Search Results - "Drabovich, Andrei P"

Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974[S] by Schiza, Christina, Korbakis, Dimitrios, Jarvi, Keith, Diamandis, Eleftherios P., Drabovich, Andrei P.

“…TEX101 protein is a validated biomarker of male infertility and a potential germ cell-surface chaperone. Near-complete degradation of variant G99V TEX101…”
Get full text

Verification of Male Infertility Biomarkers in Seminal Plasma by Multiplex Selected Reaction Monitoring Assay by Drabovich, Andrei P., Jarvi, Keith, Diamandis, Eleftherios P.

“…Seminal plasma is a promising biological fluid to use for noninvasive clinical diagnostics of male reproductive system disorders. To verify a list of…”
Get full text

Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies by Schiza, Christina, Korbakis, Dimitrios, Panteleli, Efstratia, Jarvi, Keith, Drabovich, Andrei P., Diamandis, Eleftherios P.

“…The interactome of human TEX101 protein in testicular tissues and spermatozoa was identified by applying a quantitative co-immunoprecipitation-MS approach…”
Get full text

Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility by Korbakis, Dimitrios, Schiza, Christina, Brinc, Davor, Soosaipillai, Antoninus, Karakosta, Theano D, Légaré, Christine, Sullivan, Robert, Mullen, Brendan, Jarvi, Keith, Diamandis, Eleftherios P, Drabovich, Andrei P

“…TEX101 is a cell membrane protein exclusively expressed by testicular germ cells and shed into seminal plasma. We previously verified human TEX101 as a…”
Get full text

Quantitative Analysis of Energy Metabolic Pathways in MCF-7 Breast Cancer Cells by Selected Reaction Monitoring Assay by Drabovich, Andrei P., Pavlou, Maria P., Dimitromanolakis, Apostolos, Diamandis, Eleftherios P.

“…To investigate the quantitative response of energy metabolic pathways in human MCF-7 breast cancer cells to hypoxia, glucose deprivation, and estradiol…”
Get full text

Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells by Drabovich, Andrei P., Pavlou, Maria P., Schiza, Christina, Diamandis, Eleftherios P.

“…Estrogen receptor alpha (ERα)-mediated proliferation of breast cancer cells is facilitated through expression of multiple primary target genes, products of…”
Get full text

Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas by Begcevic, Ilijana, Brinc, Davor, Drabovich, Andrei P, Batruch, Ihor, Diamandis, Eleftherios P

“…Cerebrospinal fluid (CSF) is a proximal fluid which communicates closely with brain tissue, contains numerous brain-derived proteins and thus represents a…”
Get full text

Combinatorial Peptide Libraries Facilitate Development of Multiple Reaction Monitoring Assays for Low-Abundance Proteins by Drabovich, Andrei P, Diamandis, Eleftherios P

“…Low-abundance proteins present in biological fluids are often considered an attractive source of new disease biomarkers. Since such proteins are poorly…”
Get full text

Selection of Smart Aptamers by Methods of Kinetic Capillary Electrophoresis by Drabovich, Andrei P., Berezovski, Maxim, Okhonin, Victor, Krylov, Sergey N.

“…We coin the term “smart aptamers”aptamers with predefined binding parameters (k on, k off, K d) of aptamer−target interaction. Aptamers, in general, are…”
Get full text

Assessment of Peptide Chemical Modifications on the Development of an Accurate and Precise Multiplex Selected Reaction Monitoring Assay for Apolipoprotein E Isoforms by Martínez-Morillo, Eduardo, Nielsen, Henrietta M, Batruch, Ihor, Drabovich, Andrei P, Begcevic, Ilijana, Lopez, Mary F, Minthon, Lennart, Bu, Guojun, Mattsson, Niklas, Portelius, Erik, Hansson, Oskar, Diamandis, Eleftherios P

“…Apolipoprotein E (ApoE) is a polymorphic protein that plays a major role in lipid metabolism in the central nervous system and periphery. It has three common…”
Get full text

Seminal biomarkers for the evaluation of male infertility by Bieniek, Jared, Drabovich, Andrei, Lo, Kirk

“…For men struggling to conceive with their partners, diagnostic tools are limited and often consist of only a standard semen analysis. This baseline test serves…”
Get full text

Non-SELEX: selection of aptamers without intermediate amplification of candidate oligonucleotides by Krylov, Sergey N, Berezovski, Maxim V, Musheev, Michael U, Drabovich, Andrei P, Jitkova, Julia V

“…Aptamers are typically selected from libraries of random DNA (or RNA) sequences through systematic evolution of ligands by exponential enrichment (SELEX),…”
Get full text

Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides by Dara, Delaram, Drabovich, Andrei P.

“…Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines,…”
Get full text

Identification and Quantification of Human Relaxin Proteins by Immunoaffinity-Mass Spectrometry by Rais, Yasmine, Drabovich, Andrei P.

“…The human relaxins belong to the Insulin/IGF/Relaxin superfamily of peptide hormones, and their physiological function is primarily associated with…”
Get full text

Rational Design and Development of SARS-CoV‑2 Serological Diagnostics by Immunoprecipitation-Targeted Proteomics by Fu, Zhiqiang, Rais, Yasmine, Dara, Delaram, Jackson, Dana, Drabovich, Andrei P.

“…Current design of serological tests utilizes conservative immunoassay approaches and is focused on fast and convenient assay development, throughput,…”
Get full text

Seminal plasma as a diagnostic fluid for male reproductive system disorders by Drabovich, Andrei P., Saraon, Punit, Jarvi, Keith, Diamandis, Eleftherios P.

“…Key Points Seminal plasma contains a large number of tissue-specific proteins secreted by individual organs of the male reproductive system Male reproductive…”
Get full text

Redefining serological diagnostics with immunoaffinity proteomics by Walter, Jonathan, Eludin, Zicki, Drabovich, Andrei P

“…Serological diagnostics is generally defined as the detection of specific human immunoglobulins developed against viral, bacterial, or parasitic diseases…”
Get full text

Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma by Drabovich, Andrei P, Dimitromanolakis, Apostolos, Saraon, Punit, Soosaipillai, Antoninus, Batruch, Ihor, Mullen, Brendan, Jarvi, Keith, Diamandis, Eleftherios P

“…Male fertility problems range from diminished production of sperm, or oligozoospermia, to nonmeasurable levels of sperm in semen, or azoospermia, which is…”
Get more information

Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants by Rais, Yasmine, Fu, Zhiqiang, Drabovich, Andrei P

“…Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on the measurements of viral RNA by RT-PCR, or detection of anti-viral…”
Get full text

Gasoline-derived methyl tert-butyl ether as a potential obesogen linked to metabolic syndrome by Rais, Yasmine, Drabovich, Andrei P.

Get full text