Investigation on the biodurability of chemically different stone wool fibres

The biodurability is one of the essential factors for a carcinogenic potential of mineral fibres. The in vivo solubility of commercial fibre products can be influenced by modifications of the chemical composition. Two types of experimental stone wool samples with new chemical composition were compar...

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Bibliographic Details
Published in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 47; no. 2; pp. 195 - 201
Main Authors:	Bellmann, B., Muhle, H., Kamstrup, O., Draeger, U.F.
Format:	Journal Article
Language:	English
Published:	Jena Elsevier GmbH 01-05-1995 Elsevier
Subjects:	Animals Biodurability, stone wool fibres Biological and medical sciences Ceramics - adverse effects Ceramics - chemistry Chemical and industrial products toxicology. Toxic occupational diseases Clearance, lung Female Fibres, stone wool Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Intubation, Intratracheal Lung - chemistry Lung - metabolism Lung clearance Lung, stone wool fibres Medical sciences Mineral Fibers - adverse effects Mineral Fibers - analysis Mucociliary Clearance Rats Rats, Wistar Stone wool fibres Toxicology Lung clearance Biodurability, stone wool fibres Lung, stone wool fibres Clearance, lung Fibres, stone wool Stone wool fibres Lung disease Pneumoconiosis Rat Respiratory disease Lung Rodentia Fiber Clearance Persistence Vertebrata Experimental disease Mammalia Animal
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Summary:	The biodurability is one of the essential factors for a carcinogenic potential of mineral fibres. The in vivo solubility of commercial fibre products can be influenced by modifications of the chemical composition. Two types of experimental stone wool samples with new chemical composition were compared to a commercial stone wool sample. Sized fractions of these samples with median lengths of 7.1, 9.3 and 6.7 μm, respectively, and median diameters of 0.76, 1.02 and 0.63 μm, respectively, were intratracheally instilled into female Wistar rats with a single dose of 2 mg in 0.3 ml. 5 animals per group were sacrificed after 2 days, 1, 3, 6, 12 and 18 months. After low-temperature ashing of the lungs about 1000 fibres per group and sacrifice date were analysed in SEM for length and diameter. The number of fibres in the total lung was calculated. An analysis of fibre number of different length and diameter fractions was used to estimate whether dissolution, breakage or mechanical clearance is responsible for the elimination of fibres from the lung. Results indicate that the breakage of fibres with length above 20 μm and the dissolution of fibres was faster in the experimental stone wool samples compared to the commercial sample.
ISSN:	0940-2993 1618-1433
DOI:	10.1016/S0940-2993(11)80314-3