Search Results - "Drake, Richard R"

Glycosylation and Cancer: Moving Glycomics to the Forefront by Drake, Richard R

“…There is a long research history of studying the function of glycosylation in relation to the development and progression of different types of cancer. The…”
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Applications and continued evolution of glycan imaging mass spectrometry by McDowell, Colin T., Lu, Xiaowei, Mehta, Anand S., Angel, Peggi M., Drake, Richard R.

“…Glycosylation is an important posttranslational modifier of proteins and lipid conjugates critical for the stability and function of these macromolecules…”
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MALDI imaging mass spectrometry profiling of N-glycans in formalin-fixed paraffin embedded clinical tissue blocks and tissue microarrays by Powers, Thomas W, Neely, Benjamin A, Shao, Yuan, Tang, Huiyuan, Troyer, Dean A, Mehta, Anand S, Haab, Brian B, Drake, Richard R

“…A recently developed matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) method to spatially profile the location and…”
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Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections by Clift, Cassandra L., Drake, Richard R., Mehta, Anand, Angel, Peggi M.

“…We report a multiplexed imaging mass spectrometry method which spatially localizes and selectively accesses the extracellular matrix on formalin-fixed…”
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New Enzymatic Approach to Distinguish Fucosylation Isomers of N‑Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry by West, Connor A, Liang, Hongyan, Drake, Richard R, Mehta, Anand S

“…Specific alterations in N-linked glycans, such as core fucosylation, are associated with many cancers and other disease states. Because of the many possible…”
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Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen–Defined Pancreatic Cancer Tissues by McDowell, Colin T., Klamer, Zachary, Hall, Johnathan, West, Connor A., Wisniewski, Luke, Powers, Thomas W., Angel, Peggi M., Mehta, Anand S., Lewin, David N., Haab, Brian B., Drake, Richard R.

“…The early detection of pancreatic ductal adenocarcinoma (PDAC) is a complex clinical obstacle yet is key to improving the overall likelihood of patient…”
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Mass Spectrometry Imaging of N‑Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization by Pace, Crystal L, Angel, Peggi M, Drake, Richard R, Muddiman, David C

“…N-Linked glycans are structurally diverse polysaccharides that represent significant biological relevance due to their involvement in disease progression and…”
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Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry Workflow for Spatial Profiling Analysis of N‑Linked Glycan Expression in Tissues by Powers, Thomas W., Jones, E. Ellen, Betesh, Lucy R., Romano, Patrick R., Gao, Peng, Copland, John A., Mehta, Anand S., Drake, Richard R.

“…A new matrix assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) method to spatially profile the location and distribution of multiple…”
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Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry by Angel, Peggi M, Comte-Walters, Susana, Ball, Lauren E, Talbot, Kacey, Mehta, Anand, Brockbank, Kelvin G.M, Drake, Richard R

“…Collagens and elastin form the fundamental framework of all tissues and organs, and their expression and post-translational processing are tightly regulated in…”
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N‑Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging by West, Connor A, Wang, Mengjun, Herrera, Harmin, Liang, Hongyan, Black, Alyson, Angel, Peggi M, Drake, Richard R, Mehta, Anand S

“…Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum…”
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Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse by Cheng, Joseph C, Bai, Aiping, Beckham, Thomas H, Marrison, S Tucker, Yount, Caroline L, Young, Katherine, Lu, Ping, Bartlett, Anne M, Wu, Bill X, Keane, Barry J, Armeson, Kent E, Marshall, David T, Keane, Thomas E, Smith, Michael T, Jones, E Ellen, Drake, Jr, Richard R, Bielawska, Alicja, Norris, James S, Liu, Xiang

“…Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of…”
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Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer by Kim, Yunee, Jeon, Jouhyun, Mejia, Salvador, Yao, Cindy Q, Ignatchenko, Vladimir, Nyalwidhe, Julius O, Gramolini, Anthony O, Lance, Raymond S, Troyer, Dean A, Drake, Richard R, Boutros, Paul C, Semmes, O. John, Kislinger, Thomas

“…Biomarkers are rapidly gaining importance in personalized medicine. Although numerous molecular signatures have been developed over the past decade, there is a…”
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Defining the human kidney N‐glycome in normal and cancer tissues using MALDI imaging mass spectrometry by Drake, Richard R., McDowell, Colin, West, Connor, David, Fred, Powers, Thomas W., Nowling, Tamara, Bruner, Evelyn, Mehta, Anand S., Angel, Peggi M., Marlow, Laura A., Tun, Han W., Copland, John A.

“…Clear‐cell renal cell carcinoma (ccRCC) presents challenges to clinical management because of late‐stage detection, treatment resistance, and frequent disease…”
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Rapid N‑Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow by Blaschke, Calvin R. K, Black, Alyson P, Mehta, Anand S, Angel, Peggi M, Drake, Richard R

“…Changes in the levels and compositions of N-glycans released from serum and plasma glycoproteins have been assessed in many diseases across many large clinical…”
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Linkage-Specific in Situ Sialic Acid Derivatization for N‑Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues by Holst, Stephanie, Heijs, Bram, de Haan, Noortje, van Zeijl, René J. M, Briaire-de Bruijn, Inge H, van Pelt, Gabi W, Mehta, Anand S, Angel, Peggy M, Mesker, Wilma E, Tollenaar, Rob A, Drake, Richard R, Bovée, Judith V. M. G, McDonnell, Liam A, Wuhrer, Manfred

“…Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging is a rapidly evolving field in which mass spectrometry techniques are applied…”
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A Novel Mass Spectrometry Platform for Multiplexed N‑Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N‑Glycan Imaging by Black, Alyson P, Liang, Hongyan, West, Connor A, Wang, Mengjun, Herrera, Harmin P, Haab, Brian B, Angel, Peggi M, Drake, Richard R, Mehta, Anand S

“…A new platform for N-glycoprotein analysis from serum that combines matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) workflows…”
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Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain by Rebelo, Ana Lúcia, Gubinelli, Francesco, Roost, Pauline, Jan, Caroline, Brouillet, Emmanuel, Van Camp, Nadja, Drake, Richard R, Saldova, Radka, Pandit, Abhay

“…Neuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A specific molecular…”
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The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo by Venant, Heather, Rahmaniyan, Mehrdad, Jones, E Ellen, Lu, Ping, Lilly, Michael B, Garrett-Mayer, Elizabeth, Drake, Richard R, Kraveka, Jacqueline M, Smith, Charles D, Voelkel-Johnson, Christina

“…Despite recent advances in the development of novel therapies against castration-resistant prostate cancer, the advanced form of the disease remains a major…”
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Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N‑Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids by Lu, Xiaowei, McDowell, Colin T., Blaschke, Calvin R. K., Liu, Liping, Grimsley, Grace, Wisniewski, Luke, Gao, ChongFeng, Mehta, Anand S., Haab, Brian B., Angel, Peggi M., Drake, Richard R.

“…Sialic acid isomers attached in either α2,3 or α2,6 linkage to glycan termini confer distinct chemical, biological, and pathological properties, but they…”
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An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry by Wallace, Elizabeth N., West, Connor A., McDowell, Colin T., Lu, Xiaowei, Bruner, Evelyn, Mehta, Anand S., Aoki-Kinoshita, Kiyoko F., Angel, Peggi M., Drake, Richard R.

“…N- glycosylation is an abundant post-translational modification of most cell-surface proteins. N- glycans play a crucial role in cellular functions like…”
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