Search Results - "Dreyfuss, M"

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites by Fujisaka, Shiho, Avila-Pacheco, Julian, Soto, Marion, Kostic, Aleksandar, Dreyfuss, Jonathan M., Pan, Hui, Ussar, Siegfried, Altindis, Emrah, Li, Ning, Bry, Lynn, Clish, Clary B., Kahn, C. Ronald

“…Diet, genetics, and the gut microbiome are determinants of metabolic status, in part through production of metabolites by the gut microbiota. To understand the…”
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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes by Batista, Thiago M., Jayavelu, Ashok Kumar, Wewer Albrechtsen, Nicolai J., Iovino, Salvatore, Lebastchi, Jasmin, Pan, Hui, Dreyfuss, Jonathan M., Krook, Anna, Zierath, Juleen R., Mann, Matthias, Kahn, C. Ronald

“…Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding and predicting disease development. To what extent this reflects…”
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FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy by O'Neill, Brian T, Bhardwaj, Gourav, Penniman, Christie M, Krumpoch, Megan T, Suarez Beltran, Pablo A, Klaus, Katherine, Poro, Kennedy, Li, Mengyao, Pan, Hui, Dreyfuss, Jonathan M, Nair, K Sreekumaran, Kahn, C Ronald

“…Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO…”
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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression by Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O’Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald

“…Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate…”
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Antibiotic effects on gut microbiota and metabolism are host dependent by Fujisaka, Shiho, Ussar, Siegfried, Clish, Clary, Devkota, Suzanne, Dreyfuss, Jonathan M, Sakaguchi, Masaji, Soto, Marion, Konishi, Masahiro, Softic, Samir, Altindis, Emrah, Li, Ning, Gerber, Georg, Bry, Lynn, Kahn, C Ronald

“…Interactions of diet, gut microbiota, and host genetics play important roles in the development of obesity and insulin resistance. Here, we have investigated…”
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SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms by Osataphan, Soravis, Macchi, Chiara, Singhal, Garima, Chimene-Weiss, Jeremy, Sales, Vicencia, Kozuka, Chisayo, Dreyfuss, Jonathan M, Pan, Hui, Tangcharoenpaisan, Yanin, Morningstar, Jordan, Gerszten, Robert, Patti, Mary-Elizabeth

“…Pharmacologic inhibition of the renal sodium/glucose cotransporter-2 induces glycosuria and reduces glycemia. Given that SGLT2 inhibitors (SGLT2i) reduce…”
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Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy by Gordin, Daniel, Shah, Hetal, Shinjo, Takanori, St-Louis, Ronald, Qi, Weier, Park, Kyoungmin, Paniagua, Samantha M, Pober, David M, Wu, I-Hsien, Bahnam, Vanessa, Brissett, Megan J, Tinsley, Liane J, Dreyfuss, Jonathan M, Pan, Hui, Dong, Yutong, Niewczas, Monika A, Amenta, Peter, Sadowski, Thorsten, Kannt, Aimo, Keenan, Hillary A, King, George L

“…Elevated glycolytic enzymes in renal glomeruli correlated with preservation of renal function in the Medalist Study, individuals with ≥50 years of type 1…”
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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis by Nagao, Hirofumi, Jayavelu, Ashok Kumar, Cai, Weikang, Pan, Hui, Dreyfuss, Jonathan M., Batista, Thiago M., Brandão, Bruna B., Mann, Matthias, Kahn, C. Ronald

“…Insulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic and mitogenic actions. Here, using receptors with either short…”
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Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence by Steinbaugh, Michael J, Narasimhan, Sri Devi, Robida-Stubbs, Stacey, Moronetti Mazzeo, Lorenza E, Dreyfuss, Jonathan M, Hourihan, John M, Raghavan, Prashant, Operaña, Theresa N, Esmaillie, Reza, Blackwell, T Keith

“…In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also increases fat accumulation and alters lipid metabolism, raising…”
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The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response by Lavoie, Sydney, Conway, Kara L, Lassen, Kara G, Jijon, Humberto B, Pan, Hui, Chun, Eunyoung, Michaud, Monia, Lang, Jessica K, Gallini Comeau, Carey Ann, Dreyfuss, Jonathan M, Glickman, Jonathan N, Vlamakis, Hera, Ananthakrishnan, Ashwin, Kostic, Aleksander, Garrett, Wendy S, Xavier, Ramnik J

