Search Results - "Draper, Heather R"

Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies by Garcia-Prats, Anthony J, Schaaf, H Simon, Draper, Heather R, Garcia-Cremades, Maria, Winckler, Jana, Wiesner, Lubbe, Hesseling, Anneke C, Savic, Rada M

“…Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid…”
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Factors associated with linkage to HIV care and TB treatment at community-based HIV testing services in Cape Town, South Africa by Meehan, Sue-Ann, Sloot, Rosa, Draper, Heather R, Naidoo, Pren, Burger, Ronelle, Beyers, Nulda

“…Diagnosing HIV and/or TB is not sufficient; linkage to care and treatment is conditional to reduce the burden of disease. This study aimed to determine factors…”
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Tuberculosis Disease during Pregnancy and Treatment Outcomes in HIV-Infected and Uninfected Women at a Referral Hospital in Cape Town by Bekker, Adrie, Schaaf, Hendrik S, Draper, Heather R, Kriel, Magdalena, Hesseling, Anneke C

“…Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings. A prospective cohort study of…”
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Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial by Garcia-Prats, Anthony J, Svensson, Elin M, Winckler, Jana, Draper, Heather R, Fairlie, Lee, van der Laan, Louvina E, Masenya, Masebole, Schaaf, H Simon, Wiesner, Lubbe, Norman, Jennifer, Aarnoutse, Rob E, Karlsson, Mats O, Denti, Paolo, Hesseling, Anneke C

“…Abstract Background Rifampicin doses of 40 mg/kg in adults are safe and well tolerated, may shorten anti-TB treatment and improve outcomes, but have not been…”
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Pharmacokinetics and Safety of Moxifloxacin in Children With Multidrug-Resistant Tuberculosis by Thee, Stephanie, Garcia-Prats, Anthony J., Draper, Heather R., McIlleron, Helen M., Wiesner, Lubbe, Castel, Sandra, Schaaf, H. Simon, Hesseling, Anneke C.

“…Background. Moxifloxacin is currently recommended at a dose of 7.5–10 mg/kg for children with multidrug-resistant (MDR) tuberculosis, but pharmacokinetic and…”
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Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis by White, Yasmine N, Solans, Belen P, Denti, Paolo, van der Laan, Louvina E, Schaaf, H Simon, Vonasek, Bryan, Malik, Amyn A, Draper, Heather R, Hussain, Hamidah, Hesseling, Anneke C, Garcia-Prats, Anthony J, Savic, Radojka M

“…Abstract Background Each year 25 000–32 000 children develop rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB), and many more require preventive…”
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Moxifloxacin Pharmacokinetics, Cardiac Safety, and Dosing for the Treatment of Rifampicin-Resistant Tuberculosis in Children by Radtke, Kendra K, Hesseling, Anneke C, Winckler, J L, Draper, Heather R, Solans, Belen P, Thee, Stephanie, Wiesner, Lubbe, van der Laan, Louvina E, Fourie, Barend, Nielsen, James, Schaaf, H Simon, Savic, Radojka M, Garcia-Prats, Anthony J

“…Abstract Background Moxifloxacin is a recommended drug for rifampin-resistant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic…”
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Hepatocellular Injury in Children Treated for Rifampicin-resistant Tuberculosis: Incidence, Etiology and Outcome by Duvenhage, Joanie, Draper, Heather R., Garcia-Prats, Anthony J., Winckler, Jana, Hesseling, Anneke C., Schaaf, H. Simon

“…Hepatocellular injury has been reported commonly in adults on rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) treatment. However, there…”
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QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies by Ali, Ali Mohamed, Radtke, Kendra K, Hesseling, Anneke C, Winckler, Jana, Schaaf, H Simon, Draper, Heather R, Solans, Belén P, van der Laan, Louvina, Hughes, Jennifer, Fourie, Barend, Nielsen, James, Garcia-Prats, Anthony J, Savic, Rada M

“…Rifampicin-resistant tuberculosis (RR-TB) involves treatment with many drugs that can prolong the QT interval; this risk may increase when multiple…”
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Pharmacokinetics and optimized dosing of dispersible and non-dispersible levofloxacin formulations in young children by van der Laan, Louvina E, Hesseling, Anneke C, Schaaf, H Simon, Palmer, Megan, Draper, Heather R, Wiesner, Lubbe, Denti, Paolo, Garcia-Prats, Anthony J

“…Abstract Background Levofloxacin is used for treatment and prevention of rifampicin-resistant (RR)-TB in children. Recent data showed higher exposures with 100…”
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Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis by Ali, Ali Mohamed, P Solans, Belén, Hesseling, Anneke C, Winckler, Jana, Schaaf, H Simon, Draper, Heather R, van der Laan, Louvina, Hughes, Jennifer, Fourie, Barend, Nielsen, James, Wiesner, Lubbe, Garcia-Prats, Anthony J, Savic, Radojka M

