Search Results - "Drake, Fred H."

Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption by Dodds, Robert A., James, Ian E., Rieman, David, Ahern, Reina, Hwang, Shing Mei, Connor, Janice R., Thompson, Scott D., Veber, Daniel F., Drake, Fred H., Holmes, Stephen, Lark, Michael W., Gowen, Maxine

“…Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast‐mediated bone resorption. We…”
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Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration by Rosengren, Sanna, Dychter, Samuel S., Printz, Marie A., Huang, Lei, Schiff, Richard I., Schwarz, Hans-Peter, McVey, John K., Drake, Fred H., Maneval, Dan C., Kennard, Don A., Frost, Gregory I., Sugarman, Barry J., Muchmore, Douglas B.

“…Recombinant human PH20 hyaluronidase (rHuPH20) is used to facilitate dispersion of subcutaneously delivered fluids and drugs. This report summarizes rHuPH20…”
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The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases by Garnero, Patrick, Borel, Olivier, Byrjalsen, Inger, Ferreras, Mercedes, Drake, Fred H., McQueney, Michael S., Foged, Niels T., Delmas, Pierre D., Delaissé, Jean-Marie

“…Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this collagen is a major event during bone resorption, but its…”
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The new partnership of genomics and chemistry for accelerated drug development by Veber, Daniel F, Drake, Fred H, Gowen, Maxine

“…Genomics and combinatorial chemistry are two methods that are revolutionizing drug discovery efforts. Analysis of gene sequences allows identification of novel…”
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Erratum to: Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration by Rosengren, Sanna, Dychter, Samuel S., Printz, Marie A., Huang, Lei, Schiff, Richard I., Schwarz, Hans-Peter, McVey, John K., Drake, Fred H., Maneval, Dan C., Kennard, Don A., Frost, Gregory I., Sugarman, Barry J., Muchmore, Douglas B.

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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (∗) by Drake, Fred H., Dodds, Robert A., James, Ian E., Connor, Janice R., Debouck, Christine, Richardson, Susan, Lee-Rykaczewski, Elizabeth, Coleman, Lindsay, Rieman, David, Barthlow, Ray, Hastings, Gregg, Gowen, Maxine

“…Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained,…”
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Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous infusions of large volumes of immunoglobulin in a swine model by Kang, David W., Jadin, Laurence, Nekoroski, Tara, Drake, Fred H., Zepeda, Monica L.

“…Many patients with primary immunodeficiency disease (PIDD) require lifelong immunoglobulin (Ig) replacement therapy. Home-based subcutaneous (SC) infusion…”
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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo by Votta, Bartholomew J., Levy, Mark A., Badger, Alison, Bradbeer, Jeremy, Dodds, Robert A., James, Ian E., Thompson, Scott, Bossard, Mary J., Carr, Thomas, Connor, Janice R., Tomaszek, Thaddeus A., Szewczuk, Lawrence, Drake, Fred H., Veber, Daniel F., Gowen, Maxine

“…We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in…”
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Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II by Drake, Fred H, Hofmann, Glenn A, Bartus, Henry F, Mattern, Michael R, Crooke, Stanley T, Mirabelli, Christopher K

“…The p170 and p180 forms of topoisomerase II have been compared. The concentration dependence of ATP for catalytic activity of the two forms of the enzyme was…”
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Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II .beta. isoform by Harker, W. Graydon, Slade, D. Lynn, Drake, Fred H, Parr, Ryan L

“…Mitoxantrone-resistant variants of the human HL-60 leukemia cell line are cross-resistant to several natural product and synthetic antineoplastic agents. The…”
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Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis by Lark, M W, Stroup, G B, Hwang, S M, James, I E, Rieman, D J, Drake, F H, Bradbeer, J N, Mathur, A, Erhard, K F, Newlander, K A, Ross, S T, Salyers, K L, Smith, B R, Miller, W H, Huffman, W F, Gowen, M

“…The Arg-Gly-Asp (RGD)-binding integrin alpha(V)beta(3) is highly expressed on osteoclasts and has been proposed to mediate cell-matrix adhesion required for…”
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In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone by DRAKE, F. H, HOFMANN, G. A, SHAU-MING MONG, O'LEARY BARTUS, J, HERTZBERG, R. P, JOHNSON, R. K, MATTERN, M. R, MIRABELLI, C. K

