Search Results - "Drake, Joshua"

Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing by Drake, Joshua C., Yan, Zhen

“…Skeletal muscle is important for overall functionality and health. Ageing is associated with an accumulation of damage to mitochondrial DNA and proteins. In…”
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Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle by Drake, Joshua C., Wilson, Rebecca J., Yan, Zhen

“…ABSTRACT Exercise training enhances physical performance and confers health benefits, largely through adaptations in skeletal muscle. Mitochondrial adaptation,…”
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Exercise-Induced Mitophagy in Skeletal Muscle and Heart by Guan, Yuntian, Drake, Joshua C, Yan, Zhen

“…Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An…”
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Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy by Laker, Rhianna C., Drake, Joshua C., Wilson, Rebecca J., Lira, Vitor A., Lewellen, Bevan M., Ryall, Karen A., Fisher, Carleigh C., Zhang, Mei, Saucerman, Jeffrey J., Goodyear, Laurie J., Kundu, Mondira, Yan, Zhen

“…Mitochondrial health is critical for skeletal muscle function and is improved by exercise training through both mitochondrial biogenesis and removal of…”
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Early-stage Alzheimer's disease: are skeletal muscle and exercise the key? by Brisendine, Matthew H, Drake, Joshua C

“…Alzheimer's disease (AD) is the most common form of dementia affecting approximately 6.5 million people in the United States alone. The development of AD…”
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Unclogging the garbage disposal: how exercise may improve mitochondria in ageing skeletal muscle by Drake, Joshua C.

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Ulk1 phosphorylation at S555 is not required for endurance training-induced improvements in exercise and metabolic capacity in mice by Guan, Yuntian, Spaulding, Hannah, Yu, Qing, Zhang, Mei, Willoughby, Orion, Drake, Joshua C, Yan, Zhen

“…Endurance exercise training improves exercise capacity as well as skeletal muscle and whole body metabolism, which are hallmarks of high quality-of-life and…”
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Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy by Drake, Joshua C., Wilson, Rebecca J., Laker, Rhianna C., Guan, Yuntian, Spaulding, Hannah R., Nichenko, Anna S., Shen, Wenqing, Shang, Huayu, Dorn, Maya V., Huang, Kian, Zhang, Mei, Bandara, Aloka B., Brisendine, Matthew H., Kashatus, Jennifer A., Sharma, Poonam R., Young, Alexander, Gautam, Jitendra, Cao, Ruofan, Wallrabe, Horst, Chang, Paul A., Wong, Michael, Desjardins, Eric M., Hawley, Simon A., Christ, George J., Kashatus, David F., Miller, Clint L., Wolf, Matthew J., Periasamy, Ammasi, Steinberg, Gregory R., Hardie, D. Grahame, Yan, Zhen

“…Mitochondria form a complex, interconnected reticulum that is maintained through coordination among biogenesis, dynamic fission, and fusion and mitophagy,…”
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A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway by Cui, Di, Drake, Joshua C., Wilson, Rebecca J., Shute, Robert J., Lewellen, Bevan, Zhang, Mei, Zhao, Henan, Sabik, Olivia L., Onengut, Suna, Berr, Stuart S., Rich, Stephen S., Farber, Charles R., Yan, Zhen

“…Our understanding of the molecular mechanisms underlying adaptations to resistance exercise remains elusive despite the significant biological and clinical…”
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Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria by Drake, Joshua C., Laker, Rhianna C., Wilson, Rebecca J., Zhang, Mei, Yan, Zhen

“…Maintenance of mitochondrial quality is essential for skeletal muscle function and overall health. Exercise training elicits profound adaptations to…”
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Interplay of ROS, mitochondrial quality, and exercise in aging: Potential role of spatially discrete signaling by Craige, Siobhan M., Mammel, Rebecca K., Amiri, Niloufar, Willoughby, Orion S., Drake, Joshua C.

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Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway by Keller, Alexander S, Diederich, Lukas, Panknin, Christina, DeLalio, Leon J, Drake, Joshua C, Sherman, Robyn, Jackson, Edwin Kerry, Yan, Zhen, Kelm, Malte, Cortese-Krott, Miriam M, Isakson, Brant E

“…Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In…”
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Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics by Bandara, Aloka B., Drake, Joshua C., James, Carissa C., Smyth, James W., Brown, David A.

“…Complex I is the largest and most intricate of the protein complexes of mitochondrial electron transport chain (ETC). This L-shaped enzyme consists of a…”
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AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures by Salvati, Kathryn A, Ritger, Matthew L, Davoudian, Pasha A, O'Dell, Finnegan, Wyskiel, Daniel R, Souza, George M P R, Lu, Adam C, Perez-Reyes, Edward, Drake, Joshua C, Yan, Zhen, Beenhakker, Mark P

“…Metabolism regulates neuronal activity and modulates the occurrence of epileptic seizures. Here, using two rodent models of absence epilepsy, we show that…”
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Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models by Miller, Benjamin F., Peelor, Frederick F., Biela, Laurie M., Drake, Joshua C., Bruns, Danielle R., Hamilton, Karyn L.

“…Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent…”
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Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog by Bandara, Aloka B, Drake, Joshua C, Brown, David A

“…Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and…”
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Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy by Wilson, Rebecca J, Drake, Joshua C, Cui, Di, Zhang, Mei, Perry, Heather M, Kashatus, Jennifer A, Kusminski, Christine M, Scherer, Philipp E, Kashatus, David F, Okusa, Mark D, Yan, Zhen

“…Assessment of structural and functional changes of mitochondria is vital for biomedical research as mitochondria are the power plants essential for biological…”
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Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle by Drake, Joshua C, Wilson, Rebecca J, Cui, Di, Guan, Yuntian, Kundu, Mondira, Zhang, Mei, Yan, Zhen

“…Unc51 like autophagy activating kinase 1 (Ulk1), the primary autophagy regulator, has been linked to metabolic adaptation in skeletal muscle to exercise…”
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Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice by Wilson, Rebecca J, Drake, Joshua C, Cui, Di, Ritger, Matthew L, Guan, Yuntian, Call, Jarrod A, Zhang, Mei, Leitner, Lucia M, Gödecke, Axel, Yan, Zhen

“…Ischemia-reperfusion (IR) due to temporary restriction of blood flow causes tissue/organ damages under various disease conditions, including stroke, myocardial…”
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Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice by Zhao, Henan, Lewellen, Bevan M., Wilson, Rebecca J., Cui, Di, Drake, Joshua C., Zhang, Mei, Yan, Zhen

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