Search Results - "Drader, Jared J"

Rapid identification of emerging pathogens: coronavirus by Sampath, Rangarajan, Hofstadler, Steven A, Blyn, Lawrence B, Eshoo, Mark W, Hall, Thomas A, Massire, Christian, Levene, Harold M, Hannis, James C, Harrell, Patina M, Neuman, Benjamin, Buchmeier, Michael J, Jiang, Yun, Ranken, Raymond, Drader, Jared J, Samant, Vivek, Griffey, Richard H, McNeil, John A, Crooke, Stanley T, Ecker, David J

“…We describe a new approach for infectious disease surveillance that facilitates rapid identification of known and emerging pathogens. The process uses…”
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Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry by Park, Hae-Min, Winton, Valerie J, Drader, Jared J, Manalili Wheeler, Sheri, Lazar, Greg A, Kelleher, Neil L, Liu, Yichin, Tran, John C, Compton, Philip D

“…With the rapid rise of therapeutic antibodies and antibody-drug conjugates, significant investments have been made in developing workflows that utilize mass…”
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Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis by Van Ert, Matthew N, Hofstadler, Steven A, Jiang, Yun, Busch, Joseph D, Wagner, David M, Drader, Jared J, Ecker, David J, Hannis, James C, Huynh, Lynn Y, Schupp, James M, Simonson, Tatum S, Keim, Paul

“…Epidemiological and forensic analyses of bioterrorism events involving Bacillus anthracis could be improved if both variable number tandem repeats (VNTRs) and…”
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Characterization of Low-Affinity Complexes between RNA and Small Molecules Using Electrospray Ionization Mass Spectrometry by Griffey, Richard H, Sannes-Lowery, Kristin A, Drader, Jared J, Mohan, Venkatraman, Swayze, Eric E, Hofstadler, Steven A

“…Electrospray ionization mass spectrometry (ESI-MS) provides a sensitive method for the characterization of low-affinity (∼mM) complexes between nucleic acids…”
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Multitarget Affinity/Specificity Screening of Natural Products:  Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry by Cummins, Lendell L., Chen, Shuo, Blyn, Larry B., Sannes-Lowery, Kristin A., Drader, Jared J., Griffey, Richard H., Hofstadler, Steven A.

“…In this work we describe a high-throughput screening approach based on electrospray ionization−Fourier transform ion cyclotron resonance mass spectrometry…”
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Human RNase H1 Activity Is Regulated by a Unique Redox Switch Formed between Adjacent Cysteines by Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Manalili, Sherilynn M., Drader, Jared J., Hofstadler, Steven A., Crooke, Stanley T.

“…Human RNase H1 is active only under reduced conditions. Oxidation as well as N-ethylmaleimide (NEM) treatment of human RNase H1 ablates the cleavage activity…”
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Usefulness of multilocus polymerase chain reaction followed by electrospray ionization mass spectrometry to identify a diverse panel of bacterial isolates by Baldwin, Carson D, Howe, Gerald B, Sampath, Ranga, Blyn, Larry B, Matthews, Heather, Harpin, Vanessa, Hall, Thomas A, Drader, Jared J, Hofstadler, Steve A, Eshoo, Mark W, Rudnick, Karl, Studarus, Karen, Moore, David, Abbott, Sharon, Janda, J. Michael, Whitehouse, Chris A

“…Abstract Polymerase chain reaction electrospray ionization mass spectrometry (PCR/ESI-MS) was tested for its ability to accurately identify a blinded panel of…”
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Base composition analysis of human mitochondrial DNA using electrospray ionization mass spectrometry: A novel tool for the identification and differentiation of humans by Hall, Thomas A., Budowle, Bruce, Jiang, Yun, Blyn, Lawrence, Eshoo, Mark, Sannes-Lowery, Kristin A., Sampath, Rangarajan, Drader, Jared J., Hannis, James C., Harrell, Patina, Samant, Vivek, White, Neill, Ecker, David J., Hofstadler, Steven A.

“…In traditional approaches, mitochondrial DNA (mtDNA) variation is exploited for forensic identity testing by sequencing the two hypervariable regions of the…”
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Selective Ion Filtering by Digital Thresholding:  A Method To Unwind Complex ESI-Mass Spectra and Eliminate Signals from Low Molecular Weight Chemical Noise by Hofstadler, Steven A, Drader, Jared J, Schink, Amy

“…In this work, we present a simple method by which to preferentially detect either high molecular weight or low molecular weight ions generated by electrospray…”
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Infrared Multiphoton Dissociation with a Hollow Fiber Waveguide by Drader, Jared J, Hannis, James C, Hofstadler, Steven A

“…A novel scheme for performing infrared multiphoton dissociation (IRMPD) is presented in which a hollow fiber waveguide (HFWG) is used to transmit IR radiation…”
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Fourier transform ion cyclotron resonance mass spectrometry as a high throughput affinity screen to identify RNA binding ligands by Sannes-Lowery, Kristin A, Drader, Jared J, Griffey, Richard H, Hofstadler, Steven A