“…Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD…”
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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling by Nagao, Hirofumi, Cai, Weikang, Brandão, Bruna B, Wewer Albrechtsen, Nicolai J, Steger, Martin, Gattu, Arijeet K, Pan, Hui, Dreyfuss, Jonathan M, Wunderlich, F Thomas, Mann, Matthias, Kahn, C Ronald

“…Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR…”
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Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets by Basile, Giorgio, Kahraman, Sevim, Dirice, Ercument, Pan, Hui, Dreyfuss, Jonathan M, Kulkarni, Rohit N

“…Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human…”
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High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control by Dreyfuss, Jonathan M., Yuchi, Yixing, Dong, Xuehong, Efthymiou, Vissarion, Pan, Hui, Simonson, Donald C., Vernon, Ashley, Halperin, Florencia, Aryal, Pratik, Konkar, Anish, Sebastian, Yinong, Higgs, Brandon W., Grimsby, Joseph, Rondinone, Cristina M., Kasif, Simon, Kahn, Barbara B., Foster, Kathleen, Seeley, Randy, Goldfine, Allison, Djordjilović, Vera, Patti, Mary Elizabeth

“…To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of…”
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Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM by Dreyfuss, Jonathan M, Zucker, Jeremy D, Hood, Heather M, Ocasio, Linda R, Sachs, Matthew S, Galagan, James E

“…The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and…”
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Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism by Lerin, Carles, Goldfine, Allison B, Boes, Tanner, Liu, Manway, Kasif, Simon, Dreyfuss, Jonathan M, De Sousa-Coelho, Ana Luisa, Daher, Grace, Manoli, Irini, Sysol, Justin R, Isganaitis, Elvira, Jessen, Niels, Goodyear, Laurie J, Beebe, Kirk, Gall, Walt, Venditti, Charles P, Patti, Mary-Elizabeth

“…Abstract Objective Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively…”
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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance by Shirakawa, Jun, Togashi, Yu, Basile, Giorgio, Okuyama, Tomoko, Inoue, Ryota, Fernandez, Megan, Kyohara, Mayu, De Jesus, Dario F., Goto, Nozomi, Zhang, Wei, Tsuno, Takahiro, Kin, Tatsuya, Pan, Hui, Dreyfuss, Jonathan M., Shapiro, A.M. James, Yi, Peng, Terauchi, Yasuo, Kulkarni, Rohit N.

“…Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly…”
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Developmental and functional heterogeneity of white adipocytes within a single fat depot by Lee, Kevin Y, Luong, Quyen, Sharma, Rita, Dreyfuss, Jonathan M, Ussar, Siegfried, Kahn, C Ronald

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FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation by Allu, Prasanna K.R., Cardamone, Maria Dafne, Gomes, Antonio S., Dall'agnese, Alessandra, Cederquist, Carly, Pan, Hui, Dreyfuss, Jonathan M., Enerbäck, Sven, Kahn, C. Ronald

“…Insulin acts on the liver via changes in gene expression to maintain glucose and lipid homeostasis. This study aimed to the Forkhead box protein K1 (FOXK1)…”
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Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors by Bhardwaj, Gourav, Penniman, Christie M, Klaus, Katherine, Weatherford, Eric T, Pan, Hui, Dreyfuss, Jonathan M, Nair, K Sreekumaran, Kahn, C Ronald, O'Neill, Brian T

“…Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which…”
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Evaluation of a machine learning tool for the early identification of patients with undiagnosed psoriatic arthritis – A retrospective population-based study by Shapiro, J., Getz, B., Cohen, S.B., Jenudi, Y., Underberger, D., Dreyfuss, M., Ber, T.I., Steinberg-Koch, S., Ben-Tov, A., Shoenfeld, Y., Shovman, O.

“…Psoriatic arthritis (PsA), an immune-mediated chronic inflammatory skin and joint disease, affects approximately 0.27% of the adult population, and 20% of…”
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