Search Results - "Dragnev, K."

Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial by Weiss, J.M., Csoszi, T., Maglakelidze, M., Hoyer, R.J., Beck, J.T., Domine Gomez, M., Lowczak, A., Aljumaily, R., Rocha Lima, C.M., Boccia, R.V., Hanna, W., Nikolinakos, P., Chiu, V.K., Owonikoko, T.K., Schuster, S.R., Hussein, M.A., Richards, D.A., Sawrycki, P., Bulat, I., Hamm, J.T., Hart, L.L., Adler, S., Antal, J.M., Lai, A.Y., Sorrentino, J.A., Yang, Z., Malik, R.K., Morris, S.R., Roberts, P.J., Dragnev, K.H.

“…Chemotherapy-induced damage of hematopoietic stem and progenitor cells (HSPC) causes multi-lineage myelosuppression. Trilaciclib is an intravenous CDK4/6…”
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Trilaciclib (trila) preserves and enhances immune system function in extensive-stage small cell lung cancer (ES-SCLC) patients receiving first-line chemotherapy by Sorrentino, J.A., Lai, A., Weiss, J.M., Dragnev, K.H., Owonikoko, T.K., Adler, S., Antal, J.M., Malik, R.K., Roberts, P.J.

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Trilaciclib (T) decreases multi-lineage myelosuppression in extensive-stage small cell lung cancer (ES-SCLC) patients receiving first-line chemotherapy by Dragnev, K.H., Owonikoko, T.K., Csoszi, T., Maglakelidze, M., Beck, J.T., Domine Gomez, M., Lowczak, A., Fulop, A., Hoyer, R.J., Hanna, W., Lowry, P., Aljumaily, R., Chiu, V.K., Bulat, I., Yang, Z., Roberts, P.J., Antal, J.M., Malik, R.K., Morris, S.R., Weiss, J.M.

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A UV-visible-NIR fluorescence lifetime imaging microscope for laser-based biological sensing with picosecond resolution by URAYAMA, P, ZHONG, W, BEAMISH, J. A, MINN, F. K, SLOBODA, R. D, DRAGNEV, K. H, DMITROVSKY, E, MYCEK, M.-A

“…This article describes the design and characterization of a wide-field, time-domain fluorescence lifetime imaging microscopy (FLIM) system developed for…”
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Focal paraneoplastic limbic encephalitis presenting as orgasmic epilepsy by FADUL, C. E, STOMMEL, E. W, DRAGNEV, K. H, ESKEY, C. J, DALMAU, J. O

“…To report orgasmic epilepsy as a manifestation of paraneoplastic limbic encephalitis in a patient with small cell lung cancer. A 57 years-old woman presented…”
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Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol by Grubbs, C J, Steele, V E, Casebolt, T, Juliana, M M, Eto, I, Whitaker, L M, Dragnev, K H, Kelloff, G J, Lubet, R L

“…Indole-3-carbinol, a component of cruciferous vegetables, was evaluated for it efficacy in the prevention of chemically-induced mammary tumors using three…”
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The Retinoids and Cancer Prevention Mechanisms by Dragnev, Konstantin H., Rigas, James R., Dmitrovsky, Ethan

“…Carcinogenesis is a multistep process that converts normal cells into malignant cells. Once transformed, malignant cells acquire the ability to invade and…”
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The future beyond platinum for the treatment of advanced non-small cell lung cancer by Dragnev, K H, Rigas, J R

“…The development of chemotherapy for advanced non-small cell lung cancer has been most productive in its fifth decade. We began this decade by establishing…”
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1047P Lung-MAP S1800A: Exploratory analysis of prior immunotherapy outcomes on OS with ramucirumab plus pembrolizumab for NSCLC with PD on prior ICI by Reckamp, K., Redman, M.W., Dragnev, K., Villaruz, L., Faller, B., Al Baghdadi, T., Hines, S., Minichiello, K., Gandara, D.R., Kelly, K., Herbst, R.S.

