Search Results - "Dreier, Birgit"

Rapid selection of high-affinity binders using ribosome display by Dreier, Birgit, Plückthun, Andreas

“…Ribosome display has proven to be a powerful in vitro selection and evolution method for generating high-affinity binders from libraries of folded proteins. It…”
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Structural basis of adenylyl cyclase 9 activation by Qi, Chao, Lavriha, Pia, Mehta, Ved, Khanppnavar, Basavraj, Mohammed, Inayathulla, Li, Yong, Lazaratos, Michalis, Schaefer, Jonas V., Dreier, Birgit, Plückthun, Andreas, Bondar, Ana-Nicoleta, Dessauer, Carmen W., Korkhov, Volodymyr M.

“…Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein…”
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Structure of a kinesin–tubulin complex and implications for kinesin motility by Gigant, Benoît, Wang, Weiyi, Dreier, Birgit, Jiang, Qiyang, Pecqueur, Ludovic, Plückthun, Andreas, Wang, Chunguang, Knossow, Marcel

“…Combined with kinetic analyses, the high resolution structure of kinesin-1 bound to a tubulin dimer offers a much-anticipated view of the motor-microtubule…”
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control by Schmid, Markus, Ernst, Patrick, Honegger, Annemarie, Suomalainen, Maarit, Zimmermann, Martina, Braun, Lukas, Stauffer, Sarah, Thom, Cristian, Dreier, Birgit, Eibauer, Matthias, Kipar, Anja, Vogel, Viola, Greber, Urs F., Medalia, Ohad, Plückthun, Andreas

“…Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic…”
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Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system by Blanc, Marine, Lettl, Clara, Guérin, Jérémy, Vieille, Anaïs, Furler, Sven, Briand-Schumacher, Sylvie, Dreier, Birgit, Bergé, Célia, Plückthun, Andreas, Vadon-Le Goff, Sandrine, Fronzes, Rémi, Rousselle, Patricia, Fischer, Wolfgang, Terradot, Laurent

“…The bacterial human pathogen Helicobacter pylori produces a type IV secretion system (cagT4SS) to inject the oncoprotein CagA into gastric cells. The cagT4SS…”
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A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology by Campbell, Benjamin FN, Dittmann, Antje, Dreier, Birgit, Plückthun, Andreas, Tyagarajan, Shiva K

“…Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence,…”
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designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end by Pecqueur, Ludovic, Duellberg, Christian, Dreier, Birgit, Jiang, Qiyang, Wang, Chunguang, Plückthun, Andreas, Surrey, Thomas, Gigant, Benoît, Knossow, Marcel

“…Microtubules are cytoskeleton filaments consisting of αβ-tubulin heterodimers. They switch between phases of growth and shrinkage. The underlying mechanism of…”
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Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins by Nowak, Kathrin, Rosenthal, Florian, Karlberg, Tobias, Bütepage, Mareike, Thorsell, Ann-Gerd, Dreier, Birgit, Grossmann, Jonas, Sobek, Jens, Imhof, Ralph, Lüscher, Bernhard, Schüler, Herwig, Plückthun, Andreas, Leslie Pedrioli, Deena M., Hottiger, Michael O.

“…Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins…”
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Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways by Wang, Longlong, Moreira, Etori Aguiar, Kempf, Georg, Miyake, Yasuyuki, Oliveira Esteves, Blandina I., Fahmi, Amal, Schaefer, Jonas V., Dreier, Birgit, Yamauchi, Yohei, Alves, Marco P., Plückthun, Andreas, Matthias, Patrick

“…The deacetylase HDAC6 has tandem catalytic domains and a zinc finger domain (ZnF) binding ubiquitin (Ub). While the catalytic domain has an antiviral effect,…”
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Nuclear myosin VI maintains replication fork stability by Shi, Jie, Hauschulte, Kristine, Mikicic, Ivan, Maharjan, Srijana, Arz, Valerie, Strauch, Tina, Heidelberger, Jan B., Schaefer, Jonas V., Dreier, Birgit, Plückthun, Andreas, Beli, Petra, Ulrich, Helle D., Wollscheid, Hans-Peter

