BAFF Expression is Modulated by Female Hormones in Human Immune Cells

BAFF Expression is Modulated by Female Hormones in Human Immune Cells

Among several autoimmune diseases, one of the main risk factors is the female gender, and much consideration has been given to the involvement of female hormones in their etiology. B-cell activating factor (BAFF) is a key factor in survival and maturation of B cells and is overexpressed in several a...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical genetics Vol. 54; no. 5; pp. 722 - 730
Main Authors: Drehmer, Manuela N., Suterio, Dalila G., Muniz, Yara C. N., de Souza, Iliada R., Löfgren, Sara E.
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2016
Springer Nature B.V
Subjects:
Adult
Animals
B-Cell Activating Factor - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cells, Cultured
Discrimination
Estrogens
Estrogens - pharmacology
Etiology
Female
Gene Expression Regulation - drug effects
Hormones
Human Genetics
Humans
Leukocytes - cytology
Leukocytes - drug effects
Male
Medical Microbiology
Mice
Original Article
Progesterone - pharmacology
Risk factors
Up-Regulation
Young Adult
Zoology
BAFF
Autoimmune disease
Immunogenetics
Gene expression
Expertise in immunology
Female hormones
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among several autoimmune diseases, one of the main risk factors is the female gender, and much consideration has been given to the involvement of female hormones in their etiology. B-cell activating factor (BAFF) is a key factor in survival and maturation of B cells and is overexpressed in several autoimmune patients although the mechanism behind this feature is unclear. In murine models, BAFF expression could be upregulated by exogenous estrogen treatment in splenocytes; however, no evidence of this relationship was available in humans. Here, leukocytes from healthy male and female individuals were collected and cultivated in the presence or absence of estrogen or progesterone. BAFF gene expression was accessed by quantitative PCR and compared between treated and untreated group of cells. In the presence of estrogen, BAFF expression was upregulated by more than 5 times in both genders. When exposed to progesterone, the female-originated cells showed increased expression, while the cells of male origin a significant downregulation of BAFF. Our results suggest that female hormones can modulate the expression of BAFF, a key cytokine in autoimmune pathways, in human immune cells. These data might contribute to the understanding of the etiology as well as the gender bias featured by several autoimmune disorders.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-016-9752-y