Search Results - "Dray, Eloise"

Chromosome arm aneuploidies shape tumour evolution and drug response by Shukla, Ankit, Nguyen, Thu H. M., Moka, Sarat B., Ellis, Jonathan J., Grady, John P., Oey, Harald, Cristino, Alexandre S., Khanna, Kum Kum, Kroese, Dirk P., Krause, Lutz, Dray, Eloise, Fink, J. Lynn, Duijf, Pascal H. G.

“…Chromosome arm aneuploidies (CAAs) are pervasive in cancers. However, how they affect cancer development, prognosis and treatment remains largely unknown…”
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Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids by Muralimanoharan, Sribalasubashini, Shamby, Ross, Stansbury, Nicholas, Schenken, Robert, de la Pena Avalos, Barbara, Javanmardi, Samin, Dray, Eloise, Sung, Patrick, Boyer, Thomas G.

“…Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms…”
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MYB regulates the DNA damage response and components of the homology-directed repair pathway in human estrogen receptor-positive breast cancer cells by Yang, Ren-Ming, Nanayakkara, Devathri, Kalimutho, Murugan, Mitra, Partha, Khanna, Kum Kum, Dray, Eloise, Gonda, Thomas J.

“…Over 70% of human breast cancers are estrogen receptor-positive (ER + ), most of which express MYB . In these and other cell types, the MYB transcription…”
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Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma by Conway, Patrick J., De La Peña Avalos, Bárbara, Dao, Jonathan, Montagnino, Sebastian, Kovalskyy, Dmytro, Dray, Eloise, Mahadevan, Daruka

“…•Alisertib, an ATP site inhibitor of Aurora A kinase, induces cell cycle dysregulation and polyploidy in Diffuse Large B Cell Lymphoma.•The combination of…”
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Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress by Liao, Yiji, Chen, Chen-Hao, Xiao, Tengfei, de la Peña Avalos, Bárbara, Dray, Eloise V, Cai, Changmeng, Gao, Shuai, Shah, Neel, Zhang, Zhao, Feit, Avery, Xue, Pengya, Liu, Zhijie, Yang, Mei, Lee, Ji Hoon, Xu, Han, Li, Wei, Mei, Shenglin, Pierre, Roodolph S, Shu, Shaokun, Fei, Teng, Duarte, Melissa, Zhao, Jin, Bradner, James E, Polyak, Kornelia, Kantoff, Philip W, Long, Henry, Balk, Steven P, Liu, X Shirley, Brown, Myles, Xu, Kexin

“…Drugs that block the activity of the methyltransferase EZH2 are in clinical development for the treatment of non-Hodgkin lymphomas harboring EZH2…”
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Evolved histone tail regulates 53BP1 recruitment at damaged chromatin by Kelliher, Jessica L., Folkerts, Melissa L., Shen, Kaiyuan V., Song, Wan, Tengler, Kyle, Stiefel, Clara M., Lee, Seong-Ok, Dray, Eloise, Zhao, Weixing, Koss, Brian, Pannunzio, Nicholas R., Leung, Justin W.

“…The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged…”
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The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation by Nelson, Christopher B., Rogers, Samuel, Roychoudhury, Kaushik, Tan, Yaw Sing, Atkinson, Caroline J., Sobinoff, Alexander P., Tomlinson, Christopher G., Hsu, Anton, Lu, Robert, Dray, Eloise, Haber, Michelle, Fletcher, Jamie I., Cesare, Anthony J., Hegde, Rashmi S., Pickett, Hilda A.

“…The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To…”
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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage by Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropée, Romain, Patch, Ann-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen, Shu W., Day, Bryan, Möller, Andreas, Cloonan, Nicole, Pearson, John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E., Edwards, Stacey L., French, Juliet D.

“…Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a…”
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In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion by Thangavelu, Pulari U, Krenács, Tibor, Dray, Eloise, Duijf, Pascal H G

“…Metastasis is a leading cause of death among cancer patients. In the tumor microenvironment, altered levels of extracellular matrix proteins, such as…”
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The calcium pump plasma membrane Ca2+-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin by Peters, Amelia A., Milevskiy, Michael J. G., Lee, Wei C., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J., Monteith, Gregory R.