“…The continuing evolution of analytical instrumentation based on high performance mass spectrometry has catalyzed the development of more sophisticated and…”
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Alternative approaches to infrared multiphoton dissociation in an external ion reservoir by Hofstadler, Steven A, Drader, Jared J, Gaus, Hans, Hannis, James C, Sannes-Lowery, Kristin A

“…In this work we present variations on in-hexapole infrared multiphoton dissociation (IRMPD) for the characterization of modified oligonucleotides using an…”
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Digital Quadrature Heterodyne Detection for High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Drader, Jared J, Shi, Stone D.-H, Blakney, Greg T, Hendrickson, Christopher L, Laude, David A, Marshall, Alan G

“…The pursuit of ever higher mass-resolving power in Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has driven a demand for higher…”
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Fourier transform ion cyclotron resonance mass spectrometry in a high homogeneity 25 tesla resistive magnet by Shi, Stone D.-H, Drader, Jared J, Hendrickson, Christopher L, Marshall, Alan G

“…Many performance parameters of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry improve dramatically with increasing magnetic field. Our…”
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Real-Time Monitoring of the Gas Phase Reactions of a Single Ion Population Using the Remeasurement Experiment in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Guan, Ziqiang, Drader, Jared J, Campbell, Victoria L, Laude, David A

“…A single population of multiply charged protein ions formed by electrospray ionization is held in a trapped ion cell and remeasured continuously by Fourier…”
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Rapid Identification and Strain-Typing of Respiratory Pathogens for Epidemic Surveillance by Ecker, David J., Sampath, Rangarajan, Blyn, Lawrence B., Eshoo, Mark W., Ivy, Cristina, Ecker, Joseph A., Libby, Brian, Samant, Vivek, Sannes-Lowery, Kristin A., Melton, Rachael E., Russell, Kevin, Freed, Nikki, Barrozo, Chris, Wu, Jianguo, Rudnick, Karl, Desai, Anjali, Moradi, Emily, Knize, Duane J., Robbins, David W., Hannis, James C., Harrell, Patina M., Massire, Christian, Hall, Thomas A., Jiang, Yun, Ranken, Raymond, Drader, Jared J., White, Neill, McNeil, John A., Crooke, Stanley T., Hofstadler, Steven A., Falkow, Stanley

“…Epidemic respiratory infections are responsible for extensive morbidity and mortality within both military and civilian populations. We describe a…”
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TIGER: the universal biosensor by Hofstadler, Steven A., Sampath, Rangarajan, Blyn, Lawrence B., Eshoo, Mark W., Hall, Thomas A., Jiang, Yun, Drader, Jared J., Hannis, James C., Sannes-Lowery, Kristin A., Cummins, Lendell L., Libby, Brian, Walcott, Demetrius J., Schink, Amy, Massire, Christian, Ranken, Raymond, Gutierrez, Jose, Manalili, Sheri, Ivy, Cristina, Melton, Rachael, Levene, Harold, Barrett-Wilt, Greg, Li, Feng, Zapp, Vanessa, White, Neill, Samant, Vivek, McNeil, John A., Knize, Duane, Robbins, David, Rudnick, Karl, Desai, Anjali, Moradi, Emily, Ecker, David J.

“…In this work, we describe a strategy for the detection and characterization of microorganisms associated with a potential biological warfare attack or a…”
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Comparison and interconversion of the two most common frequency-to-mass calibration functions for Fourier transform ion cyclotron resonance mass spectrometry by Shi, Stone D.-H., Drader, Jared J., Freitas, Michael A., Hendrickson, Christopher L., Marshall, Alan G.

“…In a perfect three-dimensional axial quadrupolar electrostatic potential field, Ledford et al. showed that the frequency-to-mass calibration relation m/z = A L…”
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High throughput drug discovery with ESI-FTICR by Sannes-Lowery, Kristin A., Cummins, Lendell L., Chen, Shuo, Drader, Jared J., Hofstadler, Steven A.

“…Ribonucleic acids (RNA) are an attractive target for drug discovery since they play critical roles in cellular functions. Because small structured subdomains…”
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Iron-mediated Cycloaddition Reactions for Fe(1,3-Butadiene)2L+ (L=Ethyne, Propyne) Complexes in the Gas Phase. Butadiene/Butadiene Versus Butadiene/Alkyne Cycloaddition by Bakhtiar, Ray, Drader, Jared J., Arneson, Robin K., Jacobson, Denley B.

“…Competitive iron‐mediated cycloaddition of butadiene with butadiene versus cycloaddition of butadiene with alkynes in Fe(C4H6) + 2L (L = C 2H 2, C 3H 4)…”
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