Search Results - "Drayton, Ross M."

Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11 by DRAYTON, Ross M, DUDZIEC, Ewa, PETER, Stefan, BERTZ, Simone, HARTMANN, Arndt, BRYANT, Helen E, CATTO, James WF

“…Resistance to cisplatin-based chemotherapy is a major obstacle to bladder cancer treatment. We aimed to identify microRNAs (miRNA) that are dysregulated in…”
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The role of microRNA in the response to cisplatin treatment by Drayton, Ross M

“…Resistance to the cytotoxic effects of cisplatin can be mediated through changes in a wide variety of cellular processes and signalling pathways. The discovery…”
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Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells by Fathers, Catherine, Drayton, Ross M., Solovieva, Svetlana, Bryant, Helen E.

“…Poly(ADP-ribose) glycohydrolase (PARG), removes poly(ADP-ribose) subunits from proteins that have previously been modified by poly(ADP-ribose) polymerse. This…”
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Molecular mechanisms of cisplatin resistance in bladder cancer by Drayton, Ross M, Catto, James WF

“…Metastatic disease is the most common mechanism of death in patients with advanced bladder cancer. As for most solid tumors, chemotherapy remains the only…”
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MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer by Drayton, Ross M, Peter, Stefan, Myers, Katie, Miah, Saiful, Dudziec, Ewa, Bryant, Helen E, Catto, James W F

“…Urothelial cell carcinoma of the bladder (UCC) is a common disease often characterized by FGFR3 dysregulation. Whilst upregulation of this oncogene occurs most…”
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The Fanconi anemia pathway is downregulated upon macrophage differentiation through two distinct mechanisms by Lu, Wei-Ting, Lemonidis, Kimon, Drayton, Ross M., Nouspikel, Thierry

“…The Fanconi anemia (FA) pathway is a DNA-damage inducible pathway critical for genomic stability. FA patients typically display high cancer susceptibility and…”
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Identification of differentially expressed long noncoding RNAs in bladder cancer by Peter, Stefan, Borkowska, Edyta, Drayton, Ross M, Rakhit, Callum P, Noon, Aidan, Chen, Wei, Catto, James Wf

“…Loss of epigenetic gene regulation through altered long noncoding RNA (lncRNA) expression seems important in human cancer. LncRNAs have diagnostic and…”
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Identification and diagnostic performance of a small RNA within the PCA3 and BMCC1 gene locus that potentially targets mRNA by Drayton, Ross M, Rehman, Ishtiaq, Clarke, Raymond, Zhao, Zhongming, Pang, Karl, Miah, Saiful, Stoehr, Robert, Hartmann, Arndt, Blizard, Sheila, Lavin, Martin, Bryant, Helen E, Martens-Uzunova, Elena S, Jenster, Guido, Hamdy, Freddie C, Gardiner, Robert A, Catto, James W F

“…PCA3 is a long noncoding RNA (lncRNA) with unknown function, upregulated in prostate cancer. LncRNAs may be processed into smaller active species. We…”
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Reduced expression of microRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11 by Drayton, Ross M, Dudziec, Ewa, Peter, Stefan, Bertz, Simone, Hartmann, Arndt, Bryant, Helen E, Catto, James WF

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Abstract A10: MicroRNA 27a is downreguated in cisplatin resistant bladder cancer cells, and contributes to resistance through the targeting of xCT, a cystine transporter involved with glutathione production by Drayton, Ross M., Dudziec, Ewa, Catto, James W.F., Bryant, Helen E.

“…Abstract Cisplatin resistance represents a serious obstacle to the chemotherapeutic treatment of many tumors. The purpose of this study was to create a cell…”
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