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Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells by Pitts, J D, Sloboda, R D, Dragnev, K H, Dmitrovsky, E, Mycek, M A

“…Tissue autofluorescence has been explored as a potential method of noninvasive pre-neoplasia (pre-malignancy) detection in the lung. Here, we report the first…”
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Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function by CURTIN, Joshua C, DRAGNEV, Konstantin H, SEKULA, David, CHRISTIE, Allison J, DMITROVSKY, Ethan, SPINELLA, Michael J

“…Although retinoids are known to regulate gene transcription by activating retinoid receptors, the targets of retinoid receptors are largely unknown. This study…”
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The chemopreventive agent diallyl sulfide: A structurally atypical phenobarbital-type inducer by Dragnev, Konstantin H., Nims, Raymond W., Lubet, Ronald A.

“…Diallyl sulfide (DAS), a known chemopreventive agent, was administered i.g. (200 or 500 mg/kg body wt/day) to male F344/NCr rats for 4 days. Livers were…”
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In Vivo Induction and in Vitro Inhibition of Hepatic Cytochrome P450 Activity by the Benzodiazepine Anticonvulsants Clonazepam and Diazepam by NIMS, R. W, PROUGH, R. A, JONES, C. R, STOCKUS, D. L, DRAGNEV, K. H, THOMAS, P. E, LUBET, R. A

“…The ability of the benzodiazepines, as a chemical class, to cause the induction and/or inhibition of cytochromes P450 has not been well characterized. In the…”
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A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat. Effects of chemicals of varied structure by Lubet, R A, Dragnev, K H, Chauhan, D P, Nims, R W, Diwan, B A, Ward, J M, Jones, C R, Rice, J M, Miller, M S

“…The effects of a number of phenobarbital-type inducers on selected drug-metabolizing enzymes in male F344/NCr rats were determined by measuring specific…”
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1671PTrilaciclib (trila) preserves and enhances immune system function in extensive-stage small cell lung cancer (ES-SCLC) patients receiving first-line chemotherapy by Sorrentino, J A, Lai, A, Weiss, J M, Dragnev, K H, Owonikoko, T K, Adler, S, Antal, J M, Malik, R K, Roberts, P J

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Regulation of gene expression of various Phase I and Phase II drug-metabolizing enzymes by tamoxifen in rat liver by Hellriegel, Edward T., Matwyshyn, George A., Fei, Peiwen, Dragnev, Konstantin H., Nims, Raymond W., Lubet, Ronald A., Kong, Ah-Ng Tony

“…The objective of the present investigation was to evaluate the effect of tamoxifen (TAM) on the gene expression of different phase I and phase II…”
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Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors by WEGHORST, C. M, DRAGNEV, K. H, BUZARD, G. S, THORNE, K. L, VANDEBORNE, G. F, VINCENT, K. A, RICE, J. M

“…Previous studies have shown renal mesenchymal tumors (RMTs) induced in rats by a single intrarenal injection of nickel subsulfide and iron are more pleomorphic…”
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Thymoma associated with syndrome of inappropriate antidiuretic hormone secretion and myasthenia gravis by DONADIO, A. C, DRAGNEV, K. H, SCHWARTZ, G

“…We describe the association of malignant thymoma with the syndrome of inappropriate antidiuretic hormone secretion and myasthenia gravis. Hyponatremia has not…”
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Effect of Tumor Volume Doubling Time on Prognosis for Stage I Non–small Cell Lung Cancers by No, H., Gagne, H.M., Nelson, C.J., Kinsey, M., Garrison, G., Kikut, J., Gentchos, G., Seward, D., Sidiropoulos, N., Folefac, E., Leavitt, B., Ashikaga, T., Dragnev, K., Lin, S.H., Anker, C.J.

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1666PDTrilaciclib (T) decreases multi-lineage myelosuppression in extensive-stage small cell lung cancer (ES-SCLC) patients receiving first-line chemotherapy by Dragnev, K H, Owonikoko, T K, Csoszi, T, Maglakelidze, M, Beck, J T, Domine Gomez, M, Lowczak, A, Fulop, A, Hoyer, R J, Hanna, W, Lowry, P, Aljumaily, R, Chiu, V K, Bulat, I, Yang, Z, Roberts, P J, Antal, J M, Malik, R K, Morris, S R, Weiss, J M

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