Search Results - "Dray, Andy"

Arthritis and pain. Future targets to control osteoarthritis pain by Dray, Andy, Read, Simon J

“…Clinical presentation of osteoarthritis (OA) is dominated by pain during joint use and at rest. OA pain is caused by aberrant functioning of a pathologically…”
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New Horizons in Pharmacologic Treatment for Rheumatic Disease Pain by Dray, Andy, PhD

“…Chronic pain is the major concern for patients with rheumatic diseases, such as low back pain, osteoarthritis, and rheumatoid arthritis, but current therapies…”
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Osteoarthritic pain: a review of current, theoretical and emerging therapeutics by Read, Simon J, Dray, Andy

“…Despite exciting progress and growth in the understanding of molecular and cellular mechanisms of chronic pain, osteoarthritis (OA) pain remains a challenging…”
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Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs by Lembo, Paola M.C, Grazzini, Eric, Groblewski, Thierry, O'Donnell, Dajan, Roy, Marie-Odile, Zhang, Ji, Hoffert, Cyrla, Cao, Jack, Schmidt, Ralf, Pelletier, Manon, Labarre, Maryse, Gosselin, Mylene, Fortin, Yves, Banville, Denis, Shen, S.H, Ström, Peter, Payza, Kemal, Dray, Andy, Walker, Philippe, Ahmad, Sultan

“…Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proenkephalin A, and among these are a number of enkephalin…”
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Neuropharmacological mechanisms of capsaicin and related substances by Dray, A

“…Capsaicin activates poorly myelinated primary afferent neurons, many of which are polymodal nociceptors. Activation is accompanied by membrane depolarization…”
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Kinins and kinin receptors in the nervous system by Walker, Katharine, Perkins, Martin, Dray, Andy

“…Kinins, including bradykinin and kallidin, are peptides that are produced and act at the site of tissue injury or inflammation. They induce a variety of…”
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In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats by Fundytus, Marian E, Fisher, Kim, Dray, Andy, Henry, James L, Coderre, Terence J

“…TO examine the specific roles of group I metabotropic glutamate receptors (mGluRs) in nociceptive processing, we examined the effects of intrathecal (i.t.)…”
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Priming enhances endotoxin-induced thermal hyperalgesia and mechanical allodynia in rats by Cahill, Catherine M., Dray, Andy, Coderre, Terence J.

“…Central inflammation is an integral component and contributor of the pathology of many debilitating diseases and has been shown to produce spontaneous pain and…”
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Cobalt accumulation in neurons expressing ionotropic excitatory amino acid receptors in young rat spinal cord: morphology and distribution by Nagy, I, Woolf, C J, Dray, A, Urbán, L

“…Excitatory amino acids (EAA) acting on N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptors play…”
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Kinins and their receptors in hyperalgesia by Dray, A

“…Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising…”
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Bradykinin and inflammatory pain by Dray, A, Perkins, M

“…There is compelling evidence linking bradykinin (BK) with the pathophysiological processes that accompany tissue damage and inflammation, especially the…”
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Novel molecular targets in pain control by Dray, Andy

“…The complexity of pain processing in clinical pain conditions and in animal models has revealed many time-related changes and an abundance of molecular drug…”
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Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat by Perkins, Martin Nicholas, Campbell, Elizabeth, Dray, Andy

“…There has been recent evidence linking bradykinin (BK) receptors with inflammation. This study has investigated the involvement of BK receptors in two models…”
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Pharmacology of chronic pain by Dray, A, Urban, L, Dickenson, A

“…Chronic pain, which is associated with prolonged tissue damage or injuries to the peripheral or central nervous system, results from a number of complex…”
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Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain by Cahill, Catherine M, Dray, Andy, Coderre, Terence J

“…It is without dispute that the treatment of neuropathic pain is an area of largely unmet medical need. Available analgesics, such as morphine, either have…”
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Knockdown of spinal metabotropic glutamate receptor 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats by Fundytus, Marian E, Yashpal, Kiran, Chabot, Jean‐Guy, Osborne, Michael G, Lefebvre, Celeste D, Dray, Andy, Henry, James L, Coderre, Terence J

“…Nerve injury often produces long‐lasting spontaneous pain, hyperalgesia and allodynia that are refractory to treatment, being only partially relieved by…”
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A pro-nociceptive role of neuromedin U in adult mice by Cao, Chang Qing, Yu, Xiao Hong, Dray, Andy, Filosa, Angelo, Perkins, Martin N

“…Although the neuropeptide neuromedin U (NMU) was first isolated from the spinal cord, its actions in this site are unknown. The recent identification of the…”
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Antisense oligonucleotide knockdown of mGluR 1 alleviates hyperalgesia and allodynia associated with chronic inflammation by Fundytus, Marian E, Osborne, Michael G, Henry, James L, Coderre, Terence J, Dray, Andy

“…Chronic inflammation induced by injection of complete Freund's adjuvant (CFA) into one hindpaw elicits thermal hyperalgesia and mechanical allodynia in the…”
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Inflammation and hyperalgesia: highlighting the team effort by Dray, A, Bevan, S

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Enhanced thermal antinociceptive potency and anti-allodynic effects of morphine following spinal administration of endotoxin by Cahill, Catherine M., Dray, Andy, Coderre, Terence J.

“…Recently, an animal model of central inflammation characterized by widespread cutaneous hyperalgesia and allodynia following intracerebroventricular (i.c.v.)…”
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