Search Results - "Dreher, I."

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy by Diederichs, Solvig, Tonnier, Veronika, März, Melanie, Dreher, Simon I., Geisbüsch, Andreas, Richter, Wiltrud

“…Re-directing mesenchymal stromal cell (MSC) chondrogenesis towards a non-hypertrophic articular chondrocyte-(AC)-like phenotype is important for improving…”
Get full text

Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention by Dreher, Simon I., Irmler, Martin, Pivovarova-Ramich, Olga, Kessler, Katharina, Jürchott, Karsten, Sticht, Carsten, Fritsche, Louise, Schneeweiss, Patrick, Machann, Jürgen, Pfeiffer, Andreas F. H., Hrabě de Angelis, Martin, Beckers, Johannes, Birkenfeld, Andreas L., Peter, Andreas, Niess, Andreas M., Weigert, Cora, Moller, Anja

“…Background Exercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular adaptations of…”
Get full text

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept by Diederichs, Solvig, Dreher, Simon I, Nüesch, Sarah Anna, Schmidt, Sven, Merle, Christian, Richter, Wiltrud

“…In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields…”
Get full text

MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1 by Melnik, Svitlana, Gabler, Jessica, Dreher, Simon I, Hecht, Nicole, Hofmann, Nina, Großner, Tobias, Richter, Wiltrud

“…Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable…”
Get full text

Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells by Dreher, Simon I, Fischer, Jennifer, Walker, Tilman, Diederichs, Solvig, Richter, Wiltrud

“…Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal…”
Get full text

Immunotherapy of a squamous cell carcinoma in the perianal region using autologous dendritic cells in a horse by Arnold, C., Dreher, I., Grammel, T., Schusser, G. F.

“…Summary A 23‐year‐old Trakehner mare was referred to the Department of Large Animal Medicine with an ulcerative cleft tumour dorsal of the anus and in poor…”
Get full text

TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle by Dreher, Simon I, Höckele, Selina, Huypens, Peter, Irmler, Martin, Hoffmann, Christoph, Jeske, Tim, Hastreiter, Maximilian, Moller, Anja, Birkenfeld, Andreas L, Häring, Hans-Ulrich, Peter, Andreas, Beckers, Johannes, Hrabě de Angelis, Martin, Weigert, Cora

“…Physical training improves insulin sensitivity and can prevent type 2 diabetes (T2D). However, approximately 20% of individuals lack a beneficial outcome in…”
Get full text

IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype by Dreher, Simon I, Grubba, Paul, von Toerne, Christine, Moruzzi, Alessia, Maurer, Jennifer, Goj, Thomas, Birkenfeld, Andreas L, Peter, Andreas, Loskill, Peter, Hauck, Stefanie M, Weigert, Cora

“…Skeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human…”
Get more information

Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) by Sandforth, Arvid, von Schwartzenberg, Reiner Jumpertz, Arreola, Elsa Vazquez, Hanson, Robert L, Sancar, Gencer, Katzenstein, Sarah, Lange, Karl, Preißl, Hubert, Dreher, Simon I, Weigert, Cora, Wagner, Robert, Kantartzis, Kostantinos, Machann, Jürgen, Schick, Fritz, Lehmann, Rainer, Peter, Andreas, Katsouli, Nikoletta, Ntziachristos, Vasilis, Dannecker, Corinna, Fritsche, Louise, Perakakis, Nikolaos, Heni, Martin, Nawroth, Peter Paul, Kopf, Stefan, Pfeiffer, Andreas F H, Kabisch, Stefan, Stumvoll, Michael, Schwarz, Peter E H, Hauner, Hans, Lechner, Andreas, Seissler, Jochen, Yurchenko, Iryna, Icks, Andrea, Solimena, Michele, Häring, Hans-Ulrich, Szendroedi, Julia, Schürmann, Annette, de Angelis, Martin Hrabé, Blüher, Matthias, Roden, Michael, Bornstein, Stefan R, Stefan, Norbert, Fritsche, Andreas, Birkenfeld, Andreas L

“…Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion…”
Get full text

Expression of Selenoproteins in Various Rat and Human Tissues and Cell Lines by Dreher, I., Schmutzler, C., Jakob, F., Köhrle, J.

“…Various rat and human tissues and cell lines naturally exposed to endogenous or exogenous oxidative stress were examined for their pattern of selenoprotein…”
Get full text

Selenoproteins Are Expressed in Fetal Human Osteoblast-like Cells by Dreher, I., Schütze, N., Baur, A., Hesse, K., Schneider, D., Köhrle, J., Jakob, F.

“…Selenoproteins are involved in mechanisms of cell differentiation and defense. We investigated the expression of glutathione peroxidases, as well as other…”
Get full text

The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis by PRANDINI, Marie-Hélène, DREHER, Inge, BOUILLOT, Stéphanie, BENKERRI, Souhila, MOLL, Thomas, HUBER, Philippe

“…Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the…”
Get full text

598-P: Sex-Specific Differences of Human Skeletal Muscle-A Multiomics Exercise Study by Dreher, Simon I, Goj, Thomas, Von Toerne, Christine, Hoene, Miriam, Irmler, Martin, Ouni, Meriem, Jähnert, Markus, Beckers, Johannes, Peter, Andreas, Birkenfeld, Andreas L, Schürmann, Annette, Hauck, Stefanie M, Weigert, Cora

“…Exercise is a potent skeletal muscle stimulus and one of the most effective strategies to prevent muscle loss and type 2 diabetes. Biological sex-based…”
Get full text

Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells by Jakobs, TC, Mentrup, B, Schmutzler, C, Dreher, I, Kohrle, J

“…OBJECTIVE: The sick euthyroid syndrome in critically ill patients without primary disease of the thyroid gland is characterised by low serum total…”
Get full text

Cloning and characterization of the human selenoprotein P promoter. Response of selenoprotein P expression to cytokines in liver cells by Dreher, I, Jakobs, T C, Köhrle, J

“…We isolated an 18-kilobase (kb) genomic selenoprotein P clone from a human placenta library and cloned, sequenced, and characterized the 5'-flanking region of…”
Get full text

Modulation of selenoprotein P expression by TGF-beta(1) is mediated by Smad proteins by Mostert, V, Dreher, I, Köhrle, J, Wolff, S, Abel, J

“…Selenoprotein P (SeP) is a selenium-rich plasma protein which accounts for more than 50% this study, the effect of TGF-beta(1) on the expression of SeP in the…”
Get full text

The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2 by Hesse-Bähr, K, Dreher, I, Köhrle, J

“…Metabolic labeling of HepG2 cells with 75selenite indicated the expression of more than four selenoproteins in the 80 to 45 kDa range and more than four…”
Get full text

Transforming growth factor-beta1 inhibits expression of selenoprotein P in cultured human liver cells by Mostert, V, Dreher, I, Kohrle, J, Abel, J

“…The effect of cytokines on the expression of selenoprotein P (SeP) in the human liver cell line HepG2 was investigated. Treatment with interleukin-1beta,…”
Get full text

The influence of the cytokines Il-1β and INFγ on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2 by Hesse-Bähr, K., Dreher, I., Körle, J.

“…Metabolic labeling of HepG2 cells with 75selenite indicated the expression of more than four selenoproteins in the 80 to 45 kDa range and more than four…”
Get full text

Expression pattern of gastrointestinal selenoproteins--targets for selenium supplementation by Mork, H, Lex, B, Scheurlen, M, Dreher, I, Schutze, N, Kohrle, J, Jakob, F

“…There is experimental and epidemiological evidence for an association between low selenium levels and gastrointestinal cancer incidence, prevalence, and…”
Get full text