Search Results - "Drdla, Ruth"

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy by Ruscheweyh, Ruth, Wilder-Smith, Oliver, Drdla, Ruth, Liu, Xian-Guo, Sandkühler, Jürgen

“…Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with hyperalgesia and has been proposed to be a cellular mechanism of pain…”
Get full text

Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal by Drdla, Ruth, Gassner, Matthias, Gingl, Ewald, Sandkühler, Jürgen

“…μ-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is,…”
Get full text

Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn by Ikeda, Hiroshi, Stark, Johanna, Fischer, Harald, Wagner, Matthias, Drdla, Ruth, Jäger, Tino, Sandkühler, Jürgen

“…Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord. The synaptic…”
Get full text

Selective activation of microglia facilitates synaptic strength by Clark, Anna K, Gruber-Schoffnegger, Doris, Drdla-Schutting, Ruth, Gerhold, Katharina J, Malcangio, Marzia, Sandkühler, Jürgen

“…Synaptic plasticity is thought to be initiated by neurons only, with the prevailing view assigning glial cells mere specify supportive functions for synaptic…”
Get full text

Central Nervous System Mast Cells in Peripheral Inflammatory Nociception by Xanthos, Dimitris N, Gaderer, Simon, Drdla, Ruth, Nuro, Erin, Abramova, Anastasia, Ellmeier, Wilfried, Sandkühler, Jürgen

“…Background: Functional aspects of mast cell-neuronal interactions remain poorly understood. Mast cell activation and degranulation can result in the release of…”
Get full text

Long-Term Potentiation at C-Fibre Synapses by Low-Level Presynaptic Activity in vivo by Drdla, Ruth, Sandkühler, Jürgen

“…Inflammation, trauma or nerve injury trigger low-level activity in C-fibres and may cause long-lasting hyperalgesia. Long-term potentiation (LTP) at synapses…”
Get full text

Erasure of a Spinal Memory Trace of Pain by a Brief, High-Dose Opioid Administration by Drdla-Schutting, Ruth, Benrath, Justus, Wunderbaldinger, Gabriele, Sandkühler, Jürgen

“…Painful stimuli activate nociceptive C fibers and induce synaptic long-term potentiation (LTP) at their spinal terminals. LTP at C-fiber synapses represents a…”
Get full text

Distinct mechanisms underlying pronociceptive effects of opioids by Heinl, Céline, Drdla-Schutting, Ruth, Xanthos, Dimitris N, Sandkühler, Jürgen

“…In addition to analgesia, opioids may also produce paradoxical pain amplification [opioid-induced hyperalgesia (OIH)] either on abrupt withdrawal or during…”
Get full text

Probing pain aversion in rats with the “Heat Escape Threshold” paradigm by Hogri, Roni, Baltov, Bozhidar, Drdla-Schutting, Ruth, Mussetto, Valeria, Raphael, Holzinger, Trofimova, Lidia, Sandkühler, Jürgen

“…The aversive aspect of pain constitutes a major burden faced by pain patients. This has been recognized by the pain research community, leading to the…”
Get full text

Researcher of the Month by Drdla, Ruth, Gassner, Matthias

Get full text

Induction of thermal hyperalgesia and synaptic long-term potentiation in the spinal cord lamina I by TNF-α and IL-1β is mediated by glial cells by Gruber-Schoffnegger, Doris, Drdla-Schutting, Ruth, Hönigsperger, Christoph, Wunderbaldinger, Gabriele, Gassner, Matthias, Sandkühler, Jürgen

“…Long-term potentiation (LTP) of synaptic strength in nociceptive pathways is a cellular model of hyperalgesia. The emerging literature suggests a role for…”
Get full text

Withdrawal from an opioid induces a transferable memory trace in the cerebrospinal fluid by Drdla-Schutting, Ruth, Heinl, Céline, Hadschieff, Viktoria, Sandkühler, Jürgen

“…Opioids are the most powerful analgesics available to date. However, they may also induce adverse effects including paradoxical opioid-induced hyperalgesia. A…”
Get full text

Fundamental sex differences in morphine withdrawal-induced neuronal plasticity by Hadschieff, Viktoria, Drdla-Schutting, Ruth, Springer, David Niklas, Siegert, Anna Siobhán Maria, Schroeder, Hanna, Sandkühler, Jürgen

“…Withdrawal from systemic opioids can induce long-term potentiation (LTP) at spinal C-fibre synapses ("opioid-withdrawal-LTP"). This is considered to be a…”
Get full text

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude by Gerhold, Katharina J, Drdla-Schutting, Ruth, Honsek, Silke D, Forsthuber, Liesbeth, Sandkühler, Jürgen

“…Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for…”
Get full text

A brief, high-dose remifentanil infusion partially reverses neuropathic pain in a subgroup of post herpetic neuralgia patients by Prosenz, Julian, Kloimstein, Herwig, Thaler, Ulrich, Drdla-Schutting, Ruth, Sandkühler, Jürgen, Gustorff, Burkhard

“…Highlights • Eleven of 20 patients responded to treatment. • The mean reduction of spontaneous pain was 61% among responders after seven days. • Patients who…”
Get full text

Researcher of the Month by Drdla-Schutting, Ruth

Get full text