Search Results - "Dransfield, I."

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells by Dransfield, I, Zagórska, A, Lew, E D, Michail, K, Lemke, G

“…Billions of inflammatory leukocytes die and are phagocytically cleared each day. This regular renewal facilitates the normal termination of inflammatory…”
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Functional and clinical consequences of Fc receptor polymorphic and copy number variants by Bournazos, S, Woof, J.M, Hart, S.P, Dransfield, I

“…Receptors for immunoglobulins (Fc receptors) play a central role during an immune response, as they mediate the specific recognition of antigens of almost…”
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N-Acetylcysteine inhibits platelet–monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial by Treweeke, A. T., Winterburn, T. J., Mackenzie, I., Barrett, F., Barr, C., Rushworth, G. F., Dransfield, I., MacRury, S. M., Megson, I. L.

“…Aims/hypothesis The aim of this study was to determine whether oral dosing with N -acetylcysteine (NAC) increases intraplatelet levels of the antioxidant,…”
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Phagocytosis of opsonized apoptotic cells: roles for ‘old‐fashioned’ receptors for antibody and complement by HART, S. P., SMITH, J. R., DRANSFIELD, I.

“…SUMMARY Efficient phagocytic clearance of apoptotic cells is crucial in many biological processes. A bewildering array of phagocyte receptors have been…”
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Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation by Heasman, SJ, Giles, KM, Ward, C, Rossi, AG, Haslett, C, Dransfield, I

“…Glucocorticoids represent one of the most effective clinical treatments for a range of inflammatory conditions, including severe acute inflammation. Although…”
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Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes by Hart, S P, Ross, J A, Ross, K, Haslett, C, Dransfield, I

“…We have used a panel of monoclonal antibodies and lectins to examine the profile of surface molecule expression on human neutrophils that have undergone…”
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Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac by Giles, Katherine M, Ross, Katherine, Rossi, Adriano G, Hotchin, Neil A, Haslett, Christopher, Dransfield, Ian

“…Phagocytic clearance of apoptotic granulocytes has a pivotal role in determining an inflammatory outcome, resolution or progression to a chronic state…”
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Granulocyte Apoptosis and the Control of Inflammation by Haslett, C., Savill, J. S., Whyte, M. K. B., Stern, M., Dransfield, I., Meagher, L. C.

“…We have described a novel pathway available for the clearance of extravasated granulocytes from inflamed tissues whereby aging granulocytes undergo apoptosis,…”
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Priming differentially regulates neutrophil adhesion molecule expression/function by CONDLIFFE, A. M., CHILVERS, E. R., HASLETT, C., DRANSFIELD, I.

“…Lung injury in a variety of disease states is critically dependent on neutrophil‐mediated inflammatory responses. Neutrophil recruitment to sites of infection…”
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Divalent Cation Regulation of the Function of the Leukocyte Integrin LFA-1 by Dransfield, Ian, Cabañas, Carlos, Craig, Alister, Hogg, Nancy

“…The integrin lymphocyte function-associated antigen-1 (LFA-1) expressed on T cells serves as a useful model for analysis of leukocyte integrin functional…”
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Neutrophils: dead or effete? Cell surface phenotype and implications for phagocytic clearance by Dransfield, I, Rossi, A G, Brown, S B, Hart, S P

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Granulocyte apoptosis: who would work with a 'real' inflammatory cell? by Dransfield, I, Rossi, A G

“…The neutrophil granulocyte is a key factor in cellular innate defence mechanisms against infection or tissue damage. Granulocyte apoptosis is now acknowledged…”
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Activation of human lung mast cells by monomeric immunoglobulin E by Hart, S P, Dransfield, I

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Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis by Rossi, A.G., Cousin, J.M., Dransfield, I., Lawson, M.F., Chilvers, E.R., Haslett, C.

“…Neutrophil apoptosis, determined after 20 h in culture using standard criteria and shedding of cell surface CD16 (FcγRIII), is dramatically inhibited, in a…”
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Divalent cation‐dependent and ‐independent augmentation of macrophage phagocytosis of apoptotic neutrophils by CD44 antibody by VIVERS, S., HEASMAN, S. J., HART, S. P., DRANSFIELD, I.

“…SUMMARY Phagocytosis of apoptotic neutrophils by macrophages is required for resolution of an inflammatory response. Removal of intact apoptotic neutrophils…”
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Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods by Rossi, A G, Ward, C, Dransfield, I

“…Human granulocytes clearly play an important role in host defence against invading organisms, however they have also been implicated in the pathogenesis and…”
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Thalidomide analogue CC‐3052 reduces HIV+ neutrophil apoptosis in vitro by Guckian, M., Dransfield, I., Hay, P., Dalgleish, A. G.

“…Thalidomide has significant immunomodulatory properties and has been used successfully in the treatment of oral ulcers and wasting in HIV patients. However,…”
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Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin by McCutcheon, Judith C., Hart, Simon P., Canning, Mary, Ross, Katherine, Humphries, Martin J, Dransfield, Ian

“…The potential for leukocyte‐mediated host tissue damage during resolution of inflammatory responses is influenced by the rate at which extravasated apoptotic…”
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CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion by Stocks, S C, Kerr, M A, Haslett, C, Dransfield, I

“…We have examined the role of CD66 in the modulation of neutrophil adhesion and effector function. Engagement of neutrophil CD66 with anti-carcinoembryonic…”
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A blast from the past: clearance of apoptotic cells regulates immune responses by Savill, John, Dransfield, Ian, Gregory, Chris, Haslett, Chris

“…Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes…”
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