Search Results - "Dreier, David A."

Bio-QSARs 2.0: Unlocking a new level of predictive power for machine learning-based ecotoxicity predictions by exploiting chemical and biological information by Zubrod, Jochen P., Galic, Nika, Vaugeois, Maxime, Dreier, David A.

“…Practical, legal, and ethical reasons necessitate the development of methods to replace animal experiments. Computational techniques to acquire information…”
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Physiological variables in machine learning QSARs allow for both cross-chemical and cross-species predictions by Zubrod, Jochen P., Galic, Nika, Vaugeois, Maxime, Dreier, David A.

“…A major challenge in ecological risk assessment is estimating chemical-induced effects across taxa without species-specific testing. Where ecotoxicological…”
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Linking Mitochondrial Dysfunction to Organismal and Population Health in the Context of Environmental Pollutants: Progress and Considerations for Mitochondrial Adverse Outcome Pathways by Dreier, David A., Mello, Danielle F., Meyer, Joel N., Martyniuk, Christopher J.

“…Mitochondria are key targets of many environmental contaminants, because specific chemicals can interact directly with mitochondrial proteins, lipids, and…”
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Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish by Martyniuk, Christopher J., Feswick, April, Munkittrick, Kelly R., Dreier, David A., Denslow, Nancy D.

“…•17alpha-ethinylestradiol (EE2) is one of the most widely studied pharmaceuticals in fish.•Transcriptome studies have revealed mechanisms of action in numerous…”
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Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages by Brooks, Bryan W, van den Berg, Sanne, Dreier, David A, LaLone, Carlie A, Owen, Stewart F, Raimondo, Sandy, Zhang, Xiaowei

“…Translation of environmental science to the practice aims to protect biodiversity and ecosystem services, and our future ability to do so relies on the…”
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Lipidomics reveals multiple stressor effects (temperature × mitochondrial toxicant) in the zebrafish embryo toxicity test by Dreier, David A., Nouri, Mohammad-Zaman, Denslow, Nancy D., Martyniuk, Christopher J.

“…Aquatic organisms are exposed to multiple stressors in the environment, including contaminants and rising temperatures due to climate change. The objective of…”
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Computational in Vitro Toxicology Uncovers Chemical Structures Impairing Mitochondrial Membrane Potential by Dreier, David A, Denslow, Nancy D, Martyniuk, Christopher J

“…Technological advances in molecular biology have enabled high-throughput screening (HTS) of large chemical libraries. These approaches have provided valuable…”
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Developing prototypes of a modernized approach to assess crop protection chemical safety by Currie, Richard A, Abbott, John, Dreier, David A, Lu, Haitian, Ramanarayanan, Tharacad, Ryan, Natalia, Watkins, Odette A, Wolf, Douglas C

“…In 2019, the US EPA Administrator issued a directive directing the agency away from reliance on vertebrate tests by 2035, whilst maintaining high-quality human…”
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Ecotoxico-lipidomics: An emerging concept to understand chemical-metabolic relationships in comparative fish models by Dreier, David A., Bowden, John A., Aristizabal-Henao, Juan J., Denslow, Nancy D., Martyniuk, Christopher J.

“…Lipids play an essential role in development, homeostatic functions, immune signaling, reproduction, and growth. Although it is evident that changes in lipid…”
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How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? by Becker, Richard A., Dreier, David A., Manibusan, Mary K., Cox, Louis A. (Tony), Simon, Ted W., Bus, James S.

“…IARC has begun using ToxCast/Tox21 data in efforts to represent key characteristics of carcinogens to organize and weigh mechanistic evidence in cancer hazard…”
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Comparative endpoint sensitivity of in vitro estrogen agonist assays by Dreier, David A., Connors, Kristin A., Brooks, Bryan W.

“…•Estrogen agonist activity is assessed by numerous in vitro and in vivo model systems.•Comparative sensitivity among in vitro endpoints influences diagnostic…”
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Toward Sustainable Environmental Quality: Priority Research Questions for North America by Fairbrother, Anne, Muir, Derek, Solomon, Keith R., Ankley, Gerald T., Rudd, Murray A., Boxall, Alistair B.A., Apell, Jennifer N., Armbrust, Kevin L., Blalock, Bonnie J., Bowman, Sarah R., Campbell, Linda M., Cobb, George P., Connors, Kristin A., Dreier, David A., Evans, Marlene S., Henry, Carol J., Hoke, Robert A., Houde, Magali, Klaine, Stephen J., Klaper, Rebecca D., Kullik, Sigrun A., Lanno, Roman P., Meyer, Charles, Ottinger, Mary Ann, Oziolor, Elias, Petersen, Elijah J., Poynton, Helen C., Rice, Pamela J., Rodriguez‐Fuentes, Gabriela, Samel, Alan, Shaw, Joseph R., Steevens, Jeffery A., Verslycke, Tim A., Vidal‐Dorsch, Doris E., Weir, Scott M., Wilson, Peter, Brooks, Bryan W.

