Search Results - "Dreden, Patrick Van"
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Combined Vaccination Approaches for COVID-19. Will These Improve the Efficacy Spectrum?
Published in Clinical and applied thrombosis/hemostasis (2021)Get full text
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Endothelial Cell Activation and Thrombin Generation Assessment for the Risk of Severe Early Onset Preeclampsia. the ROADMAP-EOP Study
Published in Clinical and applied thrombosis/hemostasis (01-01-2022)“…Background The ROADMAP-EOP study aimed to identify clinically relevant biomarkers of hypercoagulability for the identification of pregnant women at risk of…”
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Prospective Assessment of Biomarkers of Hypercoagulability for the Identification of Patients With Severe Coronary Artery Disease. The ROADMAP-CAD Study
Published in Clinical and applied thrombosis/hemostasis (2020)“…In patients with stable coronary artery disease (CAD) blood hypercoagulability figures among factors leading to thrombosis. Tissue factor (TF) exposure at…”
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HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease
Published in Journal of neuroinflammation (24-08-2016)“…The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer's disease (AD) that precedes the hallmarks of amyloid beta (amyloid β)…”
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Different sensitivity of von Clauss reagents for the diagnosis of dysfibrinogenemia
Published in European journal of haematology (01-01-2020)Get full text
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PARP Inhibitor Inhibits the Vasculogenic Mimicry through a NF-κB-PTX3 Axis Signaling in Breast Cancer Cells
Published in International journal of molecular sciences (18-12-2022)“…Poly (ADP-ribose) polymerase inhibitors (PARPi) are targeted therapies that inhibit PARP proteins which are involved in a variety of cell functions. PARPi may…”
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Extracellular vesicles derived from pancreatic cancer cells BXPC3 or breast cancer cells MCF7 induce a permanent procoagulant shift to endothelial cells
Published in Thrombosis research (01-03-2020)“…AbstractThe endothelium could be a potential target of cancer cell derived extracellular vesicles (CaCe-dEV). We investigated in vitro the effect of CaCe-dEV…”
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Potential utility of a multi-component coagulation factor panel to calculate MELD scores and assess the risk of portal vein thrombosis in chronic liver disease
Published in BMC gastroenterology (09-03-2023)“…Current quantitative approaches to assess chronic liver disease (CLD) severity have limitations. Further, portal vein thrombosis (PVT) pre-liver transplant…”
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Longer procoagulant phospholipid-dependent clotting time, lower endogenous thrombin potential and higher tissue factor pathway inhibitor concentrations are associated with increased VTE occurrence in patients with newly diagnosed multiple myeloma: results of the prospective ROADMAP-MM-CAT study
Published in Blood cancer journal (New York) (07-11-2018)“…Venous thromboembolism (VTE) is a common complication in newly diagnosed symptomatic multiple myeloma (NDMM) patients. We explored cellular and plasma…”
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Elevated circulating soluble thrombomodulin activity, tissue factor activity and circulating procoagulant phospholipids: New and useful markers for pre-eclampsia?
Published in European journal of obstetrics & gynecology and reproductive biology (01-09-2009)“…Abstract Objective One of the most frequently proposed mechanisms for pre-eclampsia refers to uteroplacental thrombosis. However, the contribution of classical…”
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Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability
Published in BMC cancer (22-12-2014)“…In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of…”
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Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemia
Published in British journal of haematology (01-02-2010)“…Summary The use of l‐asparaginase (l‐ASP) in paediatric patients with acute lymphoblastic leukaemia (ALL) is associated with thrombotic complications. We…”
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Endothelial dysfunction and hypercoagulability in severe sickle-cell acute chest syndrome
Published in ERJ open research (01-10-2021)“…Acute pulmonary hypertension (PH) may develop during sickle-cell acute chest syndrome (ACS), and is associated with an increased mortality. Its mechanisms…”
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Tissue factor over-expression by human pancreatic cancer cells BXPC3 is related to higher prothrombotic potential as compared to breast cancer cells MCF7
Published in Thrombosis research (01-06-2012)“…Abstract Cancer histology influences the risk of venous thromboembolism and tissue factor (TF) is the key molecule in cancer-induced hypercoagulability. We…”
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Prevalence of antiphospholipid antibodies in psychiatric patients users and non‐users of antipsychotics
Published in British journal of haematology (01-01-2014)“…Summary Past reports have suggested that antiphospholipid (aPL) antibodies may emerge as a response to antipsychotics treatment, as a high prevalence of aPL…”
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High Plasma Levels of Activated Factor VII-Antithrombin Complex Point to Increased Tissue Factor Expression in Patients with SARS-CoV-2 Pneumonia: A Potential Link with COVID-19 Prothrombotic Diathesis
Published in Diagnostics (Basel) (01-11-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of coronavirus disease 2019 (COVID-19), in which coagulation abnormalities and…”
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The Antithrombotic Potential of Tinzaparin and Enoxaparin Upon Thrombin Generation Triggered In Vitro by Human Ovarian Cancer Cells IGROV1
Published in Clinical and applied thrombosis/hemostasis (01-03-2017)“…A documented relationship between ovarian cancer and thrombosis does exist. Low-molecular-weight heparins (LMWHs) are cornerstone drugs in the primary…”
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Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots
Published in Research and practice in thrombosis and haemostasis (01-10-2018)“…Venous thromboembolism (VTE) is associated with significant morbidity and mortality. We investigated the impact of direct and AT‐dependent FXa or thrombin…”
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Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study
Published in Thrombosis journal (28-03-2017)“…Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We…”
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Treatment Resistance Risk in Patients with Newly Diagnosed Multiple Myeloma Is Associated with Blood Hypercoagulability: The ROADMAP-MM Study
Published in Hemato (01-03-2022)“…Biomarkers of hypercoagulability are potential candidates for the evaluation of risk for primary treatment resistance in patients with newly diagnosed multiple…”
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