ivana, Mayer, Clemens, Dulson, Christopher, Roelfes, Gerard

“…Creating designer enzymes with the ability to catalyse abiological transformations is a formidable challenge. Efforts toward this goal typically consider only…”
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Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis by Brouwer, Bart, Della-Felice, Franco, Illies, Jan Hendrik, Iglesias-Moncayo, Emilia, Roelfes, Gerard, Drienovská, Ivana

“…Biocatalysis has become an important component of modern organic chemistry, presenting an efficient and environmentally friendly approach to synthetic…”
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Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel–Crafts Alkylase by Leveson-Gower, Reuben B, Zhou, Zhi, Drienovská, Ivana, Roelfes, Gerard

“…The construction and engineering of artificial enzymes consisting of abiological catalytic moieties incorporated into protein scaffolds is a promising strategy…”
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Design of Artificial Enzymes: Insights into Protein Scaffolds by Hanreich, Stefanie, Bonandi, Elisa, Drienovská, Ivana

“…The design of artificial enzymes has emerged as a promising tool for the generation of potent biocatalysts able to promote new‐to‐nature reactions with…”
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Non-canonical amino acids as a tool for the thermal stabilization of enzymes by Lugtenburg, Tim, Gran-Scheuch, Alejandro, Drienovská, Ivana

“…Abstract Biocatalysis has become a powerful alternative for green chemistry. Expanding the range of amino acids used in protein biosynthesis can improve…”
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Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids by Drienovská, Ivana, Rioz-Martínez, Ana, Draksharapu, Apparao, Roelfes, Gerard

“…Artificial metalloenzymes have emerged as an attractive new approach to enantioselective catalysis. Herein, we introduce a novel strategy for preparation of…”
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Expanding the Genetic Code: Incorporation of Functional Secondary Amines via Stop Codon Suppression by Gran‐Scheuch, Alejandro, Bonandi, Elisa, Drienovská, Ivana

“…Enzymes are attractive catalysts for chemical industries, and their use has become a mature alternative to conventional chemical methods. However, biocatalytic…”
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A Hydroxyquinoline‐Based Unnatural Amino Acid for the Design of Novel Artificial Metalloenzymes by Drienovská, Ivana, Scheele, Remkes A., Gutiérrez de Souza, Cora, Roelfes, Gerard

“…We have examined the potential of the noncanonical amino acid (8‐hydroxyquinolin‐3‐yl)alanine (HQAla) for the design of artificial metalloenzymes. HQAla, a…”
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Designing Michaelases: exploration of novel protein scaffolds for iminium biocatalysis by Gran-Scheuch, Alejandro, Hanreich, Stefanie, Keizer, Iris, W Harteveld, Jaap, Ruijter, Eelco, Drienovská, Ivana

“…Biocatalysis is becoming a powerful and sustainable alternative for asymmetric catalysis. However, enzymes are often restricted to metabolic and less complex…”
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Molecular cloning and functional characterization of a two highly stereoselective borneol dehydrogenases from Salvia officinalis L by Drienovská, Ivana, Kolanović, Dajana, Chánique, Andrea, Sieber, Volker, Hofer, Michael, Kourist, Robert

“…Enzymes for selective terpene functionalization are of particular importance for industrial applications. Pure enantiomers of borneol and isoborneol are…”
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Simple Plug‐In Synthetic Step for the Synthesis of (−)‐Camphor from Renewable Starting Materials by Calderini, Elia, Drienovská, Ivana, Myrtollari, Kamela, Pressnig, Michaela, Sieber, Volker, Schwab, Helmut, Hofer, Michael, Kourist, Robert

“…Racemic camphor and isoborneol are readily available as industrial side products, whereas (1R)‐camphor is available from natural sources. Optically pure…”
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Artificial Metalloenzymes for Asymmetric Catalysis by Creation of Novel Active Sites in Protein and DNA Scaffolds by Drienovská, Ivana, Roelfes, Gerard

“…Artificial metalloenzymes have emerged as a promising new approach to asymmetric catalysis. In our group, we are exploring novel artificial metalloenzyme…”
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Front Cover: Expanding the Genetic Code: Incorporation of Functional Secondary Amines via Stop Codon Suppression (ChemCatChem 1/2024) by Gran‐Scheuch, Alejandro, Bonandi, Elisa, Drienovská, Ivana

“…The Front Cover illustrates the design of artificial enzymes incorporating secondary amines‐harbouring non‐canonical amino acids (ncAAs). The amino acids,…”
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