Search Results - "Drake, Pascal M. W"

Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products by Menary, Jonathan, Hobbs, Matthew, Mesquita de Albuquerque, Sara, Pacho, Agata, Drake, Pascal M W, Prendiville, Alison, Ma, Julian K-C, Fuller, Sebastian S

“…Plant molecular farming (PMF) is a convenient and cost-effective way to produce high-value recombinant proteins that can be used in the production of a range…”
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The production of recombinant pharmaceutical proteins in plants by Ma, Julian K-C, Drake, Pascal M. W, Christou, Paul

“…Imagine a world in which any protein, either naturally occurring or designed by man, could be produced safely, inexpensively and in almost unlimited quantities…”
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Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus by Ibrahim, Ahmad E C, van Dolleweerd, Craig J, Drake, Pascal M W, Ma, Julian K-C

“…Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA…”
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Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco by Drake, Pascal M.W, Barbi, Tommaso, Sexton, Amy, McGowan, Edward, Stadlmann, Johannes, Navarre, Catherine, Paul, Matthew J, Ma, Julian K.-C

“…Rhizosecretion is an attractive technology for the production of recombinant proteins from transgenic plants. However, to date, yields of plant-derived…”
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Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery by Pepponi, Ilaria, Stylianou, Elena, van Dolleweerd, Craig, Diogo, Gil Reynolds, Paul, Matthew J, Drake, Pascal M W, Ma, Julian K-C, Reljic, Rajko

“…Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular…”
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Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG by Pepponi, Ilaria, Diogo, Gil R, Stylianou, Elena, van Dolleweerd, Craig J, Drake, Pascal M W, Paul, Matthew J, Sibley, Laura, Ma, Julian K-C, Reljic, Rajko

“…Progress with protein-based tuberculosis (TB) vaccines has been limited by poor availability of adjuvants suitable for human application. Here, we developed…”
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Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N by Drake, Pascal M. W, de Moraes Madeira, Luisa, Szeto, Tim H, Ma, Julian K-C

“…The marshmallow plant (Althaea officinalis L.) has been used for centuries in medicine and other applications. Valuable secondary metabolites have previously…”
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Highly Immunogenic and Protective Recombinant Vaccine Candidate Expressed in Transgenic Plants by CHARGELEGUE, Daniel, DRAKE, Pascal M. W, OBREGON, Patricia, PRADA, Alessandra, FAIRWEATHER, Neil, MA, Julian K-C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Optimisation of contained Nicotiana tabacum cultivation for the production of recombinant protein pharmaceuticals by Colgan, Richard, Atkinson, Christopher J, Paul, Matthew, Hassan, Sally, Drake, Pascal M. W, Sexton, Amy L, Santa-Cruz, Simon, James, David, Hamp, Keith, Gutteridge, Colin, Ma, Julian K-C

“…Nicotiana tabacum is emerging as a crop of choice for production of recombinant protein pharmaceuticals. Although there is significant commercial expertise in…”
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Rational design and expression of a recombinant plant rhabdovirus glycoprotein for production of immunoreactive murine anti-sera by Ibrahim, Ahmad E.C., Reljic, Rajko, Drake Pascal, M.W., Ma, Julian K-C.

“…Lettuce necrotic yellows virus (LNYV) is a plant rhabdovirus which has a type-1 transmembrane glycoprotein. Here, we describe the generation of murine…”
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Mucosal Therapy of Multi-Drug Resistant Tuberculosis With IgA and Interferon-γ by Tran, Andy C, Diogo, Gil R, Paul, Matthew J, Copland, Alastair, Hart, Peter, Mehta, Nickita, Irvine, Edward B, Mussá, Tufária, Drake, Pascal M W, Ivanyi, Juraj, Alter, Galit, Reljic, Rajko

“…New evidence has been emerging that antibodies can be protective in various experimental models of tuberculosis. Here, we report on protection against…”
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Recombinant biologic products versus nutraceuticals from plants – a regulatory choice? by Drake, Pascal M. W., Szeto, Tim H., Paul, Mathew J., Teh, Audrey Y.‐H., Ma, Julian K‐C.

“…Biotechnology has transformed the potential for plants to be a manufacturing source of pharmaceutical compounds. Now, with transgenic and transient expression…”
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Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR by Drake, Pascal M.W, Barbi, Tommaso, Drever, Matthew R, van Dolleweerd, Craig J, Porter, Andrew J.R, Ma, Julian K.-C

“…We describe the engineering, regeneration, and characterization of transgenic tobacco plants expressing a recombinant antibody specific to microcystin-LR…”
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Genetically modified plants and human health by Key, Suzie, Ma, Julian K-C, Drake, Pascal MW

“…Summary Genetically modified (or GM) plants have attracted a large amount of media attention in recent years and continue to do so. Despite this, the general…”
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Generation of transgenic plants expressing plasma membrane-bound antibodies to the environmental pollutant microcystin-LR by Barbi, Tommaso, Drake, Pascal M. W, Drever, Matthew, van Dolleweerd, Craig J, Porter, Andrew R, Ma, Julian K-C

“…In this paper we describe the engineering and regeneration of transgenic tobacco plants expressing a recombinant plasma membrane-retained antibody specific to…”
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High‐yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures by Madeira, Luisa M, Szeto, Tim H, Henquet, Maurice, Raven, Nicole, Runions, John, Huddleston, Jon, Garrard, Ian, Drake, Pascal M.W, Ma, Julian K‐C

“…Rhizosecretion of recombinant pharmaceuticals from in vitro hydroponic transgenic plant cultures is a simple, low cost, reproducible and controllable…”
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Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing by Madeira, Luisa M., Szeto, Tim H., Ma, Julian K-C., Drake, Pascal M.W.

“…Rhizosecretion has many advantages for the production of recombinant pharmaceuticals, notably facile downstream processing from hydroponic medium. The aim of…”
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Molecular farming, patents and access to medicines by Drake, Pascal M W, Thangaraj, Harry

“…Transgenic plants have several advantages over other expression systems for the production of recombinant medicines, including low costs, large-scale…”
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Transgenic plants expressing antibodies: a model for phytoremediation by Drake, Pascal M. W., Chargelegue, Daniel, Vine, Nicholas D., Dolleweerd, Craig J., Obregon, Patricia, Ma, Julian K.‐C.

“…ABSTRACT The feasibility of using antibody expressing transgenic plants either to neutralize bioactive molecules in the rhizosphere, or to accumulate and…”
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HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production by Obregon, Patricia, Chargelegue, Daniel, Drake, Pascal M W, Prada, Alessandra, Nuttall, James, Frigerio, Lorenzo, Ma, Julian K-C

“…We describe the engineering of a human immunodeficiency virus-1 (HIV-1) p24-immunoglobulin A (IgA) antigen-antibody fusion molecule for therapeutic purposes…”
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