Search Results - "Dredge, K."

The evolution of thalidomide and its IMiD derivatives as anticancer agents by Bartlett, J. Blake, Dredge, Keith, Dalgleish, Angus G

“…Thalidomide was originally used to treat morning sickness, but was banned in the 1960s for causing serious congenital birth defects. Remarkably, thalidomide…”
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PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models by Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I

“…Background: PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix…”
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The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy by Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V., Bytheway, I.

“…Summary Heparan sulfate mimetics, which we have called the PG500 series, have been developed to target the inhibition of both angiogenesis and heparanase…”
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Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects by DREDGE, K, MARRIOTT, J. B, MACDONALD, C. D, MAN, H-W, CHEN, R, MULLER, G. W, STIRLING, D, DALGLEISH, A. G

“…The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties. Second generation thalidomide analogues are distinct compounds…”
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Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers by BARTLETT, J. B, MICHAE, A, ZELDIS, J, DALGLEISH, A. G, CLARKE, I. A, DREDGE, K, NICHOLSON, S, KRISTELEIT, H, POLYCHRONIS, A, PANDHA, H, MULLER, G. W, STIRLING, Dl

“…We assessed the safety, tolerability and efficacy of the immunomodulatory drug, CC-5013 (REVIMID trade mark ), in the treatment of patients with metastatic…”
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Abstract 1: The novel heparin sulfate (HS) mimetic PG545 shows strong synergism when combined with cisplatin and paclitaxel in preclinical ovarian cancer models by Freyer, L, Teoman, A, von Bismarck, A, Dredge, K, Shridhar, V

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Thalidomide and its analogues have distinct and opposing effects on TNF‐α and TNFR2 during co‐stimulation of both CD4+ and CD8+ T cells by MARRIOTT, J. B., CLARKE, I. A., DREDGE, K., MULLER, G., STIRLING, D., DALGLEISH, A. G.

“…Summary Thalidomide (Thd) is clinically useful in a number of conditions where its efficacy is probably related to its anti‐TNF‐α activity. More recently, Thd…”
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Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity by Dredge, Keith, Marriott, J. Blake, Todryk, Stephen M, Muller, George W, Chen, Roger, Stirling, David I, Dalgleish, Angus G

“…Thalidomide and its novel T cell costimulatory analogs (immunomodulatory drugs) are currently being assessed in the treatment of patients with advanced cancer…”
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polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer by Dredge, K, Kink, J. A, Johnson, R. M, Bytheway, I, Marton, L. J

“…Purpose PG11047 is a polyamine analog currently in Phase I trials for advanced cancer as a monotherapy and in combination with a number of approved anti-cancer…”
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The dual angiogenesis/metastasis inhibitor PG545 inhibits growth factor-induced cell migration and invasion in vitro and tumor growth in vivo of ovarian cancer cells by Giri, S, Winterhoff, B, Maguire, J, Teoman, A, Dredge, K, Shridhar, V

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Adjuvants and the promotion of Th1-type cytokines in tumour immunotherapy by DREDGE, Keith, MARRIOTT, J. Blake, TODRYK, Stephen M, DALGLEISH, Angus G

“…Immunotherapy includes both active and passive mechanisms that have the potential to treat many tumour types. Whereas monoclonal antibodies may kill cells by…”
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Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro by Dredge, Keith, Horsfall, Rebecca, Robinson, Simon P., Zhang, Ling-Hua, Lu, Ling, Tang, Yang, Shirley, Michael A., Muller, George, Schafer, Peter, Stirling, David, Dalgleish, Angus G., Bartlett, J. Blake

“…The thalidomide analogue and immunomodulatory drug (IMiD®) lenalidomide (CC-5013, REVLIMID™) is emerging as a useful treatment for a number of cancers and has…”
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Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D 3 and two synthetic analogues in three in vivo models of prostate cancer by Oades, G.M., Dredge, K., Kirby, R.S., Colston, K.W.

“…Objective  To determine the in vitro and in vivo effects of 1,25‐dihydroxyvitamin D 3 (calcitriol) and two newer less hypercalcaemic analogues, EB1089 and…”
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Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D3 and two synthetic analogues in three in vivo models of prostate cancer by Oades, G.M., Dredge, K., Kirby, R.S., Colston, K.W.

“…Objective  To determine the in vitro and in vivo effects of 1,25‐dihydroxyvitamin D 3 (calcitriol) and two newer less hypercalcaemic analogues, EB1089 and…”
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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins by MARRIOTT, J. Blake, CLARKE, Ian A, DALGLEISH, Angus G, CZAJKA, Anna, DREDGE, Keith, CHILDS, Kay, MAN, Hon-Wah, SCHAFER, Peter, GOVINDA, Sowmya, MULLER, George W, STIRLING, David I

“…Thalidomide is clinically useful in a number of cancers. Antitumor activity may be related to a number of known properties, including anti-tumor necrosis…”
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Thalidomide analogs as emerging anti-cancer drugs by Dredge, Keith, Dalgleish, Angus G, Marriott, J Blake

“…Recently, it has been demonstrated that a number of novel thalidomide analogs possess anti-cancer properties due to their T cell co-stimulatory,…”
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Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression by Harkin, Andrew, Kelly, John P, McNamara, Mairead, Connor, Thomas J, Dredge, Keith, Redmond, Anna, Leonard, Brian E

“…The limitations of antidepressant drugs to treat depression has warranted ongoing research to identify pharmacological agents and strategies which offer a…”
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Immunological effects of thalidomide and its chemical and functional analogs by Dredge, Keith, Marriott, J Blake, Dalgleish, Angus G

“…Thalidomide has recently shown considerable promise in the treatment of a number of conditions, such as leprosy and cancer. Its effectiveness in the clinic has…”
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Novel Vibrio cholerae O139 genes involved in lipopolysaccharide biosynthesis by Stroeher, U H, Parasivam, G, Dredge, B K, Manning, P A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Efficacy of intramammary treatment with procaine penicillin G vs. procaine penicillin G plus neomycin in bovine clinical mastitis caused by penicillin-susceptible, gram-positive bacteria - a double blind field study by Taponen, S., Dredge, K., Henriksson, B., Pyyhtiä, A.-M., Suojala, L., Junni, R., Heinonen, K., Pyörälä, S.

“…The efficacy of intramammary treatments containing procaine penicillin G alone (treatment A) or a combination of procaine penicillin G and neomycin (treatment…”
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