Search Results - "Dremel, E"
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Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off
Published in eLife (22-10-2019)“…Herpes simplex virus-1 (HSV-1) replicates within the nucleus coopting the host's RNA Polymerase II (Pol II) machinery for production of viral mRNAs culminating…”
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Journal Article -
2
Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes
Published in PLoS pathogens (01-01-2017)“…Herpes simplex virus type 1 (HSV-1) infects over half the human population. Much of the infectious cycle occurs in the nucleus of cells where the virus has…”
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Journal Article -
3
Manipulation of RNA polymerase III by Herpes Simplex Virus-1
Published in Nature communications (02-02-2022)“…RNA polymerase III (Pol III) transcribes noncoding RNA, including transfer RNA (tRNA), and is commonly targeted during cancer and viral infection. We find that…”
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Journal Article -
4
Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses
Published in Seminars in cell & developmental biology (15-09-2023)“…During lytic replication, herpesviruses express their genes in a temporal cascade culminating in expression of “late” genes. Two subfamilies of herpesviruses,…”
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Journal Article -
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Genome replication affects transcription factor binding mediating the cascade of herpes simplex virus transcription
Published in Proceedings of the National Academy of Sciences - PNAS (26-02-2019)“…In herpes simplex virus type 1 (HSV-1) infection, the coupling of genome replication and transcription regulation has been known for many years; however, the…”
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Journal Article -
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“Transfer” of power: The intersection of DNA virus infection and tRNA biology
Published in Seminars in cell & developmental biology (15-09-2023)“…Transfer RNAs (tRNAs) are at the heart of the molecular biology central dogma, functioning to decode messenger RNAs into proteins. As obligate intracellular…”
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Journal Article -
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Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection
Published in EMBO reports (12-03-2024)“…To globally profile circRNAs, we employ RNA-Sequencing paired with chimeric junction analysis for alpha-, beta-, and gamma-herpesvirus infection. We find…”
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Journal Article -
8
Arthrodesis of the elbow joint. Indications, surgical technique and clinical results
Published in Der Unfallchirurg (01-04-2010)“…Arthrodesis of the elbow joint (EA) is a rare salvage procedure which is disliked by both surgeons and patients. The aim of this study was to analyze the…”
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Journal Article -
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Hsv-1 Reprogramming of the Host Transcriptional Environment
Published 01-01-2020“…Herpes Simplex Virus-1 (HSV-1) is a ubiquitous pathogen of the oral and genital mucosa. The 152 kilobase double stranded DNA virus employs a coordinated…”
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Dissertation -
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Ellenbogengelenkarthrodese: Indikation, Operationsverfahren und klinische Ergebnisse
Published in Der Unfallchirurg (01-04-2010)“…Zusammenfassung Die Indikation zur Ellenbogengelenkarthrodese (EA) ist selten. Sie gilt als „Rettungsoperation“, führt allerdings zu einer empfindlichen…”
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Journal Article