Search Results - "Drerup, Justin M."

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma by Clark, Curtis A, Gupta, Harshita B, Sareddy, Gangadhara, Pandeswara, Srilakshmi, Lao, Shunhua, Yuan, Bin, Drerup, Justin M, Padron, Alvaro, Conejo-Garcia, José, Murthy, Kruthi, Liu, Yang, Turk, Mary Jo, Thedieck, Kathrin, Hurez, Vincent, Li, Rong, Vadlamudi, Ratna, Curiel, Tyler J

“…PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in the…”
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CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade by Drerup, Justin M, Deng, Yilun, Pandeswara, Sri Lakshmi, Padrón, Álvaro S, Reyes, Ryan M, Zhang, Xinyue, Mendez, Jenny, Liu, Aijie, Clark, Curtis A, Chen, Wanjiao, Conejo-Garcia, José R, Hurez, Vincent, Gupta, Harshita, Curiel, Tyler J

“…The IL2 receptor (IL2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Treg) and antitumor T cells. Here we…”
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Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model by Padrón, Álvaro, Hurez, Vincent, Gupta, Harshita B., Clark, Curtis A., Pandeswara, Sri Lakshmi, Yuan, Bin, Svatek, Robert S., Turk, Mary Jo, Drerup, Justin M., Li, Rong, Curiel, Tyler J.

“…Cancer immunotherapy has shown remarkable recent progress. Immune checkpoint blocking antibodies have become the most successful anti-cancer agent class ever…”
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Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum by Torres‐Altoro, Melissa I., Mathur, Brian N., Drerup, Justin M., Thomas, Rachel, Lovinger, David M., O’Callaghan, James P., Bibb, James A.

“…J. Neurochem. (2011) 119, 303–313. The neurological effects of organophosphate (OP) pesticides, commonly used on foods and in households, are an important…”
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Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch by Yuan, Bin, Clark, Curtis A, Wu, Bogang, Yang, Jing, Drerup, Justin M, Li, Tianbao, Jin, Victor X, Hu, Yanfen, Curiel, Tyler J, Li, Rong

“…BackgroundThe non-overlapping functions of the two estrogen receptor subtypes, ERα (Estrogen Receptor α)and ERβ (Estrogen Receptor β), in tumor cells have been…”
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Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35 by Drerup, Justin M, Hayashi, Kanehiro, Cui, Huxing, Mettlach, Gabriel L, Long, Michael A, Marvin, Marian, Sun, Xiankai, Goldberg, Matthew S, Lutter, Michael, Bibb, James A

“…Background Attention-deficit/hyperactivity disorder (ADHD) may result from delayed establishment of corticolimbic circuitry or perturbed dopamine (DA)…”
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Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment by Liu, Yang, Pandeswara, Srilakshmi, Dao, Vinh, Padrón, Álvaro, Drerup, Justin M, Lao, Shunhua, Liu, Aijie, Hurez, Vincent, Curiel, Tyler J

“…mTOR drives tumor growth but also supports T-cell function, rendering the applications of mTOR inhibitors complex especially in T-cell malignancies. Here, we…”
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Immunotherapy for Ovarian Cancer by Drerup, Justin M., Liu, Yang, Padron, Alvaro S., Murthy, Kruthi, Hurez, Vincent, Zhang, Bin, Curiel, Tyler J.

“…Opinion statement All work referenced herein relates to treatment of epithelial ovarian carcinomas, as their treatment differs from ovarian germ cell cancers…”
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CD122-selective IL-2 complexes reduce immunosuppression, promote Treg fragility, and sensitize tumor response to PD-L1 blockade by Drerup, Justin M., Deng, Yilun, Pandeswara, Sri Lakshmi, Padrón, Álvaro S., Reyes, Ryan M., Zhang, Xinyue, Mendez, Jenny, Liu, Aijie, Clark, Curtis A., Chen, Wanjiao, Conejo-Garcia, José R., Hurez, Vincent, Gupta, Harshita, Curiel, Tyler J.

“…The IL-2 receptor (IL-2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Tregs) and anti-tumor T cells. Here…”
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Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8+ T cell polyfunctionality for durable ovarian cancer immunotherapy by Drerup, Justin M., Pandeswara, Sri Lakshmi, Liu, Aijie, Clark, Curtis A., Padron, Alvaro S., Chen, Wanjiao, Hurez, Vincent, Curiel, Tyler J.

“…Abstract The IL-2 receptor (IL-2R) is an attractive target for cancer immunotherapy as it controls both immune-suppressive regulatory T cells (Tregs) and…”
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