Search Results - "Dragojevic, Sonja"

Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery by Dragojevic, Sonja, Turner, Lindsay, Raucher, Drazen

“…Although doxorubicin (dox), an anthracycline antibiotic, is widely used and effective in treating cancer, its treatment efficiency is limited by low blood…”
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Polymer-Based Prodrugs: Improving Tumor Targeting and the Solubility of Small Molecule Drugs in Cancer Therapy by Dragojevic, Sonja, Ryu, Jung Su, Raucher, Drazen

“…The majority of anticancer drugs have poor aqueous solubility, produce adverse effects in healthy tissue, and thus impose major limitations on both clinical…”
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Macromolecular Drug Carriers for Targeted Glioblastoma Therapy: Preclinical Studies, Challenges, and Future Perspectives by Raucher, Drazen, Dragojevic, Sonja, Ryu, Jungsu

“…Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable cancers-owing to its strong tendency for intracranial dissemination, high…”
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Evaluation of Elastin-Like Polypeptides for Tumor Targeted Delivery of Doxorubicin to Glioblastoma by Dragojevic, Sonja, Mackey, Rebecca, Raucher, Drazen

“…To increase treatment efficiency for glioblastoma, we have developed a system to selectively deliver chemotherapeutic doxorubicin (Dox) to Glioblastoma (GBM)…”
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Targeted Drug Delivery Biopolymers Effectively Inhibit Breast Tumor Growth and Prevent Doxorubicin-Induced Cardiotoxicity by Dragojevic, Sonja, Ryu, Jung Su, Hall, Michael E, Raucher, Drazen

“…The anticancer agent doxorubicin(dox) has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite doxorubicin's…”
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Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma by Dragojevic, Sonja, Turner, Lindsay, Pal, Pallabi, Janorkar, Amol V, Raucher, Drazen

“…Glioblastoma (GBM) is a primary brain tumor that carries a dismal prognosis, which is primarily attributed to tumor recurrence after surgery and resistance to…”
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Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines by Thomas, Emily, Dragojevic, Sonja, Price, Amira, Raucher, Drazen

“…The application of rationally designed therapeutic peptides (TP) may improve outcomes in cancer treatment. These peptides hold the potential to directly target…”
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Abstract 3708: Targeted delivery of doxorubicin to glioblastomas by thermally sensitive polypeptides by Dragojevic, Sonja, Mackey, Rebecca B., Kratz, Felix, Raucher, Drazen

“…Abstract Glioblastoma (GBM) ranks among the most common, aggressive, and least curable cancers due to a strong tendency for intracranial dissemination, high…”
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Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases by Talele, Surabhi, Zhang, Wenjuan, Oh, Ju-Hee, Burgenske, Danielle M, Mladek, Ann C, Dragojevic, Sonja, Sarkaria, Jann N, Elmquist, William F

“…Cytotoxic effects of chemotherapy and radiation therapy (RT) used for the treatment of brain metastases results from DNA damage within cancer cells. Cells rely…”
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Abstract 3106: Targeted delivery via Elastin Like Polypeptide: Biodistribution of a doxorubicin derivative in MDA-MB231 human breast cancer xenografts in mice by Dragojevic, Sonja, Ryu, Jung Su, Kratz, Felix, Raucher, Drazen

“…Abstract The anticancer agent doxorubicin has been widely used in the treatment of a variety of hematological malignancies and solid tumors. Despite…”
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Abstract 2168: Optimizing doxorubicin derivatives delivery using temperature sensitive biopolymers in multidrug resistant breast cancer cells by Dragojevic, Sonja, Ryu, Jung Su, Kratz, Felix, Raucher, Drazen

“…Abstract The anticancer agent doxorubicin is an anthracycline compound that shows high potency in treating cancer, and it is one of the most widely used…”
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Brain Distribution of Berzosertib: An Ataxia Telangiectasia and Rad3-Related Protein Inhibitor for the Treatment of Glioblastoma by Talele, Surabhi, Zhang, Wenjuan, Burgenske, Danielle M, Kim, Minjee, Mohammad, Afroz S, Dragojevic, Sonja, Gupta, Shiv K, Bindra, Ranjit S, Sarkaria, Jann N, Elmquist, William F

“…The effective treatment of brain tumors is a considerable challenge in part because of the presence of the blood-brain barrier (BBB) that limits drug delivery…”
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Elastin-like Polypeptide for Targeted Delivery of Doxorubicin in the Treatment of Brain and Breast Cancers by Dragojevic, Sonja

“…Cancer represents a diverse group of diseases that can affect almost all organs and body systems. The traditional treatment for cancer is based on a multimodal…”
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Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts by Ji, Jianxiang, Dragojevic, Sonja, Callaghan, Cameron M, Smith, Emily J, Talele, Surabhi, Zhang, Wenjuan, Connors, Margaret A, Mladek, Ann C, Hu, Zeng, Bakken, Katrina K, Sarkaria, Paige P, Carlson, Brett L, Burgenske, Danielle M, Decker, Paul A, Rashid, Mohammad Abdur, Jang, Mi-Hyeon, Gupta, Shiv K, Eckel-Passow, Jeanette E, Elmquist, William F, Sarkaria, Jann N

“…Radioresistance of melanoma brain metastases limits the clinical utility of conventionally fractionated brain radiation in this disease, and strategies to…”
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Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers by Dragojevic, Sonja, Ji, Jianxiong, Singh, Pankaj K., Connors, Margaret A., Mutter, Robert W., Lester, Scott C., Talele, Surabhi M., Zhang, Wenjuan, Carlson, Brett L., Remmes, Nicholas B., Park, Sean S., Elmquist, William F., Krishnan, Sunil, Tryggestad, Erik J., Sarkaria, Jann N.

“…Genotoxic damage induced by radiation triggers a highly coordinated DNA damage response, and molecular inhibitors of key nodes within this complex response…”
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EXTH-01. INHIBITION OF DNA-PKcs BY M3814 POTENTIATES EFFICACY OF IONIZING RADIATION IN PATIENT-DERIVED XENOGRAFTS OF MELANOMA BRAIN METASTASES by Ji, Jianxiong, Smith, Emily, Sarkaria, Paige, Mladek, Ann, Talele, Surabhi, Swanson, Katelyn, Mohammad, Afroz S, Zhang, Wenjuan, He, Lihong, Hu, Zeng, Zhao, Yu, Chen, Jiajia, Connors, Margaret A, Porath, Kendra A, Bakken, Katrina K, Dragojevic, Sonja, Carlson, Brett L, Gupta, Shiv K, Burgenske, Danielle M, Kitange, Gaspar J, Elmquist, William F, Sarkaria, Jann

“…Abstract Radio-resistance mechanisms limit the benefit of radiation therapy (RT) for melanoma brain metastases. A key pathway for radiation-induced DNA…”
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Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts by Porath, Kendra A, Regan, Michael S, Griffith, Jessica I, Jain, Sonia, Stopka, Sylwia A, Burgenske, Danielle M, Bakken, Katrina K, Carlson, Brett L, Decker, Paul A, Vaubel, Rachael A, Dragojevic, Sonja, Mladek, Ann C, Connors, Margaret A, Hu, Zeng, He, Lihong, Kitange, Gaspar J, Gupta, Shiv K, Feldsien, Thomas M, Lefebvre, Didier R, Agar, Nathalie Y R, Eckel-Passow, Jeanette E, Reilly, Edward B, Elmquist, William F, Sarkaria, Jann N

“…EGFR targeting antibody-drug conjugates (ADCs) are highly effective against EGFR-amplified tumors, but poor distribution across the blood-brain barrier (BBB)…”
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