“…Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer et al., Biochem. Pharmacol.,…”
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Localization of DNA topoisomerase II in Chinese hamster fibroblasts by confocal and electron microscopy by Petrov, P, Drake, F H, Loranger, A, Huang, W, Hancock, R

“…The localization of the 170- and the 180-kDa isoforms of the enzyme DNA topoisomerase II in growing Chinese hamster fibroblasts has been studied by confocal…”
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Proteolytic Activity of Human Osteoclast Cathepsin K by Bossard, Mary J., Tomaszek, Thaddeus A., Thompson, Scott K., Amegadzie, Bernard Y., Hanning, Charles R., Jones, Christopher, Kurdyla, Jeff T., McNulty, Dean E., Drake, Fred H., Gowen, Maxine, Levy, Mark A.

“…Human cathepsin K is a recently identified protein with high primary sequence homology to members of the papain cysteine protease superfamily including…”
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Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification by Bossard, M J, Tomaszek, T A, Thompson, S K, Amegadzie, B Y, Hanning, C R, Jones, C, Kurdyla, J T, McNulty, D E, Drake, F H, Gowen, M, Levy, M A

“…Human cathepsin K is a recently identified protein with high primary sequence homology to members of the papain cysteine protease superfamily including…”
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Design of Potent and Selective Human Cathepsin K Inhibitors that Span the Active Site by Thompson, S K, Halbert, S M, Bossard, M J, Tomaszek, T A, Levy, M A, Zhao, B, Smith, W W, Abdel-Meguid, S S, Janson, C A, D'Alessio, K J, McQueney, M S, Amegadzie, B Y, Hanning, C R, DesJarlais, R L, Briand, J, Sarkar, S K, Huddleston, M J, Ijames, C F, Carr, S A, Garnes, K T, Shu, A, Heys, J R, Bradbeer, J, Zembryki, D, Lee-Rykaczewski, L, James, I E, Lark, M W, Drake, F H, Gowen, M, Gleason, J G, Veber, D F

“…Potent and selective active-site-spanning inhibitors have been designed for cathepsin K, a cysteine protease unique to osteoclasts. They act by mechanisms that…”
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DNA Topoisomerase IIα is the Major Chromosome Protein Recognized by the Mitotic Phosphoprotein Antibody MPM-2 by Taagepera, Salme, Rao, Potu N., Drake, Fred H., Gorbsky, Gary J.

“…We have determined that the major mitotic phosphoprotein in chromosomes recognized by the anti-phosphoprotein antibody MPM-2 is the 170-kDa isoform of…”
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Characterization and Immunological Identification of cDNA Clones Encoding Two Human DNA Topoisomerase II Isozymes by Thomas D. Y. Chung, Drake, Fred H., Tan, K. B., Per, Steven R., Crooke, Stanley T., Mirabelli, Christopher K.

“…Several DNA topoisomerase II (Topo II; EC 5.99.1.3) partial cDNA clones obtained from a human Raji-HN2 cDNA library were sequenced and two classes of…”
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Probably, but More Information Is Forthcoming by Votta, Bartholomew J., Drake, Fred H., Gowen, Maxine

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Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model by Miller, William H., Bondinell, William E., Cousins, Russell D., Erhard, Karl F., Jakas, Dalia R., Keenan, Richard M., Ku, Thomas W., Newlander, Kenneth A., Ross, Stephen T., Haltiwanger, R.Curtis, Bradbeer, Jeremy, Drake, Fred H., Gowen, Maxine, Hoffman, Sandra J., Hwang, Shing-Mei, James, Ian E., Lark, Michael W., Lechowska, Beata, Rieman, David J., Stroup, George B., Vasko-Moser, Janice A., Zembryki, Denise L., Azzarano, Leonard M., Adams, Paula C., Salyers, Kevin L., Smith, Brian R., Ward, Keith W., Johanson, Kyung O., Huffaman, William F.

“…A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this…”
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