Search Results - "Drake, Kenneth L"

Systems Analysis of Early Host Gene Expression Provides Clues for Transient Mycobacterium avium ssp avium vs. Persistent Mycobacterium avium ssp paratuberculosis Intestinal Infections by Khare, Sangeeta, Drake, Kenneth L, Lawhon, Sara D, Nunes, Jairo E S, Figueiredo, Josely F, Rossetti, Carlos A, Gull, Tamara, Everts, Robin E, Lewin, Harris A, Adams, Leslie Garry

“…It has long been a quest in ruminants to understand how two very similar mycobacterial species, Mycobacterium avium ssp. paratuberculosis (MAP) and…”
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Correlative Gene Expression to Protective Seroconversion in Rift Valley Fever Vaccinates by Laughlin, Richard C, Drake, Kenneth L, Morrill, John C, Adams, L Garry

“…Rift Valley fever Virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease, Rift Valley fever (RVF). In both…”
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Systems Biology Analysis of Temporal In vivo Brucella melitensis and Bovine Transcriptomes Predicts host:Pathogen Protein-Protein Interactions by Rossetti, Carlos A, Drake, Kenneth L, Lawhon, Sara D, Nunes, Jairo S, Gull, Tamara, Khare, Sangeeta, Adams, Leslie G

“…To date, fewer than 200 gene-products have been identified as virulence factors, and most were characterized individually without considering how they are…”
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Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance by Khare, Sangeeta, Lawhon, Sara D, Drake, Kenneth L, Nunes, Jairo E S, Figueiredo, Josely F, Rossetti, Carlos A, Gull, Tamara, Everts, Robin E, Lewin, Harris A, Galindo, Cristi L, Garner, Harold R, Adams, Leslie Garry

“…Survival and persistence of Mycobacterium avium subsp. paratuberculosis (MAP) in the intestinal mucosa is associated with host immune tolerance. However, the…”
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Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome by Rossetti, Carlos A, Drake, Kenneth L, Siddavatam, Prasad, Lawhon, Sara D, Nunes, Jairo E S, Gull, Tamara, Khare, Sangeeta, Everts, Robin E, Lewin, Harris A, Adams, Leslie Garry

“…Brucella melitensis causes the most severe and acute symptoms of all Brucella species in human beings and infects hosts primarily through the oral route. The…”
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Correction: Correlative Gene Expression to Protective Seroconversion In Rift Valley Vaccinates by Laughin, Richard C, Drake, Kenneth L, Morrill, John C, Adams, L Garry

“…[This corrects the article DOI: 10.1371/journal.pone.0147027.]…”
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Brucella melitensis VjbR and C12-HSL regulons: contributions of the N-dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression by Weeks, Jenni N, Galindo, Cristi L, Drake, Kenneth L, Adams, Garry L, Garner, Harold R, Ficht, Thomas A

“…Quorum sensing is a communication system that regulates gene expression in response to population density and often regulates virulence determinants. Deletion…”
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Role of SPI-1 secreted effectors in acute bovine response to Salmonella enterica Serovar Typhimurium: a systems biology analysis approach by Lawhon, Sara D, Khare, Sangeeta, Rossetti, Carlos A, Everts, Robin E, Galindo, Cristi L, Luciano, Sarah A, Figueiredo, Josely F, Nunes, Jairo E S, Gull, Tamara, Davidson, George S, Drake, Kenneth L, Garner, Harold R, Lewin, Harris A, Bäumler, Andreas J, Adams, Leslie Garry

“…Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis with diarrhea and polymorphonuclear cell (PMN) influx into the intestinal mucosa…”
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Responses of intestinal virome to silver nanoparticles: safety assessment by classical virology, whole-genome sequencing and bioinformatics approaches by Gokulan, Kuppan, Bekele, Aschalew Z, Drake, Kenneth L, Khare, Sangeeta

“…Effects of silver nanoparticles (AgNP) on the intestinal virome/phage community are mostly unknown. The working hypothesis of this study was that the exposure…”
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Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses by Hanna, Nabil, Ouahrani-Bettache, Safia, Drake, Kenneth L, Adams, L Garry, Köhler, Stephan, Occhialini, Alessandra