“…The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in the nucleus…”
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The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection by Bieri, Manuela, Hendrickx, Rodinde, Bauer, Michael, Yu, Bin, Jetzer, Tania, Dreier, Birgit, Mittl, Peer R E, Sobek, Jens, Plückthun, Andreas, Greber, Urs F, Hemmi, Silvio

“…Mammalian adenoviruses (AdVs) comprise more than ~350 types including over 100 human (HAdVs) and just three mouse AdVs (MAdVs). While most HAdVs initiate…”
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Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters by Dreier, Birgit, Honegger, Annemarie, Hess, Christian, Nagy-Davidescu, Gabriela, Mittl, Peer R E, Grütter, Markus G, Belousova, Natalya, Mikheeva, Galina, Krasnykh, Victor, Plückthun, Andreas

“…Adenoviruses (Ads) have shown promise as vectors for gene delivery in clinical trials. Efficient viral targeting to a tissue of choice requires both ablation…”
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DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma by Strubel, Alexander, Münick, Philipp, Hartmann, Oliver, Chaikuad, Apirat, Dreier, Birgit, Schaefer, Jonas V., Gebel, Jakob, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Buck, Viktoria, Rosenfeldt, Mathias, Knapp, Stefan, Plückthun, Andreas, Diefenbacher, Markus E., Dötsch, Volker

“…The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All…”
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Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors by Mann, Axel, Friedrich, Nikolas, Krarup, Anders, Weber, Jacqueline, Stiegeler, Emanuel, Dreier, Birgit, Pugach, Pavel, Robbiani, Melissa, Riedel, Tina, Moehle, Kerstin, Robinson, John A, Rusert, Peter, Plückthun, Andreas, Trkola, Alexandra

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors by Hartmann, Jessica, Münch, Robert C., Freiling, Ruth-Therese, Schneider, Irene C., Dreier, Birgit, Samukange, Washington, Koch, Joachim, Seeger, Markus A., Plückthun, Andreas, Buchholz, Christian J.

“…Delivering genes selectively to the therapeutically relevant cell type is among the prime goals of vector development. Here, we present a high-throughput…”
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A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors by Hartmann, Jessica, Münch, Robert C., Freiling, Ruth-Therese, Schneider, Irene C., Dreier, Birgit, Samukang, Washington, Koch, Joachim, Seeger, Markus A., Plückthun, Andreas, Buchholz, Christian J.

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Assessing immunogenicity barriers of the HIV-1 envelope trimer by Maliqi, Liridona, Friedrich, Nikolas, Glögl, Matthias, Schmutz, Stefan, Schmidt, Daniel, Rusert, Peter, Schanz, Merle, Zaheri, Maryam, Pasin, Chloé, Niklaus, Cyrille, Foulkes, Caio, Reinberg, Thomas, Dreier, Birgit, Abela, Irene, Peterhoff, David, Hauser, Alexandra, Kouyos, Roger D., Günthard, Huldrych F., van Gils, Marit J., Sanders, Rogier W., Wagner, Ralf, Plückthun, Andreas, Trkola, Alexandra

“…Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for broadly…”
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Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation by Reif, Raymond, Sales, Susanne, Hettwer, Stefan, Dreier, Birgit, Gisler, Claudio, Wölfel, Jens, Lüscher, Daniel, Zurlinden, Andreas, Stephan, Alexander, Ahmed, Shaheen, Baici, Antonio, Ledermann, Birgit, Kunz, Beat, Sonderegger, Peter

“…The synaptic serine protease neurotrypsin is thought to be important for adaptive synaptic processes required for cognitive functions, because humans deficient…”
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Positive and Negative Regulation of Endogenous Genes by Designed Transcription Factors by Beerli, Roger R., Dreier, Birgit, Barbas, Carlos F.

“…Gene regulation by imposed localization was studied by using designed zinc finger proteins that bind 18-bp DNA sequences in the 5′untranslated regions of the…”
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Toward Controlling Gene Expression at Will: Selection and Design of Zinc Finger Domains Recognizing Each of the 5′-GNN-3′DNA Target Sequences by Segal, David J., Dreier, Birgit, Beerli, Roger R., Barbas, Carlos F.

“…We have taken a comprehensive approach to the generation of novel DNA binding zinc finger domains of defined specificity. Herein we describe the generation and…”
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