Search Results - "Dreyer, Robert N"

Electrospray interface for liquid chromatographs and mass spectrometers by Whitehouse, Craig M, Dreyer, Robert N, Yamashita, Masamichi, Fenn, John B

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Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug by PIZZORNO, G, MINI, E, BERTINO, J. R, CORONNELLO, M, MCGUIRE, J. J, MOROSON, B. A, CASHMORE, A. R, DREYER, R. N, LIN, J. T, MAZZEI, T, PERITI, P

“…Two methotrexate-resistant sublines, CCRF-CEM R3/7 and CCRF-CEM R30/6, were selected from the human leukemia T-lymphoblast cell line, CCRF-CEM, after repeated…”
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Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics by LIN, J. T, CASHMORE, A. R, BAKER, M, DREYER, R. N, ERNSTOFF, M, MARSH, J. C, BERTINO, J. R, WHITFIELD, L. R, DELAP, R, GRILLO-LOPEZ, A

“…Twenty-two patients with advanced solid tumors were treated with a quinazoline folate antagonist, trimetrexate, to determine the toxicity spectrum, the maximal…”
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Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's .beta.-amyloid precursor protein by Heald, Sarah L, Tilton, Robert F, Hammond, Lisa J, Lee, Alice, Bayney, Richard M, Kamarck, Michael E, Ramabhadran, Triprayar V, Dreyer, Robert N, Davis, Gary

“…Certain precursor proteins (APP751 and APP770) of the amyloid beta-protein (AP) present in Alzheimer's disease contain a Kunitz-type serine protease inhibitor…”
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Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs by Weir, E C, Cashmore, A R, Dreyer, R N, Graham, M L, Hsiao, N, Moroson, B A, Sawicki, W L, Bertino, J R

“…The pharmacology of trimetrexate (JB-11, NSC 249008, 2,4-diamino-5-methyl-5-[(3,4,5-trimethoxyanilino)methyl]quinazoline), an antitumor agent effective against…”
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Metabolism of S-adenosylhomocysteine and S-tubercidinylhomocysteine in neuroblastoma cells by Crooks, Peter A, Dreyer, Robert N, Coward, James K

“…The metabolism of the methylase product inhibitor S-adenosylhomocysteine and its 7-deaza analogue S-tubercidinylhomocysteine has been studied in cultured N-18…”
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Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation by Dreyer, Robert N., Bausch, Kathryn M., Fracasso, Paul, Hammond, Lisa J., Wunderlich, David, Wirak, Dana O., Davis, Gary, Brini, Carla M., Buckholz, Thomas M., König, Gerhard, Kamarck, Michael E., Tamburini, Paul P.

“…A major pre‐β‐amyloid protein695 (APP695) processing activity from Alzheimer's disease brain extracts was identified and found to be indistinguishable from the…”
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A fluorometric assay for HIV-protease activity using high-performance liquid chromatography by Tamburini, P P, Dreyer, R N, Hansen, J, Letsinger, J, Elting, J, Gore-Willse, A, Dally, R, Hanko, R, Osterman, D, Kamarck, M E

“…A rapid sensitive method for the quantification of in vitro HIV-protease activity has been developed on the basis of the endoproteolytic conversion of…”
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Biological/Biomedical Applications of Liquid Chromatography III by Dreyer, Robert N.

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Pyrimidine nucleoside phosphorylase assay by automated high-performance liquid chromatography by Siegel, S A, Woods, K L, Dreyer, R N

“…A new assay for pyrimidine nucleoside phosphorylase is reported. This method utilizes an isocratic reversed-phase high-performance liquid chromatographic…”
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Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells by SCANLON, K. J, CASHMORE, A. R, KASHANI-SABET, M, PALLAI, M, DREYER, R. N, MOROSON, B. A, SAKETOS, M

“…Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid…”
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Inhibition of serine metabolism by tetrahydrohomofolate in L1210 mouse leukemia cells by Scanlon, K J, Cashmore, A R, Moroson, B A, Dreyer, R N, Bertino, J R

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Determination of 5-hydroxytryptamine metabolites in isolated perfused rabbit lung by high-performance liquid chromatography by Crooks, P A, Dreyer, R N, Sulens, C H, Gillis, C N, Coward, J K

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