“…Anticipating, identifying, and prioritizing strategic needs represent essential activities by research organizations. Decided benefits emerge when these…”
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Toward an adverse outcome pathway for impaired growth: Mitochondrial dysfunction impairs growth in early life stages of the fathead minnow (Pimephales promelas) by Bolser, Derek G., Dreier, David A., Li, Erchao, Kroll, Kevin J., Martyniuk, Christopher J., Denslow, Nancy D.

“…Chemical contaminants present in the environment can affect mitochondrial bioenergetics in aquatic organisms and can have substantial effects on individual…”
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Challenges in assigning endocrine‐specific modes of action: Recommendations for researchers and regulators by Mihaich, Ellen M, Schäfers, Christoph, Dreier, David A, Hecker, Markus, Ortego, Lisa, Kawashima, Yukio, Dang, Zhi‐Chao, Solomon, Keith

“…ABSTRACT As regulatory programs evaluate substances for their endocrine‐disrupting properties, careful study design and data interpretation are needed to…”
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Computational analysis of the ToxCast estrogen receptor agonist assays to predict vitellogenin induction by chemicals in male fish by Dreier, David A, Denslow, Nancy D, Martyniuk, Christopher J

“…Highlights • ToxCast ER agonist assays significantly predicted male vitellogenin induction. • The ToxCast ER agonist model had similar performance to…”
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Advancing the assessment of population stability as a protection goal in ecotoxicology by Dreier, David A, Weltje, Lennart, Wheeler, James R

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Integrating Exposure and Effect Distributions with the Ecotoxicity Risk Calculator: Case Studies with Crop Protection Products by Dreier, David A, Rodney, Sara I, Moore, Dwayne RJ, Grant, Shanique L, Chen, Wenlin, Valenti, Theodore W, Brain, Richard A

“…ABSTRACT Risk curves describe the relationship between cumulative probability and magnitude of effect and thus express far more information than risk…”
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Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine‐active substances by Matthiessen, Peter, Ankley, Gerald T, Biever, Ronald C, Bjerregaard, Poul, Borgert, Christopher, Brugger, Kristin, Blankinship, Amy, Chambers, Janice, Coady, Katherine K, Constantine, Lisa, Dang, Zhichao, Denslow, Nancy D, Dreier, David A, Dungey, Steve, Gray, L Earl, Gross, Melanie, Guiney, Patrick D, Hecker, Markus, Holbech, Henrik, Iguchi, Taisen, Kadlec, Sarah, Karouna‐Renier, Natalie K, Katsiadaki, Ioanna, Kawashima, Yukio, Kloas, Werner, Krueger, Henry, Kumar, Anu, Lagadic, Laurent, Leopold, Annegaaike, Levine, Steven L, Maack, Gerd, Marty, Sue, Meador, James, Mihaich, Ellen, Odum, Jenny, Ortego, Lisa, Parrott, Joanne, Pickford, Daniel, Roberts, Mike, Schaefers, Christoph, Schwarz, Tamar, Solomon, Keith, Verslycke, Tim, Weltje, Lennart, Wheeler, James R, Williams, Mike, Wolf, Jeffrey C, Yamazaki, Kunihiko

“…ABSTRACT A SETAC Pellston Workshop® “Environmental Hazard and Risk Assessment Approaches for Endocrine‐Active Substances (EHRA)” was held in February 2016 in…”
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The influence of breeding strategy, reproductive stage, and tissue type on transcript variability in fish by Dreier, David A., Loughery, Jennifer R., Denslow, Nancy D., Martyniuk, Christopher J.

“…Characterizing factors that contribute to transcript variability is necessary before molecular endpoints are widely adopted as biomarkers for environmental…”
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Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators: Assigning Endocrine-Specific Modes of Action by Mihaich, Ellen M, Schäfers, Christoph, Dreier, David A, Hecker, Markus, Ortego, Lisa, Kawashima, Yukio, Dang, Zhi-Chao, Solomon, Keith

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