“…Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in…”
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Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis by Denti, Paolo, Garcia-Prats, Anthony J, Draper, Heather R, Wiesner, Lubbe, Winckler, Jana, Thee, Stephanie, Dooley, Kelly E, Savic, Rada M, McIlleron, Helen M, Schaaf, H Simon, Hesseling, Anneke C

“…Levofloxacin is increasingly used in the treatment of multidrug-resistant tuberculosis (MDR-TB). There are limited pediatric pharmacokinetic data to inform…”
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Optimizing dosing of the cycloserine pro-drug terizidone in children with rifampicin-resistant tuberculosis by van der Laan, Louvina E, Garcia-Prats, Anthony J, McIlleron, Helen, Abdelwahab, Mahmoud T, Winckler, Jana L, Draper, Heather R, Wiesner, Lubbe, Schaaf, H Simon, Hesseling, Anneke C, Denti, Paolo

“…There are no pharmacokinetic data in children on terizidone, a pro-drug of cycloserine and a World Health Organization (WHO)-recommended group B drug for…”
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Pharmacokinetics, Safety, and Dosing of Novel Pediatric Levofloxacin Dispersible Tablets in Children with Multidrug-Resistant Tuberculosis Exposure by Garcia-Prats, Anthony J, Purchase, Susan E, Osman, Muhammad, Draper, Heather R, Schaaf, H Simon, Wiesner, Lubbe, Denti, Paolo, Hesseling, Anneke C

“…This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged <5 years who had household…”
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Erratum for van der Laan et al., "Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis" by van der Laan, Louvina E, Garcia-Prats, Anthony J, Schaaf, H Simon, Chirehwa, Maxwell, Winckler, Jana L, Mao, Jun, Draper, Heather R, Wiesner, Lubbe, Norman, Jennifer, McIlleron, Helen, Donald, Peter R, Hesseling, Anneke C, Denti, Paolo

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Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children by Walters, Elisabetta, Demers, Anne-Marie, van der Zalm, Marieke M, Whitelaw, Andrew, Palmer, Megan, Bosch, Corné, Draper, Heather R, Gie, Robert P, Hesseling, Anneke C

“…Bacteriological confirmation of is achieved in the minority of young children with tuberculosis (TB), since specimen collection is resource intensive and…”
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Pharmacokinetics and Safety of Bedaquiline in Human Immunodeficiency Virus (HIV)-Positive and Negative Older Children and Adolescents With Rifampicin-Resistant Tuberculosis by Hughes, Jennifer A, Solans, Belén P, Draper, Heather R, Schaaf, H Simon, Winckler, Jana L, van der Laan, Louvina, Radtke, Kendra K, Fourie, Barend, Wiesner, Lubbe, Hesseling, Anneke C, Savic, Radojka M, Garcia-Prats, Anthony J

“…Abstract Background Pharmacokinetic data for bedaquiline in children are limited. We described the pharmacokinetics and safety of bedaquiline in South African…”
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Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis by van der Laan, Louvina E, Garcia-Prats, Anthony J, Schaaf, H Simon, Chirehwa, Maxwell, Winckler, Jana L, Mao, Jun, Draper, Heather R, Wiesner, Lubbe, Norman, Jennifer, McIlleron, Helen, Donald, Peter R, Hesseling, Anneke C, Denti, Paolo

“…Treatment options for children with Rifampicin-resistant tuberculosis (RR-TB) remain limited, and para-aminosalicylic acid (PAS) is still a relevant component…”
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Specimen Pooling as a Diagnostic Strategy for Microbiologic Confirmation in Children with Intrathoracic Tuberculosis by Walters, Elisabetta, van der Zalm, Marieke M, Demers, Anne-Marie, Whitelaw, Andrew, Palmer, Megan, Bosch, Corné, Draper, Heather R, Schaaf, H Simon, Goussard, Pierre, Lombard, Carl J, Gie, Robert P, Hesseling, Anneke C

“…Three-hundred four young children with suspected pulmonary tuberculosis had a gastric aspirate, induced sputum and nasopharyngeal aspirate collected on each of…”
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Trends in Drug Resistance in Childhood Tuberculosis in Cape Town, South Africa by Schaaf, H Simon, Garcia-Prats, Anthony J, Draper, Heather R, Rautenbach, Corné, Bosch, Corné, Demers, Anne-Marie, Hesseling, Anneke C, Walters, Elisabetta

“…BACKGROUND:We determined mycobacterial drug resistance and HIV prevalence among children with bacteriologically confirmed tuberculosis (TB) from March 2013 to…”
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