Search Results - "Drastik, Martin"

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites by Kamaraj, Rajamanikkam, Drastik, Martin, Maixnerova, Jana, Pavek, Petr

“…The pregnane X receptor (PXR, ) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in…”
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Origin of heat-induced structural changes in dissolved organic matter by DRASTIK, Martin, NOVAK, František, KUCERIK, Jiří

“…► Reactivity of DOM strongly depends on its concentration. ► Different parts of total compressibility play role at different concentrations. ► Progressive…”
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(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells by Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Kronenberger, Thales, Micuda, Stanislav, Dracinsky, Martin, Klepetarova, Blanka, Kudova, Eva, Pavek, Petr

“…Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor…”
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Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain by Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr

“…The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown…”
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Filling the Blank Space: Branched 4‑Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol by Rashidian, Azam, Dušek, Jan, Drastik, Martin, Smutná, Lucie, Fritsche, Kristin, Braeuning, Albert, Pijnenburg, Dirk, van Beuningen, Rinie, Honkakoski, Paavo, Poso, Antti, Kronenberger, Thales, Pavek, Petr

“…4-Nonylphenol (4-NP), a para-substituted phenolic compound with a straight or branched carbon chain, is a ubiquitous environmental pollutant and food…”
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Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers by Snejdrova, Eva, Dittrich, Milan, Drastik, Martin

“…Three oligoesters with different molar mass and degree of branching, intended as drug carriers, were synthesized and their thermal, rheological, adhesive, and…”
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Mucoadhesive plasticized system of branched poly(lactic-co-glycolic acid) with aciclovir by Snejdrova, Eva, Drastik, Martin, Dittrich, Milan, Kastner, Petr, Nguyenova, Jana

“…Commercially available antibacterial semisolid preparations intended for topical application provide only short-term drug release. A sustained kinetics is…”
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Terbinafine-loaded branched PLGA-based cationic nanoparticles with modifiable properties by Martiska, Juraj, Snejdrova, Eva, Drastik, Martin, Matysova, Ludmila, Dittrich, Milan, Loskot, Jan, Jilek, Petr

“…Although the systemic administration of terbinafine is quite well tolerated, topical treatment of the local infections is often preferred. New formulation…”
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3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism by Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Holas, Ondrej, Hroch, Milos, Smutny, Tomas, Skoda, Josef, Hutníková, Miriama, Pandey, Amit V., Micuda, Stanislav, Kudova, Eva, Pavek, Petr

“…[Display omitted] •3β-IsoOCA is an efficient FXR activator due to epimerization to OCA in the hepatic cells.•3,7-DehydroOCA is a novel potent GPBAR1…”
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