Search Results - "Drege, Emmanuelle"

Carbon Nucleophile-Initiated Rauhut–Currier Reaction: An Atom-Economical Synthesis of Highly Functionalized Carbocycles by Gigant, Nicolas, Drège, Emmanuelle, Joseph, Delphine

“…A Rauhut–Currier reaction cascade is achieved in the presence of carbon nucleophiles under mild conditions. This original atom-economical transformation…”
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Enantioselective Total Synthesis of the Neurotoxin Caramboxin by Derrien, Benoit, Leblanc, Karine, Evanno, Laurent, Drège, Emmanuelle

“…Herein, we report the first and efficient asymmetric total synthesis of the neurotoxin (−)-caramboxin. The key to success is the creation of a stereogenic…”
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Metal-free synthesis of γ-ketosulfones through Brønsted acid-promoted conjugate addition of sulfinamides by Gigant, Nicolas, Kayal, Sami, Drège, Emmanuelle, Joseph, Delphine

“…A straightforward and general metal-free method has been developed to add sufinamide-derived sulfone units on Michael acceptors under mild conditions. This…”
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Access to Highly Functionalized Sulfonated Cyclopentanes by Acid-Promoted Rauhut-Currier Reaction with Sulfinamides by Gigant, Nicolas, Drège, Emmanuelle, Retailleau, Pascal, Joseph, Delphine

“…An unexpected acid‐mediated cascade reaction induced by conjugate addition of sulfinamides to dienediones has been developed. This highly efficient…”
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Step-Economical Access to Valuable Weinreb Amide 2,5-Disubstituted Pyrrolidines by a Sequential One-Pot Two-Directional Cross-Metathesis/Cyclizing Aza-Michael Process by Boufroura, Hamza, Mauduit, Marc, Drège, Emmanuelle, Joseph, Delphine

“…Double cross-metathesis of 1,5-hexadiene with a variety of electron-deficient alkenes including the reluctant Weinreb acrylamide has been successfully…”
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Identification of a pre-active conformation of a pentameric channel receptor by Menny, Anaïs, Lefebvre, Solène N, Schmidpeter, Philipp Am, Drège, Emmanuelle, Fourati, Zaineb, Delarue, Marc, Edelstein, Stuart J, Nimigean, Crina M, Joseph, Delphine, Corringer, Pierre-Jean

“…Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several…”
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Two-Component Domino Reactions Initiated from Ketenes: Serendipitous Synthesis of Quinolizidinones Analogous to Chelated Lobeline’s Conformation by Drège, Emmanuelle, Venot, Pierre-Etienne, Le Bideau, Franck, Retailleau, Pascal, Joseph, Delphine

“…An original and efficient synthesis of quinolizidinones through a one-pot two-component cascade reaction of norlobelanine with in situ generated ketenes is…”
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Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State by Fourati, Zaineb, Ruza, Reinis Reinholds, Laverty, Duncan, Drège, Emmanuelle, Delarue-Cochin, Sandrine, Joseph, Delphine, Koehl, Patrice, Smart, Trevor, Delarue, Marc

“…Barbiturates induce anesthesia by modulating the activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs). Despite more than a century of…”
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Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues by Amara, Zacharias, Drège, Emmanuelle, Troufflard, Claire, Retailleau, Pascal, Joseph, Delphine

“…Novel 2,5-meso-pyrrolidines have been straightforwardly synthesized from readily available symmetrical double Michael acceptors. The key step rested on an…”
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Amine-mediated tandem conjugative isomerization-bridging Michael addition: concise synthesis of 1-azabicyclo[3.3.1]nonanes by Ngo, Anh Ngoc, El Kassimi, Khadija, Amara, Zacharias, Drège, Emmanuelle, Joseph, Delphine

“…To reach densely functionalized 1-azabicyclo[3.3.1]nonane frameworks synthesis, a stereocontrolled bridging Michael addition involving an unexplored C-5/C-6…”
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A Facile and Stereocontrolled Synthesis of γ-Substituted γ-Fluoroglutamates by Conjugate Addition: Conflicting Effect between Fluorinated Enaminoester and Hinderered Michael Acceptor by Drège, Emmanuelle, Guillaume, Anaïs, Boukhedimi, Nadjia, Marrot, Jérôme, Troufflard, Claire, Tran Huu-Dau, Marie-Elise, Joseph, Delphine, Delarue-Cochin, Sandrine

“…Asymmetric Michael addition of chiral 2-fluoroenaminoesters derived from (S)-1-phenylethylamine to α-substituted methyl acrylate leads to diastereomeric…”
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Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Shut State by Fourati, Zeineb, Ruza, Reinis R., Laverty, Duncan, Drege, Emmanuelle, Delarue-Cochin, Sandrine, Joseph, Delphine, Koehl, Patrice, Smart, Trevor, Delarue, Marc

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Synthetic Studies on Cyathin Terpenoids: Enantioselective Synthesis of the Tricyclic Core of Cyathin through Intramolecular Heck Cyclisation by Drège, Emmanuelle, Tominiaux, Cyrille, Morgant, Georges, Desmaële, Didier

“…An enantioselective synthesis of the tricyclic ketone (+)‐5, which displays the carbon core of NGF‐inducing cyathane diterpenes, has been completed according…”
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Asymmetric synthesis of the tricyclic core of cyathin diterpenoids via intramolecular Heck reaction by Drège, Emmanuelle, Morgant, Georges, Desmaële, Didier

“…The tricyclic ketone 1 , which displays the ring system of cyathin diterpenes was assembled from 2-methylcyclopentanone through a sequence involving…”
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