“…In the intracellular pathogen Brucella spp., the activation of the stringent response, a global regulatory network providing rapid adaptation to…”
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Transcriptome analysis of HeLa cells response to Brucella melitensis infection: a molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis by Rossetti, Carlos A., Drake, Kenneth L., Adams, L. Garry

“…Brucella spp. infect hosts primarily by adhering and penetrating mucosal surfaces, however the initial molecular phenomena of this host:pathogen interaction…”
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Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: Linking systems biology with vaccine development by Adams, L. Garry, Khare, Sangeeta, Lawhon, Sara D, Rossetti, Carlos A, Lewin, Harris A, Lipton, Mary S, Turse, Joshua E, Wylie, Dennis C, Bai, Yu, Drake, Kenneth L

“…Highlights ► We analyzed in vivo gene expression data from both the bovine host and the zoonotic bacterial pathogens. ► We developed computational systems…”
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Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B. melitensis, S. enterica Typhimurium and M. avium paratuberculosis by Adams, L Garry, Khare, Sangeeta, Lawhon, Sara D, Rossetti, Carlos A, Lewin, Harris A, Lipton, Mary S, Turse, Joshua E, Wylie, Dennis C, Bai, Yu, Drake, Kenneth L

“…Background: To decipher the complexity and improve the understanding of host-pathogen interactions, biologists must adopt new system level approaches in which…”
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Global Rsh-dependent transcription profile of Brucella suisduring stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses by Hanna, Nabil, Ouahrani-Bettache, Safia, Drake, Kenneth L, Adams, L Garry, Köhler, Stephan, Occhialini, Alessandra

“…Abstract Background In the intracellular pathogen Brucella spp., the activation of the stringent response, a global regulatory network providing rapid…”
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Solid-State Electrodes for Multichannel Multiplexed Intracortical Neuronal Recording by BeMent, Spencer L., Wise, Kensall D., Anderson, David J., Najafi, Khalil, Drake, Kenneth L.

“…Thin-film arrays of extracellular recording electrodes have been developed for use in studies of information processing in neural structures and eventual use…”
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Correlative Gene Expression to Protective Seroconversion in Rift Valley Fever Vaccinates: e0147027 by Laughlin, Richard C, Drake, Kenneth L, Morrill, John C, Adams, L Garry

“…Rift Valley fever Virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease, Rift Valley fever (RVF). In both…”
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Brucella melitensis VjbR and C.sub.12 -HSL regulons: contributions of the N -dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression by Weeks, Jenni N, Galindo, Cristi L, Drake, Kenneth L, Adams, Garry L, Garner, Harold R, Ficht, Thomas A

“…Quorum sensing is a communication system that regulates gene expression in response to population density and often regulates virulence determinants. Deletion…”
Get full text

Brucella melitensis VjbR and C sub(12)-HSL regulons: contributions of the N-dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression by Weeks, Jenni N, Galindo, Cristi L, Drake, Kenneth L, Adams, Garry L, Garner, Harold R, Ficht, Thomas A

“…Background: Quorum sensing is a communication system that regulates gene expression in response to population density and often regulates virulence…”
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Systems Biology Analysis of Brucella Infected Peyer's Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome: e81719 by Rossetti, Carlos A, Drake, Kenneth L, Siddavatam, Prasad, Lawhon, Sara D, Nunes, Jairo ES, Gull, Tamara, Khare, Sangeeta, Everts, Robin E, Lewin, Harris A, Adams, Leslie Garry

“…Brucella melitensis causes the most severe and acute symptoms of all Brucella species in human beings and infects hosts primarily through the oral route. The…”
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Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis by Adams, L Garry, Khare, Sangeeta, Lawhon, Sara D, Rossetti, Carlos A, Lewin, Harris A, Lipton, Mary S, Turse, Joshua E, Wylie, Dennis C, Bai, Yu, Drake, Kenneth L

“…To decipher the complexity and improve the understanding of host-pathogen interactions, biologists must adopt new system level approaches in which the…”
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