Search Results - "Drake, Amanda J."

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk by Drake, Amanda J, Reynolds, Rebecca M

“…The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child,…”
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Non-genetic inheritance via the male germline in mammals by Baxter, Faye A, Drake, Amanda J

“…Numerous studies in humans and in animal models have demonstrated that exposure to adverse environmental conditions in early life results in long-term…”
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Glucocorticoids as mediators of developmental programming effects by Khulan, Batbayar, PhD, Drake, Amanda J., MBBS, PhD

“…Epidemiological evidence suggests that exposure to an adverse environment in early life is associated with an increased risk of cardio-metabolic and behavioral…”
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DNA methylation and brain structure and function across the life course: A systematic review by Wheater, Emily N.W., Stoye, David Q., Cox, Simon R., Wardlaw, Joanna M., Drake, Amanda J., Bastin, Mark E., Boardman, James P.

“…•60 studies of association between DNAm and human brain MRI were identified.•Differential DNAm is associated with brain structure and function throughout…”
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Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides by Weir, Graeme, Ramage, Lynne E., Akyol, Murat, Rhodes, Jonathan K., Kyle, Catriona J., Fletcher, Alison M., Craven, Thomas H., Wakelin, Sonia J., Drake, Amanda J., Gregoriades, Maria-Lena, Ashton, Ceri, Weir, Nick, van Beek, Edwin J.R., Karpe, Fredrik, Walker, Brian R., Stimson, Roland H.

“…Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by a reliance on positron emission tomography (PET)/computed tomography…”
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Intergenerational transmission of programmed effects: public health consequences by Drake, Amanda J, Liu, Lincoln

“…Epidemiological studies have shown that the environment experienced in early life can ‘programme’ susceptibility to later disease. Furthermore, there is…”
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Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial by Chiswick, Carolyn, MBChB, Reynolds, Rebecca M, Prof, Denison, Fiona, MD, Drake, Amanda J, PhD, Forbes, Shareen, PhD, Newby, David E, Prof, Walker, Brian R, Prof, Quenby, Siobhan, Prof, Wray, Susan, Prof, Weeks, Andrew, Prof, Lashen, Hany, MD, Rodriguez, Aryelly, MSc, Murray, Gordon, Prof, Whyte, Sonia, MSc, Norman, Jane E, Prof

“…Summary Background Maternal obesity is associated with increased birthweight, and obesity and premature mortality in adult offspring. The mechanism by which…”
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Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2 by Fitzgerald, Eamon, Roberts, Jennie, Tennant, Daniel A., Boardman, James P., Drake, Amanda J.

“…Neonatal encephalopathy due to hypoxia–ischemia is associated with adverse neurodevelopmental effects. The involvement of branched chain amino acids (BCAAs) in…”
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Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease by Drake, Amanda J, Tang, Justin I, Nyirenda, Moffat J

“…Compelling epidemiological evidence suggests that exposure to an adverse intrauterine environment, manifested by low-birth weight, is associated with…”
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Characteristics of salivary telomere length shortening in preterm infants by Schneper, Lisa M, Drake, Amanda J, Dunstan, Taylor, Kotenko, Iulia, Notterman, Daniel A, Piyasena, Chinthika

“…To examine the association between gestational age, telomere length (TL) and rate of shortening in newborns. Genomic DNA was isolated from buccal samples of 39…”
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Preterm Birth and the Risk of Neurodevelopmental Disorders - Is There a Role for Epigenetic Dysregulation? by Fitzgerald, Eamon, Boardman, James P, Drake, Amanda J

“…Preterm Birth (PTB) accounts for approximately 11% of all births worldwide each year and is a profound physiological stressor in early life. The burden of…”
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Non-alcoholic fatty liver disease (NAFLD) is associated with dynamic changes in DNA hydroxymethylation by Lyall, Marcus J., Thomson, John P., Cartier, Jessy, Ottaviano, Raffaele, Kendall, Timothy J., Meehan, Richard R., Drake, Amanda J.

“…Non-alcoholic fatty liver disease (NAFLD) is now the commonest cause of liver disease in developed countries affecting 25-33% of the general population and up…”
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Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats by Drake, Amanda J, Walker, Brian R, Seckl, Jonathan R

“…Epidemiological studies linking low birth weight and subsequent cardiometabolic disease have given rise to the hypothesis that events in fetal life permanently…”
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Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents by van den Driesche, Sander, Walker, Marion, McKinnell, Chris, Scott, Hayley M, Eddie, Sharon L, Mitchell, Rod T, Seckl, Jonathan R, Drake, Amanda J, Smith, Lee B, Anderson, Richard A, Sharpe, Richard M

“…Reproductive disorders that are common/increasing in prevalence in human males may arise because of deficient androgen production/action during a fetal…”
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Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations by Cartier, Jessy, Smith, Thomas, Thomson, John P, Rose, Catherine M, Khulan, Batbayar, Heger, Andreas, Meehan, Richard R, Drake, Amanda J

“…Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a…”
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Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland by Boardman, James P, Hall, Jill, Thrippleton, Michael J, Reynolds, Rebecca M, Bogaert, Debby, Davidson, Donald J, Schwarze, Jurgen, Drake, Amanda J, Chandran, Siddharthan, Bastin, Mark E, Fletcher-Watson, Sue

“…IntroductionPreterm birth is closely associated with altered brain development and is a leading cause of neurodevelopmental, cognitive and behavioural…”
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Maternal Obesity Has Little Effect on the Immediate Offspring but Impacts on the Next Generation by King, Vicky, Dakin, Rachel S, Liu, Lincoln, Hadoke, Patrick W. F, Walker, Brian R, Seckl, Jonathan R, Norman, Jane E, Drake, Amanda J

“…Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to…”
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Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat by van den Driesche, Sander, Kolovos, Petros, Platts, Sophie, Drake, Amanda J, Sharpe, Richard M

“…The testicular dysgenesis syndrome (TDS) hypothesis proposes that maldevelopment of the testis, irrespective of cause, leads to malfunction of the somatic…”
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Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences by Fitzgerald, Eamon, Hor, Kahyee, Drake, Amanda J.

“…An optimal early life environment is crucial for ensuring ideal neurodevelopmental outcomes. Brain development consists of a finely tuned series of spatially…”
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Relationship between Androgen Action in the “Male Programming Window,” Fetal Sertoli Cell Number, and Adult Testis Size in the Rat by Scott, Hayley M, Hutchison, Gary R, Jobling, Matthew S, McKinnell, Chris, Drake, Amanda J, Sharpe, Richard M

“…Fetal androgen action is an important determinant of Sertoli cell (SC) number at birth. Androgens “program” reproductive tract development in rats between…”
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