Search Results - "Dreau, Didier"

CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration by Nguyen, Khanh T.P., Druhan, Lawrence J., Avalos, Belinda R., Zhai, Li, Rauova, Lubica, Nesmelova, Irina V., Dréau, Didier

“…Despite improvements in cancer early detection and treatment, metastatic breast cancer remains deadly. Current therapeutic approaches have very limited…”
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Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma by Yazdanifar, Mahboubeh, Zhou, Ru, Grover, Priyanka, Williams, Chandra, Bose, Mukulika, Moore, Laura J, Wu, Shu-Ta, Maher, John, Dreau, Didier, Mukherjee, And Pinku

“…Chimeric antigen receptor (CAR) T cells have shown remarkable success in treating hematologic cancers. However, this efficacy has yet to translate to treatment…”
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A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease by Park, Joseph, Wetzel, Isaac, Marriott, Ian, Dréau, Didier, D’Avanzo, Carla, Kim, Doo Yeon, Tanzi, Rudolph E., Cho, Hansang

“…Alzheimer’s disease (AD) is characterized by beta-amyloid accumulation, phosphorylated tau formation, hyperactivation of glial cells, and neuronal loss. The…”
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Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease by Brar, Sukhdev S, Grigg, Claude, Wilson, Kimberly S, Holder, Jr, Walter D, Dreau, Didier, Austin, Catherine, Foster, Mareva, Ghio, Andrew J, Whorton, A Richard, Stowell, Grayson W, Whittall, Linda B, Whittle, Robert R, White, David P, Kennedy, Thomas P

“…The thiocarbamate alcoholism drug disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-κB, sensitizes tumors…”
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Heterodimers Are an Integral Component of Chemokine Signaling Repertoire by Kaffashi, Kimia, Dréau, Didier, Nesmelova, Irina V

“…Chemokines are a family of signaling proteins that play a crucial role in cell-cell communication, cell migration, and cell trafficking, particularly…”
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Nanoparticle combination for precise stroma modulation and improved delivery for pancreatic cancer by Tarannum, Mubin, Holtzman, Katherine, Dréau, Didier, Mukherjee, Pinku, Vivero-Escoto, Juan L.

“…Therapeutic success in the treatment of pancreatic ductal adenocarcinoma (PDAC) is hindered by the extensive stroma associated to this disease. Stroma is…”
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3D Miniaturization of Human Organs for Drug Discovery by Park, Joseph, Wetzel, Isaac, Dréau, Didier, Cho, Hansang

“…“Engineered human organs” hold promises for predicting the effectiveness and accuracy of drug responses while reducing cost, time, and failure rates in…”
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A new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms by Nguyen, Khanh T.P., Volkman, Brian, Dréau, Didier, Nesmelova, Irina V.

“…Chemokines form a family of proteins with critical roles in many biological processes in health and disease conditions, including cardiovascular, autoimmune…”
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Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo by Ke, Weina, Chandler, Morgan, Cedrone, Edward, Saito, Renata F., Rangel, Maria Cristina, de Souza Junqueira, Mara, Wang, Jian, Shi, Da, Truong, Nguyen, Richardson, Melina, Rolband, Lewis A., Dréau, Didier, Bedocs, Peter, Chammas, Roger, Dokholyan, Nikolay V., Dobrovolskaia, Marina A., Afonin, Kirill A.

“…The unbalanced coagulation of blood is a life-threatening event that requires accurate and timely treatment. We introduce a user-friendly biomolecular platform…”
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The Endothelin Axis Stimulates the Expression of Pro-Inflammatory Cytokines and Pro-Migratory Molecules in Breast Cancer by Jewell, Ashley N., Swamydas, Muthulekha, Castillo, Claudia I., Wyan, Heather, Allen, Lauren D., McDermott, Kerri A., Eddy, Jill M., Dréau, Didier

“…ABSTRACT We investigated the effects of the endothelin-1 (ET-1) receptor dual antagonist (Bosentan®) on the inflammatory cytokines and the chemoattractant…”
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Novel 3D printed bioactive SiC orthopedic screw promotes bone growth associated activities by macrophages, neurons, and osteoblasts by El-Ghannam, Ahmed, Sultana, Farjana, Dréau, Didier, Tiwari, Arjun, Yang, In Hong, AlFotawi, Randa, Knabe-Ducheyne, Christine

“…Ceramic additive manufacturing currently relies on binders or high-energy lasers, each with limitations affecting final product quality and suitability for…”
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REV7-p53 interaction inhibits ATM-mediated DNA damage signaling by Biller, Megan, Kabir, Sara, Boado, Chkylle, Nipper, Sarah, Saffa, Alexandra, Tal, Ariella, Allen, Sydney, Sasanuma, Hiroyuki, Dréau, Didier, Vaziri, Cyrus, Tomida, Junya

“…REV7 is an abundant, multifunctional protein that is a known factor in cell cycle regulation and in several key DNA repair pathways including Trans-Lesion…”
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Structure and Function of Porcine Arteries Are Preserved for up to 6 Days Using the HypoRP Cold-storage Solution by Dréau, Didier, Wang, Shangping, Clemens, Mark, Elliott, Gloria D.

“…BACKGROUND.Maintaining functional vessels during preservation of vascularized composite allografts (VCAs) remains a major challenge. The University of…”
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Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model by Dréau, Didier, Moore, Laura Jeffords, Alvarez-Berrios, Merlis P, Tarannum, Mubin, Mukherjee, Pinku, Vivero-Escoto, Juan L

“…Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging…”
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Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial by Nieman, David C, Scherr, Johannes, Luo, Beibei, Meaney, Mary Pat, Dréau, Didier, Sha, Wei, Dew, Dustin A, Henson, Dru A, Pappan, Kirk L

“…Pistachio nut ingestion (3 oz./d, two weeks) was tested for effects on exercise performance and 21-h post-exercise recovery from inflammation, oxidative…”
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Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases by Swamydas, Muthulekha, Ricci, Krista, Rego, Stephen L., Dréau, Didier

“…Stromal chemokine gradients within the breast tissue microenvironment play a critical role in breast cancer cell invasion, a prerequisite to metastasis. To…”
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Immune and inflammation responses to a 3-day period of intensified running versus cycling by Nieman, David C, Luo, Beibei, Dréau, Didier, Henson, Dru A, Shanely, R. Andrew, Dew, Dustin, Meaney, Mary Pat

“…Highlight • This study showed that a 3-day period of intensified training resulted in substantially more muscle damage, soreness, and systemic inflammation in…”
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Breast tumor cell TACE-shed MCSF promotes pro-angiogenic macrophages through NF-κB signaling by Rego, Stephen L., Helms, Rachel S., Dréau, Didier

“…Most deaths associated with breast cancer, the most common malignancy in women, are caused by metastasis. Tumor associated macrophages significantly contribute…”
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Human Organ Miniaturization: 3D Miniaturization of Human Organs for Drug Discovery (Adv. Healthcare Mater. 2/2018) by Park, Joseph, Wetzel, Isaac, Dréau, Didier, Cho, Hansang

“…The cover artwork for the article number 1700551 by Hansang Cho and co‐workers reviews the current state‐of‐the‐art in engineering and miniaturizing human…”
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Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma by Dréau, Didier, Moore, Laura Jeffords, Wu, Mike, Roy, Lopa Das, Dillion, Lloye, Porter, Travis, Puri, Rahul, Momin, Noor, Wittrup, K Dane, Mukherjee, Pinku

“…Immunotherapy regimens have shown success in subsets of cancer patients; however, their efficacy against pancreatic ductal adenocarcinoma (PDA) remain unclear…”
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