Search Results - "Drel, Viktor"

Pathophysiology of gadolinium-associated systemic fibrosis by Wagner, Brent, Drel, Viktor, Gorin, Yves

“…Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is…”
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Temporal Telomere and DNA Damage Responses in the Space Radiation Environment by Luxton, Jared J., McKenna, Miles J., Taylor, Lynn E., George, Kerry A., Zwart, Sara R., Crucian, Brian E., Drel, Viktor R., Garrett-Bakelman, Francine E., Mackay, Matthew J., Butler, Daniel, Foox, Jonathan, Grigorev, Kirill, Bezdan, Daniela, Meydan, Cem, Smith, Scott M., Sharma, Kumar, Mason, Christopher E., Bailey, Susan M.

“…Telomeres, repetitive terminal features of chromosomes essential for maintaining genome integrity, shorten with cell division, lifestyle factors and stresses,…”
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PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function by Lupachyk, Sergey, Shevalye, Hanna, Maksimchyk, Yury, Drel, Viktor R., Obrosova, Irina G.

“…This study evaluated the role of poly(ADP-ribose) polymerase (PARP) in systemic oxidative stress and 4-hydoxynonenal adduct accumulation in diabetic peripheral…”
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High-fat diet-induced neuropathy of pre-diabetes and obesity : Effects of healthy diet and aldose reductase inhibition by OBROSOVA, Irina G, ILNYTSKA, Olga, LYZOGUBOV, Valeriy V, PAVLOV, Ivan A, MASHTALIR, Nazar, NADLER, Jerry L, DREL, Viktor R

“…Subjects with dietary obesity and pre-diabetes have an increased risk for developing both nerve conduction slowing and small sensory fiber neuropathy. Animal…”
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Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative–nitrosative stress and p38 MAPK activation by Stavniichuk, Roman, Drel, Viktor R., Shevalye, Hanna, Maksimchyk, Yury, Kuchmerovska, Tamara M., Nadler, Jerry L., Obrosova, Irina G.

“…With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key…”
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Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption by Rajesh, Mohanraj, Mukhopadhyay, Partha, Bátkai, Sándor, Haskó, György, Liaudet, Lucas, Drel, Viktor R, Obrosova, Irina G, Pacher, Pál

“…A nonpsychoactive cannabinoid cannabidiol (CBD) has been shown to exert potent anti-inflammatory and antioxidant effects and has recently been reported to…”
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The leptin-deficient (ob/ob) mouse : A new animal model of peripheral neuropathy of type 2 diabetes and obesity by DREL, Viktor R, MASHTALIR, Nazar, ILNYTSKA, Olga, SHIN, Jeho, FEI LI, LYZOGUBOV, Valeriy V, OBROSOVA, Irina G

“…Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral diabetic neuropathy (PDN) have been extensively explored in…”
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Centrality of bone marrow in the severity of gadolinium‐based contrast‐induced systemic fibrosis by Drel, Viktor R., Tan, Chunyan, Barnes, Jeffrey L., Gorin, Yves, Lee, Doug‐Yoon, Wagner, Brent

“…ABSTRACT Systemic fibrosis can be induced in humans with gadolinium‐based contrast, and cumulative doses correlate with severity. Bone marrow–derived…”
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Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis by Drel, Viktor, Pacher, Pal, Ali, Tayyeba, Shin, Jeho, Julius, Ulrich, El-Remessy, Azza, Obrosova, Irina

“…This study was aimed at evaluating the potent and specific aldose reductase inhibitor fidarestat, on diabetes-associated cataract formation, and retinal…”
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New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-α by Drel, Viktor R, Lupachyk, Sergey, Shevalye, Hanna, Vareniuk, Igor, Xu, Weizheng, Zhang, Jie, Delamere, Nicholas A, Shahidullah, Mohammad, Slusher, Barbara, Obrosova, Irina G

“…This study evaluated poly(ADP-ribose) polymerase (PARP) inhibition as a new therapeutic approach for peripheral diabetic neuropathy using clinically relevant…”
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Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats by Obrosova, Irina G, Drel, Viktor R, Oltman, Christine L, Mashtalir, Nazar, Tibrewala, Jyoti, Groves, John T, Yorek, Mark A

“…Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic complications is emerging. We evaluated the role of peroxynitrite in…”
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Protective effects of polyphenolics in red wine on diabetes associated oxidative/nitrative stress in streptozotocin-diabetic rats by Drel, Viktor R, Sybirna, Nataliya

“…Increased accumulation of NT (3‐nitrotyrosine) and PARylated [poly(ADP‐ribosyl)ated] proteins in the tissues of diabetics are associated with diabetes…”
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Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy by ILNYTSKA, Olga, LYZOGUBOV, Valeriy V, STEVENS, Martin J, DREL, Viktor R, MASHTALIR, Nazar, PACHER, Pal, YOREK, Mark A, OBROSOVA, Irina G

“…Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy Olga Ilnytska 1 , Valeriy V. Lyzogubov 1 , Martin J. Stevens 2 ,…”
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Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy : The relation is revisited by OBROSOVA, Irina G, DREL, Viktor R, PACHER, Pal, ILNYTSKA, Olga, WANG, Zhong Q, STEVENS, Martin J, YOREK, Mark A

“…Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of diabetes complications, is considered a downstream effector of…”
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PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy by Obrosova, Irina G., Xu, Weizheng, Lyzogubov, Valeriy V., Ilnytska, Olga, Mashtalir, Nazar, Vareniuk, Igor, Pavlov, Ivan A., Zhang, Jie, Slusher, Barbara, Drel, Viktor R.

“…Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important role in diabetic complications is emerging. This study evaluated the role of…”
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Poly(ADP-ribose)polymerase inhibition counteracts renal hypertrophy and multiple manifestations of peripheral neuropathy in diabetic Akita mice by Drel, Viktor, Pacher, Pal, Stavniichuk, Roman, Xu, Weizheng, Zhang, Jie, Kuchmerovska, Tamara, Slusher, Barbara, Obrosova, Irina

“…Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of diabetic complications, including nephropathy and peripheral…”
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Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies by Stavniichuk, Roman, Drel, Viktor R., Shevalye, Hanna, Vareniuk, Igor, Stevens, Martin J., Nadler, Jerry L., Obrosova, Irina G.

“…This study evaluated the role of 12/15-lipoxygenase, which converts arachidonic acid to 12( S)- and 15( S)-hydroxyeicosatetraenoic acids, in nitrosative stress…”
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A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice by Drel, Viktor R., Pacher, Pal, Vareniuk, Igor, Pavlov, Ivan, Ilnytska, Olga, Lyzogubov, Valeriy V., Tibrewala, Jyoti, Groves, John T., Obrosova, Irina G.

“…Whereas an important role of free radicals and oxidants in peripheral diabetic neuropathy is well established, the contribution of nitrosative stress and, in…”
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Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells by Drel, Viktor R., Pacher, Pal, Stevens, Martin J., Obrosova, Irina G.

“…Both increased aldose reductase (AR) activity and oxidative/nitrosative stress have been implicated in the pathogenesis of diabetic nephropathy, but the…”
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Poly(ADP-Ribose)Polymerase Inhibition Counteracts Cataract Formation and Early Retinal Changes in Streptozotocin-Diabetic Rats by Drel, Viktor R, Xu, Weizheng, Zhang, Jie, Kador, Peter F, Ali, Tayyeba K, Shin, Jeho, Julius, Ulrich, Slusher, Barbara, El-Remessy, Azza B, Obrosova, Irina G

“…This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. Control and streptozotocin…”
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