Search Results - "Dragani, Tommaso"

Risk of HCC: Genetic heterogeneity and complex genetics by Dragani, Tommaso A

“…Hepatocellular carcinoma (HCC) is a common form of cancer that arises from hepatocytes and whose risk may be affected by several known environmental factors,…”
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COVID-19 mortality in Italy varies by patient age, sex and pandemic wave by Minnai, Francesca, De Bellis, Gianluca, Dragani, Tommaso A., Colombo, Francesca

“…SARS-CoV-2 has caused a worldwide epidemic of enormous proportions, which resulted in different mortality rates in different countries for unknown reasons. We…”
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Biomarkers for Early Cancer Diagnosis: Prospects for Success through the Lens of Tumor Genetics by Dragani, Tommaso A., Matarese, Valerie, Colombo, Francesca

“…Thousands of candidate cancer biomarkers have been proposed, but so far, few are used in cancer screening. Failure to implement these biomarkers is attributed…”
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The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science by Spyrakis, Francesca, Dragani, Tommaso A.

“…The proposal by the European Chemicals Agency (ECHA) to ban over 12,000 per- and polyfluoroalkyl substances (PFAS) has sparked a debate about potential…”
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Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants by Cotroneo, Chiara E, Mangano, Nunzia, Dragani, Tommaso A, Colombo, Francesca

“…Germline variants in genes involved in SARS-CoV-2 cell entry and in host innate immune responses to viruses may influence the susceptibility to infection. This…”
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Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure by Dragani, Tommaso A, Colombo, Francesca, Pavlisko, Elizabeth N, Roggli, Victor L

“…In malignant mesothelioma patients, we found that diagnosis occurred at a younger age in subjects with high levels of asbestos bodies and fibers in lung…”
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Gut microbiota composition in colorectal cancer patients is genetically regulated by Colombo, Francesca, Illescas, Oscar, Noci, Sara, Minnai, Francesca, Pintarelli, Giulia, Pettinicchio, Angela, Vannelli, Alberto, Sorrentino, Luca, Battaglia, Luigi, Cosimelli, Maurizio, Dragani, Tommaso A., Gariboldi, Manuela

“…The risk of colorectal cancer (CRC) depends on environmental and genetic factors. Among environmental factors, an imbalance in the gut microbiota can increase…”
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Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue by Minnai, Francesca, Noci, Sara, Chierici, Marco, Cotroneo, Chiara Elisabetta, Bartolini, Barbara, Incarbone, Matteo, Tosi, Davide, Mattioni, Giovanni, Jurman, Giuseppe, Dragani, Tommaso A., Colombo, Francesca

“…Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral…”
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Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer by Galvan, Antonella, Ioannidis, John P.A, Dragani, Tommaso A

“…Genome-wide association studies (GWAS) using population-based designs have identified many genetic loci associated with risk of a range of complex diseases…”
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Effect of neoadjuvant chemoradiation on anorectal function assessed with anorectal manometry: A systematic review and meta-analysis by Milito, Pamela, Piozzi, Guglielmo Niccolò, Hussain, Mohammad Iqbal, Dragani, Tommaso A., Sorrentino, Luca, Cosimelli, Maurizio, Guaglio, Marcello, Battaglia, Luigi

“…Aim: Improvement in oncological survival for rectal cancer increases attention to anorectal dysfunction. Diagnostic questionnaires can evaluate quality of life…”
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Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients by Pintarelli, Giulia, Noci, Sara, Maspero, Davide, Pettinicchio, Angela, Dugo, Matteo, De Cecco, Loris, Incarbone, Matteo, Tosi, Davide, Santambrogio, Luigi, Dragani, Tommaso A., Colombo, Francesca

“…Alterations in the gene expression of organs in contact with the environment may signal exposure to toxins. To identify genes in lung tissue whose expression…”
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Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes by Maspero, Davide, Dassano, Alice, Pintarelli, Giulia, Noci, Sara, De Cecco, Loris, Incarbone, Matteo, Tosi, Davide, Santambrogio, Luigi, Dragani, Tommaso A, Colombo, Francesca

“…Abstract Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic…”
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Response to comments on 'Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure' by Farioli et al. and Oddone et al by Dragani, Tommaso A, Colombo, Francesca, Pavlisko, Elizabeth N, Roggli, Victor L

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Human Lung Tissue Transcriptome: Influence of Sex and Age by Dugo, Matteo, Cotroneo, Chiara E, Lavoie-Charland, Emilie, Incarbone, Matteo, Santambrogio, Luigi, Rosso, Lorenzo, van den Berge, Maarten, Nickle, David, Paré, Peter D, Bossé, Yohan, Dragani, Tommaso A, Colombo, Francesca

“…Sex and age strongly influence the pathophysiology of human lungs, but scarce information is available about their effects on pulmonary gene expression. We…”
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Neuraxial anesthesia for abdominal surgery, beyond the pandemic: a feasibility pilot study of 70 patients in a suburban hospital by Romanzi, Andrea, Dragani, Tommaso A., Adorni, Adele, Colombo, Martina, Farro, Antonio, Maspero, Mosè, Zamburlini, Beatrice, Vannelli, Alberto

“…The aim of this study is to establish the feasibility of awake laparotomy under neuraxial anesthesia (NA) in a suburban hospital. A retrospective analysis of…”
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Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci by Manenti, Giacomo, Galvan, Antonella, Pettinicchio, Angela, Trincucci, Gaia, Spada, Elena, Zolin, Anna, Milani, Silvano, Gonzalez-Neira, Anna, Dragani, Tommaso A

“…We carried out genome-wide association (GWA) studies in inbred mouse strains characterized for their lung tumor susceptibility phenotypes (spontaneous or…”
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Unique microRNA‐profiles in EGFR‐mutated lung adenocarcinomas by Bjaanæs, Maria Moksnes, Halvorsen, Ann Rita, Solberg, Steinar, Jørgensen, Lars, Dragani, Tommaso A., Galvan, Antonella, Colombo, Francesca, Anderlini, Marco, Pastorino, Ugo, Kure, Elin, Børresen‐Dale, Anne‐Lise, Brustugun, Odd Terje, Helland, Åslaug

“…The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to…”
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Oligogenic germline mutations identified in early non-smokers lung adenocarcinoma patients by Renieri, Alessandra, Mencarelli, Maria Antonietta, Cetta, Francesco, Baldassarri, Margherita, Mari, Francesca, Furini, Simone, Piu, Pietro, Ariani, Francesca, Dragani, Tommaso A, Frullanti, Elisa

“…Abstract Objectives A polygenic model is commonly assumed for the predisposition to common cancers. With respect to lung cancer, Genome Wide Association…”
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Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated with Advanced Stage, Female Sex, and Ever-Smoker Status, in Patients Treated with Lung Resection by Dragani, Tommaso A, Muley, Thomas, Schneider, Marc A, Kobinger, Sonja, Eichhorn, Martin, Winter, Hauke, Hoffmann, Hans, Kriegsmann, Mark, Noci, Sara, Incarbone, Matteo, Tosi, Davide, Franzi, Sara, Colombo, Francesca

“…To date, the factors which affect the age at diagnosis of lung adenocarcinoma are not fully understood. In our study, we examined the relationships of age at…”
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Testing of human papillomavirus in lung cancer and non-tumor lung tissue by Galvan, Antonella, Noci, Sara, Taverna, Francesca, Lombardo, Claudia, Franceschi, Silvia, Pastorino, Ugo, Dragani, Tommaso A

“…Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of…”
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