“…Regulation of Ca 2+ transport is vital in physiological processes, including lactation, proliferation and apoptosis. The plasmalemmal Ca 2+ pump isoform 2…”
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NR4A2 Promotes DNA Double-strand Break Repair Upon Exposure to UVR by Yin, Kelvin, Chhabra, Yash, Tropée, Romain, Lim, Yi Chieh, Fane, Mitchell, Dray, Eloise, Sturm, Richard A, Smith, Aaron G

“…Exposure of melanocytes to ultraviolet radiation (UVR) induces the formation of UV lesions that can produce deleterious effects in genomic DNA. Encounters of…”
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900 Depleting non-canonical, cell-intrinsic PD-L1 signals induces synthetic lethality to small molecule DNA damage response inhibitors in an immune independent and dependent manner by Kornepati, Anand, Murray, Clare, Avalos, Barbara, Rogers, Cody, Ramkumar, Kavya, Gupta, Harshita, Deng, Yilun, Liu, Zexuan, Padron, Alvaro, Vadlamudi, Ratna, Dray, Eloise, Zhao, Weixing, Sung, Patrick, Byers, Lauren, Curiel, Tyler

“…BackgroundTumor surface-expressed programmed death-ligand 1 (PD-L1) suppresses immunity when it engages programmed death-1 (PD-1) on anti-tumor immune cells in…”
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Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers by Janysek, Dawn C., Kim, Jennifer, Duijf, Pascal H.G., Dray, Eloïse

“…•In this review, we detail the cellular function of tumor suppressors essential in DNA damage repair pathways, which explain their tumor suppressor…”
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EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance by de la Peéa Avalos, Bárbara, Tropée, Romain, Duijf, Pascal H. G, Dray, Eloïse

“…Abstract The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases (PP), which have been linked to many vital…”
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Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination by Prakash, Rohit, Satory, Dominik, Dray, Eloïse, Papusha, Almas, Scheller, Jürgen, Kramer, Wilfried, Krejci, Lumir, Klein, Hannah, Haber, James E, Sung, Patrick, Ira, Grzegorz

“…Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that…”
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NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability by Parplys, Ann C, Zhao, Weixing, Sharma, Neelam, Groesser, Torsten, Liang, Fengshan, Maranon, David G, Leung, Stanley G, Grundt, Kirsten, Dray, Eloïse, Idate, Rupa, Østvold, Anne Carine, Schild, David, Sung, Patrick, Wiese, Claudia

“…NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) is a 27 kD chromosomal, vertebrate-specific protein, for which limited functional data…”
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The SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer by Tropée, Romain, de la Peña Avalos, Bárbara, Gough, Madeline, Snell, Cameron, Duijf, Pascal H. G., Dray, Eloïse

“…Purpose Chromatin remodeling plays an essential role in regulating transcriptional networks and timing of gene expression. Chromatin remodelers such as…”
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The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of tyrosine 315 on RAD51 by de la Peña Avalos, Bárbara, Paquet, Nicolas, Tropée, Romain, Coulombe, Yan, Palacios, Hannah, Leung, Justin W, Masson, Jean-Yves, Duijf, Pascal H G, Dray, Eloïse

“…Efficient DNA repair and limitation of genome rearrangements rely on crosstalk between different DNA double-strand break (DSB) repair pathways, and their…”
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Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 by Galkin, Vitold E, Etchin, Julia, Egelman, Edward, Yu, Xiong, Schild, David, Chen, Junjie, Wiese, Claudia, Williams, Gareth J, Sy, Shirley M-H, Sung, Patrick, Tsai, Miaw-Sheue, Dray, Eloïse, Saro, Dorina, Hammel, Michal, Liu, Dongqing

“…Tumor suppressor PALB2 is known to interact with BRCA1 and BRCA2, and to be required for the latter's localization to sites of DNA damage. Now PALB2 is shown…”
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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors by Murray, Clare E, Kornepati, Anand V R, Ontiveros, Carlos, Liao, Yiji, de la Peña Avalos, Bárbara, Rogers, Cody M, Liu, Zexuan, Deng, Yilun, Bai, Haiyan, Kari, Suresh, Padron, Alvaro S, Boyd, Jacob T, Reyes, Ryan, Clark, Curtis A, Svatek, Robert S, Li, Rong, Hu, Yanfen, Wang, Meiling, Conejo-Garcia, José R, Byers, Lauren A, Ramkumar, Kavya, Sood, Anil K, Lee, Jung-Min, Burd, Christin E, Vadlamudi, Ratna K, Gupta, Harshita B, Zhao, Weixing, Dray, Eloïse, Sung, Patrick, Curiel, Tyler J

“…Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical…”
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